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Children with developmental dyslexia (DD) display partially preserved morphology skills which they rely upon for reading and spelling. Therefore, we conducted explicit and intensive training of derivational morphology in French and Swiss individuals with DD, ages 9 to 14 years, in order to assess its effect on: morphological awareness, reading (speed and accuracy), and spelling. Our pre-posttest design included a group trained in derivational morphology and a group of children who continued their business-as-usual rehabilitation program with their speech-language therapist. Results showed effects on morphological awareness and on the spelling of complex words, with a large between-group effect size for trained items and a large to moderate effect size for untrained items. All these gains tended to be maintained over time on the delayed posttest, 2 months later. For reading, the results were more contrasted, with large between-group effect sizes for accuracy and speed for trained items, reducing to a small effect for accuracy on the delayed posttest. For untrained items, small effects were observed on accuracy (at both posttests) but not on speed. These results are very promising and argue in favor of using derivational morphology as a medium to improve literacy skills in French-speaking children and adolescents with DD.

Morphological awareness has been shown to contribute to the acquisition of literacy in various languages. The current study focuses on an explicit derivational morphology training program in French-speaking fourth graders with the aim of measuring direct effects on morphological awareness and transfer effects on spelling and reading. The intensive training given in class consisted of (1) learning how to segment words into smaller units and (2) understanding the meaning of affixes in relation to words. Thirty-six children received the morphology training and 34 age-matched participants followed an alternative visuo-semantic training matched for intensity. The results of this pre-post group comparison study show a significant Group by Time interaction: Substantial progress in morphological awareness is observed for the group trained in morphology, on both trained as well as on untrained items. A similar gain was observed for the spelling of morphologically derived words, for trained and untrained words. Both roots and affixes were spelled more accurately. For reading however, we found a learning effect in speed and accuracy on trained words, but no generalization to untrained words. All effects were maintained four months after training. These results highlight the role that morphology plays in children's literacy development.

Purpose: Typically developing (TD) bilingual children usually produce narratives with preserved macrostructure (i.e., narrative scheme) but with impaired microstructure (i.e., language complexity). As for monolingual and bilingual children with developmental language disorder (DLD), they usually produce narratives with both impaired macro- and microstructure. It is therefore difficult to differentiate TD from DLD, on the basis of narrative production, especially in bilingual children. In this study, we examine whether a dynamic assessment (DA) task of narratives, using a pretest-teaching-posttest design, can differentiate TD from DLD, without disadvantaging bilinguals over monolinguals. Method: We recruited 118 French-speaking children (M[subscript age] = 8;5 [years;months]), with one experimental condition in which children benefited from a teaching phase (30 TD, 18 monolinguals and 12 bilinguals; 30 DLD, 15 monolinguals and 15 bilinguals) and one control condition (58 TD, 31 monolinguals and 27 bilinguals), in which children participated in another activity. In the pre- and posttest, children were asked to tell a story based on a series of pictures. During the teaching phase, an examiner asked children 12 specific questions about the story, targeting macro- and microstructural elements. Scores were attributed to the number of macro- and microstructural elements correctly produced and to the number of specific trained elements (TE) that were produced as a result of training. Results: Scores improved on macrostructure and on the number of TE following teaching for all groups of the experimental condition (TD and DLD), whereas there was no progress in children of the control condition. TD participants and participants with DLD differed on all measures in both pre- and posttest, with no differences between monolinguals and bilinguals. Conclusions: Our dynamic task led to both improved narrative skills and TD/DLD differentiation, with bilinguals not being disadvantaged. Our study thus supports the existing literature indicating that DA can be used to diagnose narrative deficits in children with DLD.

Children with developmental dyslexia (DD) display partially preserved morphology skills which they rely upon for reading and spelling. Therefore, we conducted explicit and intensive training of derivational morphology in French and Swiss individuals with DD, ages 9 to 14 years, in order to assess its effect on: morphological awareness, reading (speed and accuracy), and spelling. Our pre–posttest design included a group trained in derivational morphology and a group of children who continued their business-as-usual rehabilitation program with their speech-language therapist. Results showed effects on morphological awareness and on the spelling of complex words, with a large between-group effect size for trained items and a large to moderate effect size for untrained items. All these gains tended to be maintained over time on the delayed posttest, 2 months later. For reading, the results were more contrasted, with large between-group effect sizes for accuracy and speed for trained items, reducing to a small effect for accuracy on the delayed posttest. For untrained items, small effects were observed on accuracy (at both posttests) but not on speed. These results are very promising and argue in favor of using derivational morphology as a medium to improve literacy skills in French-speaking children and adolescents with DD. [ABSTRACT FROM AUTHOR]

Introduction: Patients on veno-arterial extracorporeal membrane oxygenation (V-A ECMO) support are at a high risk of hemorrhagic complications, including upper gastrointestinal bleeding (UGIB). The objective of this study was to evaluate the incidence and impact of this complication in V-A ECMO patients. Materials and methods: A retrospective single-center study (2013–2017) was conducted on V-A ECMO patients, excluding those who died within 24 h. All patients with suspected UGIB underwent esophagogastroduodenoscopy (EGD) and were analyzed and compared to the remainder of the cohort, from the initiation of ECMO until 5 days after explantation. Results: A total of 150 V-A ECMO cases (65 after cardiac surgery and 85 due to medical etiology) were included. 90% of the patients received prophylactic proton pump inhibitor therapy and enteral nutrition. Thirty-one patients underwent EGD for suspected UGIB, with 16 confirmed cases of UGIB. The incidence was 10.7%, with a median occurrence at 10 [7–17] days. There were no significant differences in clinical or biological characteristics on the day of EGD. However, patients with UGIB had significant increases in packed red blood cells and fresh frozen plasma needs, mechanical ventilation duration and V-A ECMO duration, as well as in length of intensive care unit and hospital stays. There was no significant difference in mortality. The only independent risk factor of UGIB was a history of peptic ulcer (OR = 7.32; 95% CI [1.07–50.01], p = 0.042). Conclusion: UGIB occurred in at least 1 out of 10 cases of V-A ECMO patients, with significant consequences on healthcare resources. Enteral nutrition and proton pump inhibitor prophylaxis did not appear to protect V-A ECMO patients. Further studies should assess their real benefits in these patients with high risk of hemorrhage. [ABSTRACT FROM AUTHOR]

Purpose: Typically developing (TD) bilingual children usually produce narratives with preserved macrostructure (i.e., narrative scheme) but with impaired microstructure (i.e., language complexity). As for monolingual and bilingual children with developmental language disorder (DLD), they usually produce narratives with both impaired macro- and microstructure. It is therefore difficult to differentiate TD from DLD, on the basis of narrative production, especially in bilingual children. In this study, we examine whether a dynamic assessment (DA) task of narratives, using a pretest–teaching–posttest design, can differentiate TD from DLD, without disadvantaging bilinguals over monolinguals. Method: We recruited 118 French-speaking children (Mage = 8;5 [years; months]), with one experimental condition in which children benefited from a teaching phase (30 TD, 18 monolinguals and 12 bilinguals; 30 DLD, 15 monolinguals and 15 bilinguals) and one control condition (58 TD, 31 monolinguals and 27 bilinguals), in which children participated in another activity. In the pre- and posttest, children were asked to tell a story based on a series of pictures. During the teaching phase, an examiner asked children 12 specific questions about the story, targeting macro- and microstructural elements. Scores were attributed to the number of macro- and microstructural elements correctly produced and to the number of specific trained elements (TE) that were produced as a result of training. Results: Scores improved on macrostructure and on the number of TE following teaching for all groups of the experimental condition (TD and DLD), whereas there was no progress in children of the control condition. TD participants and participants with DLD differed on all measures in both pre- and posttest, with no differences between monolinguals and bilinguals. Conclusions: Our dynamic task led to both improved narrative skills and TD/DLD differentiation, with bilinguals not being disadvantaged. Our study thus supports the existing literature indicating that DA can be used to diagnose narrative deficits in children with DLD. [ABSTRACT FROM AUTHOR]

By tracing the transformations of gender-based violence policies in France, this article highlights how they reflect neoliberal feminist dynamics. While the notion of 'neoliberal feminism' was developed to focus on the cultural and symbolic arena to analyse the changing representations of feminism, as well as the norms and subjectivities that were shaped by both a managerial and an egalitarian ethos, the role of the state in these processes was left aside. Therefore, the article aims at putting the state back into the analysis of neoliberal feminism by showing how state feminism has been driven in part by a neoliberal rationale when designing policies and has progressively excluded a structural perspective on the problem of gender-based violence. [ABSTRACT FROM AUTHOR]

The investigation of the mechanical behaviour of swelling claystones and shales is challenging because of their very low permeability and of their high sensitivity to changes in water content. The former makes it difficult to carry out triaxial tests with controlled homogeneous water pore pressure fields, and the latter results in some possible effects of swelling when unsaturated extracted specimens are re-saturated prior to being tested. This work presents some data from drained triaxial tests performed on specimens of Opalinus Clay, designated as host rock for radioactive waste disposal in Switzerland, extracted at shallow depth close to the city of Lausen. The data are compared to those recently published from undrained triaxial tests on specimens from the same place, and also to two sets of recent data independently obtained on Opalinus Clay specimens sourced from greater depth at the Mt Terri Underground Research Laboratory. By comparing the data of our drained tests on Lausen specimens to those from specific undrained tests in which swelling has been prevented, quite a good comparability in shear strength is observed at confining effective stresses larger than 5–6 MPa. This is related to the small magnitude of the swelling occurring above this stress during the specimen hydration in drained tests. The question of the possible linearity of the shear strength criterion at low stress is also discussed with respect to both our data and other published ones. It is suggested that undrained tests be also carried out at low confining stresses to investigate whether some perturbations due to hydration swelling occur in this area that could result in a nonlinear shape of the criterion. The change in Young modulus and Poisson coefficient with stress is also discussed, and the data on Opalinus Clay are compared to those of the Callovo–Oxfordian claystone from France, evidencing interesting similarities in terms of shear strength properties and Young's moduli. [ABSTRACT FROM AUTHOR]

Purpose: Streptococcus gallolyticus subspecies gallolyticus (SGG) is an opportunistic pathogen causing invasive infections in the elderly often associated with colon neoplasia. The prevalence of SGG in the stools of patients with normal colonoscopy (control) was compared with patients with colorectal adenomas (CRA) or with carcinomas (CRC) from stages I to IV. The presence of the pk s island encoding colibactin as well as other CRC-associated bacteria such as toxicogenic Bacteroides fragilis , Fusobacterium nucleatum , and Parvimonas micra was also investigated. Patients and Methods: Fecal samples collected in France between 2011 and 2016 from patients with normal colonoscopy (n = 25), adenoma (n = 23), or colorectal cancer at different stages (n = 81) were tested by PCR for the presence of SGG , B. fragilis , F. nucleatum , P. micra , and the pks island. Relative quantification of SGG , F. nucleatum , and P. micra in stools was performed by qPCR. Results: SGG prevalence was significantly increased in the CRC group. Our results also revealed i) a strong and significant increase of toxinogenic B. fragilis in patients with early-stage adenoma and of pks island at late-stage CRC and ii) increased levels of F. nucleatum and P. micra in the stools of CRC patients. Furthermore, the simultaneous detection of these five bacterial markers was only found in CRC patients. Conclusions: Our results indicate that the prevalence or relative levels of CRC-associated bacteria vary during CRC development. Among them, B. fragilis (bft +) was singled out as the sole pathobiont detected at the early adenoma stage. [ABSTRACT FROM AUTHOR]

The Callovo-Oxfordian (COx) claystone is considered as a candidate host rock for a deep geological radioactive waste repository in France. Due to the exothermic waste packages, the rock is expected to be submitted to temperatures up to 90 °C. The temperature rise induces deformations of the host rock, together with an increase in pore pressures, involving complex thermo-hydro-mechanical (THM) couplings. This study aims to better characterize the THM response of the COx claystone to temperature changes in the laboratory. To this end, claystone specimens were tested in a temperature controlled, high pressure isotropic compression cell, under stress conditions close to the in-situ ones. Thermal loads were applied on the specimens along different heating and cooling paths. A temperature corrected strain gage system provided precise measurements of the anisotropic strain response of the specimens. Drained and undrained thermal expansion coefficients in both transversely isotropic directions were determined. The measurement of pore pressure changes in undrained condition yielded the thermal pressurization coefficient. All parameters were analysed for their compatibility within the thermo-poro-elastic framework, and their stress and temperature dependency was identified. [ABSTRACT FROM AUTHOR]

In the framework of a deep geological radioactive waste disposal in France, the hydromechanical properties of the designated host rock, the Callovo-Oxfordian claystone (COx), are investigated in laboratory tests. Experiments presented in this study are carried out to determine several coefficients required within a transversely isotropic material model. They include isotropic compression tests, pore pressure tests, and deviatoric loading tests parallel and perpendicular to the bedding plane. We emphasize the adapted experimental devices and testing procedures, necessary to detect small strains under high pressures, on a material, which is sensitive to water and has a very low permeability. In particular, we discovered a significant decrease of elastic stiffness with decreasing effective stress, which was observed to be reversible. In both isotropic and deviatoric tests, a notable anisotropic strain response was found. The Young modulus parallel to bedding was about 1.8 times higher than the one perpendicular to the bedding plane. A notably low Poisson ratio perpendicular to the bedding plane with values between 0.1 and 0.2 was evidenced. While the anisotropy of the back-calculated Biot coefficient was found to be low, a significant anisotropy of the Skempton's coefficient was computed. The performed experiments provide an overdetermined set of material parameters at different stress levels. Using all determined parameters in a least square error regression scheme, seven independent elastic coefficients and their effective stress dependency are characterized. Parameters measured under isotropic loading are well represented by this set of coefficients, while the poroelastic framework with isotropic stress dependency is not sufficient to describe laboratory findings from triaxial loading. [ABSTRACT FROM AUTHOR]

Seeds of the parasitic weed Phelipanche ramosa are well adapted to their hosts because they germinate and form haustorial structures to connect to roots in response to diverse host-derived molecular signals. P. ramosa presents different genetic groups that are preferentially adapted to certain hosts. Since there are indications that microbes play a role in the interaction especially in the early stages of the interaction, we studied the microbial diversity harbored by the parasitic seeds with respect to their host and genetic group. Twenty-six seed lots from seven cropping plots of three different hosts—oilseed rape, tobacco, and hemp—in the west of France were characterized for their bacterial and fungal communities using 16S rRNA gene and ITS (Internal transcribed spacer) sequences, respectively. First seeds were characterized genetically using twenty microsatellite markers and phenotyped for their sensibility to various germination stimulants including strigolactones and isothiocyanates. This led to the distinction of three P. ramosa groups that corresponded to their host of origin. The observed seed diversity was correlated to the host specialization and germination stimulant sensitivity within P. ramosa species. Microbial communities were both clustered by host and plot of origin. The seed core microbiota was composed of seventeen species that were also retrieved from soil and was in lower abundances for bacteria and similar abundances for fungi compared to seeds. The host-related core microbiota of parasitic seeds was limited and presumably well adapted to the interaction with its hosts. Two microbial candidates of Sphingobacterium species and Leptosphaeria maculans were especially identified in seeds from oilseed rape plots, suggesting their involvement in host recognition and specialization as well as seed fitness for P. ramosa by improving the production of isothiocyanates from glucosinolates in the rhizosphere of oilseed rape. [ABSTRACT FROM AUTHOR]

Purpose: Our work investigates the production of 3rd-person accusative clitic pronouns in French-speaking typically developing (TD) children and children with developmental language disorder (DLD) following a novel working memory (WM) training program (12 hrs of effective training) that specifically targets the components of WM that have been shown to be impaired in children with DLD and to be directly related to the mastery of clitics (Delage & Frauenfelder, submitted for publication; Durrleman & Delage, 2016). Method: Sixteen TD children aged 5–12 years and 26 age-matched children with DLD completed our 8-week WM training program. Furthermore, an age-matched control group of 16 TD children and 17 children with DLD followed a scholastic training regime matched for intensity and frequency. Syntax and WM were assessed prior to and following the WM/scholastic training. Results: Significant posttraining WM gains were found in TD children and children with DLD who took part in the WM training, and the production rate of 3rd-person accusative clitics significantly increased in children with DLD following the WM training. No significant WM or syntax gains were observed in the control group. Conclusion: These findings are noteworthy as Melby-Lervåg and Hulme's (2013) meta-analysis concluded that existing WM training programs show short-lived generalized effects to other comparable measures of WM, but that there is no evidence that such training generalizes to less directly related tasks. That our study led to gains in skills that were not trained (i.e., syntax) suggests that a WM training regime that is firmly grounded in theory and that targets the specific mechanisms shown to underpin the acquisition of syntax may indeed provide effective remediation for children with DLD. [ABSTRACT FROM AUTHOR]

Background: While data from USA and Canada demonstrate an opioid overdose epidemic, very little nation-wide European studies have been published on this topical subject.Methods: Using a nationally representative sample of the French Claims database (>700,000 patients), the exhaustive nationwide hospital discharge database, and national mortality registry, all patients dispensed at least one prescription opioid (PO) in 2004-2017 were identified, to describe trends in PO analgesic use, shopping behaviour, opioid-related hospitalizations and deaths. Annual prevalence of PO use and shopping behaviour (≥1 day of overlapping prescriptions from ≥2 prescribers, dispensed by ≥3 pharmacies) was estimated.Results: In 2004-2017, the annual prevalence of weak opioid use codeine, tramadol and opium rose by 150%, 123%, and 244%, respectively (p < 0.05). Strong opioid use increased from 0.54% to 1.1% (+104%, p < 0.05), significantly for oxycodone (+1950%). Strong opioid use in chronic noncancer pain rose by 88% (p < 0.05) and 1180% for oxycodone. Opioid shopping increased from 0.50% to 0.67% (+34%, p < 0.05), associated with higher mortality risk HR = 2.8 [95% confidence interval (CI): 1.2-6.4]. Opioid-related hospitalizations increased from 15 to 40 per 1,000,000 population (+167%, 2000-2017), and opioid-related deaths from 1.3 to 3.2 per 1,000,000 population (+146%, 2000-2015).Conclusions: This study provided a first European approach to a nationwide estimation with complete access to several national registries. In 2004-2017 in France, PO use excluding dextropropoxyphene more than doubled. The increase in oxycodone and fentanyl use, and nontrivial increasing trend in opioid-related morbidity-mortality should prompt authorities to closely monitor PO consumption in order to prevent alarming increases in opioid-related morbidity-mortality.Significance: In 2004-2017, prescription opioid use in France at least doubled and oxycodone use increased particularly, associated with a nontrivial increase in opioid-related morbidity-mortality. Although giving no indication for an 'opioid epidemic,' these findings call for proper monitoring of opioid use. [ABSTRACT FROM AUTHOR]

Recent work exploring syntax in developmental dyslexia (DD) has identified morphosyntactic deficits, striking parallelisms between children with DD and specific language impairment (SLI). The question remains open if the underlying causes for such deficits are related to difficulties in phonology, which is affected in DD, or to working memory, as has been previously reported for SLI. We focus on the production of third person accusative clitic pronouns (ACC3) and of homophonous definite determiners in French-speaking children with DD and SLI as well as typically developing (TD) controls. If syntactic complexity modulates performance of DD children, as has already been shown for SLI, we predict children with DD to perform significantly worse on ACC3 compared to definite determiners, which are homophonous but syntactically simpler. In addition, if impairment in ACC3 stems from phonology or working memory difficulties, we expect ACC3 performance in both clinical groups to relate to performance on non-word repetition or forward/backward digit spans. We studied 2 groups of 21 children and adolescents, with DD and SLI (7-15 years) and age-matched TD controls. Results reveal significant weaknesses with ACC3 in DD and SLI groups compared to TD controls, but no difficulty for homophonous definite determiners, confirming a deficit relating specifically to syntactic complexity. As for links to phonology and working memory, a single correlation emerged between ACC3 and the backward digit span in SLI, but not in DD, suggesting different underlying sources for syntactic deficits in these populations. Clinical implications of these results are discussed. [ABSTRACT FROM AUTHOR]

Background: Neuropathic pain is difficult to treat, and the efficacy of recommended drugs remains limited. N-methyl-D-aspartate receptors are implicated, and antagonists are a pharmacological option. Ketamine is widely used in French pain clinics, but without consensus or recommendations. Furthermore, the association of ketamine with magnesium has been poorly studied. The aim of the present study is to evaluate the benefit of ketamine with or without magnesium in refractory neuropathic pain.Methods/design: A randomized, double-blind, crossover, placebo-controlled study will be performed in Clermont-Ferrand University Hospital, Clermont-Ferrand, France. The aim is to evaluate the effect of ketamine with or without magnesium in 22 patients with neuropathic pain. Intravenous ketamine/placebo, ketamine/magnesium sulfate, or placebo/placebo will be administered consecutively to each patient, in random order, once at 5-week intervals. The primary endpoint is the AUC of pain intensity assessed on a 0-10 Numeric Pain Rating Scale for a 5-week period. Data analysis will be performed on an intention-to-treat basis, and all statistical tests (except primary analysis) will be performed with an α risk of 5% (two-sided).Discussion: Considering the poor efficacy of the drugs available for neuropathic pain, ketamine with or without magnesium sulfate may be a valuable therapeutic option that needs to be standardized.Trial Registration: EudraCT number- 2015-000142-29 . Registered on April 9, 2015; version 1.4. [ABSTRACT FROM AUTHOR]

The concept of the chaîne opératoire was popularized in the English-speaking world for the first time in the Archaeological Review from Cambridge in 1990. At that time, the history of the integration of this concept into French prehistory had begun. It would take a few years for this process to be successfully completed and more years for the history of research in lithic technology to take this into account. However, the concept and its history have, since the 1990s, been the subject of particularly intriguing writing and rewriting issues. This article presents the state of knowledge on this matter 1) by exposing what could be called the 'official' version of this history and 2) by correcting it with concrete historiographical facts gathered in the literature. In doing so, it also speculates on the context and motivations of scholars involved in these projects of writing the concept of the chaîne opératoire. [ABSTRACT FROM AUTHOR]

The Callovo-Oxfordian (COx) claystone is considered in France as a possible host rock for the disposal of high-level long-lived radioactive waste at great depth. During the operational phase, the walls of the galleries and of the disposal cells will be successively subjected to desaturation induced by ventilation followed by resaturation once the galleries are closed. To better understand this phenomenon, a sound understanding of the water retention properties of the COx claystone is necessary. Following a previous study by the same group, this paper presents an investigation of microstructure changes in COx claystone under suction changes. Microstructure was investigated by means of mercury intrusion porosimetry tests on freeze-dried specimens previously submitted to various suctions. Along the drying path, the initial microstructure, characterised by a well-classified unimodal pore population around a mean diameter value of 32 nm, slightly changed with the same shape of the PSD curve and slightly moved towards smaller diameters (27-28 nm) at suctions of 150 and 331 MPa, respectively. The infra-porosity too small to be intruded by mercury (diameter smaller than 5.5 nm) reduced from 4.3 to 3.3 %. Oven drying reduced the mean diameter to 20 nm and the infra-porosity to 1 %. Wetting up to 9 MPa suction leads to saturation with no significant change in the PSD curve, whereas wetting at zero suction gave rise to the appearance of a large pore population resulting from the development of cracks with width of several micrometres, together with an enlargement of the initial pore population above the mean diameter. The concepts describing the step hydration of smectites (by the successive placement within the clay platelets along the smectite faces of 1, 2, 3 and 4 layers of water molecules with respect to the suction applied) appeared relevant to better understand the changes in microstructure of the COx claystone under suction changes. This also allowed to better define the status of water in claystones and shales containing smectite, with a distinction made between the water adsorbed within the clay platelets, and the free inter-platelet water involved in hydromechanical couplings through changes in pore pressure and water transfers. [ABSTRACT FROM AUTHOR]

In many countries, valproate is indicated for epilepsy only, whereas its derivative divalproex (DVP) and valpromide (VPM) are indicated for bipolar disorders only. DVP is composed of sodium valproate and valproic acid (VA) in a 1:1 molar ratio and VPM is a prodrug completely hydrolyzed in the gastric tract to VA. Whatever the drug, the absorbed and active substance is the valproate ion. In this article, we reviewed the potential reasons that might justify these different indications. We performed a literature review of comparative studies of efficacy, pharmacokinetic parameters, side effects and costs for VPA, DVP, and VPM. We found only studies comparing VA with DVP. None of the eight efficacy studies found differences in epilepsy or mood disorders. The ten studies of side effects reported a difference in terms of gastrointestinal effects, but inconsistently. The United States (US) summary of product characteristics and kinetic comparison studies reported bioequivalence between DVP and VA, but a longer Tmax for DVP, likely due to its gastro-resistant galenic form. VPM summary of product characteristics and pharmacokinetic studies revealed a lower bioavailability (80% vs. 100% for VA) and a delayed Tmax. There is an additional cost for using DVP or VPM as compared to VA (respectively +177% and +77% in France). The differences in indications between valproate derivatives do not seem justified. Interchangeability between VA and DVP in bipolar disorders seems possible, at identical dosage. VPM would require a closer dosing schedule and a 20% reduction in dosage when switching to valproate. [Display omitted] [ABSTRACT FROM AUTHOR]

The article discusses the study of Medieval literature from the area of Paris, France, with a focus on the textual analysis and historical content of works of fiction in novels from the Middle Ages. Topics include the historiography of studies of Romanesque novels, the origin of the novel as a literary genre during the Middle Ages, and the cultural, geographical, and social reasons for the novel's rise as a popular literary form. Collections of Medieval manuscripts from Paris are examined for their references to works of fiction.

The article examines the ways in which the French prosecution of Nazi war criminal Klaus Barbie has impacted French public life, in response to his trial of 1987, the 1994 opening of the Children of Izieu Memorial at the Izieu Memorial Museum in France, and the Museum's video installations on Barbie. Topics include the museum's film "Avec les enfants?," or "With the Children?," by Anne Grynberg on the Nazi killing of French Jewish children, and the impact of time on the memory of Barbie.

Abstract: The Callovo-Oxfordian (COx) argillite is a possible host rock for radioactive waste disposal in which the ANDRA underground laboratory of Bure (East of France) has been excavated. In this paper some aspects of the volume change behaviour of the COx argillite are investigated. To do so, high pressure oedometers with a maximum capacity of 113MPa have been used. In a first stage, swelling tests were carried out on samples initially compressed at constant initial water content (unsaturated) that were afterwards soaked under vertical loads, respectively, smaller and higher than the in-situ vertical stress. All samples exhibited swelling, even at stress higher than the in-situ stress. In a second stage, standard step-loading compression tests were carried out on samples previously saturated under the in-situ vertical load, so as to investigate the volume change behaviour under load cycles. The strain–stress curves obtained appear to be different to what is currently observed in overconsolidated or cemented clays, with no clear appearance of yield and pre-yield reversible behaviour. The volumetric behaviour during both compaction and swelling is interpreted in terms of damage created by the collapse of pores within a fragile matrix. The amount of swelling observed is related to the extent of damage. [Copyright &y& Elsevier]

Background: Hemoptysis is a common presenting symptom and cause of hospitalization in the department of respiratory diseases. In a number of patients with chronic obstructive pulmonary disease (COPD) presenting with this symptom, investigations fail to reveal a precise etiology. Little data are available regarding characteristics and outcome of COPD patients presenting with cryptogenic hemoptysis (CH). Objectives: Our study goal was to assess the functional characteristics of these subjects, the risk factors for CH and the severity of hemoptysis, as well as long-term outcome. Methods: For more than 1 year, we enrolled and followed a group of 39 consecutive COPD patients admitted to our center with CH. Results: Between 1988 and 2003, 39 patients with COPD were admitted for CH in which investigation failed to reveal an etiology. The mean age was 51.3 years. All subjects were active smokers. Twenty-one patients (54%) had at least 1 risk factor for prolonged bleeding. Patients with more severe airflow obstruction tended to have more severe bleeding. Bronchoscopy appeared as useful as a computed tomography in locating the bleeding site. Arterial embolization succeeded in controlling bleeding in all patients who underwent angiography. One patient experienced a relapse in bleeding at 2 months. One developed lung cancer after 1 year. Thirty-four patients were followed for an average of 5 years. Only 2 subjects experienced recurrent hemoptysis. None died. Conclusions: CH in patients with COPD is associated with a favorable short- and long-term outcome when managed with timely angiographic embolization. Long-term incidence of lung cancer was uncommon after an episode of CH, and recurrences of hemoptysis were rare. Copyright © 2009 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

We modeled the effects of climate change and two forest management scenarios on wood production and forest carbon balance in French forests using process-based models of forest growth. We combined data from the national forest inventory and soil network survey, which were aggregated over a 50 × 50-km grid, i.e., the spatial resolution of the climate scenario data. We predicted and analyzed the climate impact on potential forest production over the period 1960–2100. All models predicted a slight increase in potential forest yield until 2030–2050, followed by a plateau or a decline around 2070–2100, with overall, a greater increase in yield in northern France than in the south. Gross and net primary productivities were more negatively affected by soil water and atmospheric water vapor saturation deficits in western France because of a more pronounced shift in seasonal rainfall from summer to winter. The rotation-averaged values of carbon flux and production for different forest management options were estimated during four years (1980, 2015, 2045 and 2080). Predictions were made using a two-dimensional matrix covering the range of local soil and climate conditions. The changes in ecosystem fluxes and forest production were explained by the counterbalancing effect of rising CO2 concentration and increasing water deficit. The effect of climate change decreased with rotation length from short rotations with high production rates and low standing biomasses to long rotations with low productivities and greater standing biomasses. Climate effects on productivity, both negative and positive, were greatest on high fertility sites. Forest productivity in northern France was enhanced by climate change, increasingly from west to east, whereas in the southwestern Atlantic region, productivity was reduced by climate change to an increasing degree from west to east. [ABSTRACT FROM AUTHOR]

In the frame of ’OHANA project (phase II), IRCOM institute characterizes the 300-m long silica fibres which will link the Canada–France–Hawaii-Telescope and the Gemini telescope. In this paper, we report a method to compensate the differential chromatic dispersion between two 300-m long silica polarization-maintaining fibres. We experimentally show that the differential dispersion is not the same on each neutral axis of the fibre. Moreover, thanks to a channeled spectrum analysis, we are able to foresee the evolution of the contrast as a function of the wavelength and the spectral resolution over a given spectral band. Consequently, we are able to adjust the fibre lengths in order to maximize the contrast over J spectral window. [Copyright &y& Elsevier]

Focuses on the French media coverage of the September 11, 2001 terrorist attacks on the U.S. Description of the first photograph of the incident that appeared in the Internet; Details of how the tragedy was broadcast in the country; Common reactions to the disaster; Implications of the U.S. television coverage of the incident.

The POLA study (June 1995 through July 1997) is a population-based study on cataract and age-related macular degeneration (AMD) and their risk factors in 2584 residents of Sète (South of France), aged 60–95 years. Classification of AMD was performed on 50° fundus photographs, according to an international classification. The presence of cardiovascular disease and its risk factors was determined by interviewer-based questionnaire, clinical examination (anthropometry, blood pressure) and fasting plasma measurements. Using a logistic model adjusted for age and gender, late AMD was not significantly associated with a history of cardiovascular disease, diabetes, use of hypocholesterolemic drugs, hypertension, blood pressure or plasma lipids. Obese subjects (body mass index greater than 30kg/m²) had a 2.29-fold (95% confidence interval (CI): 1.00–5.23) and 1.54-fold (CI: 1.05–2.26) increased risk of late AMD and pigmentary abnormalities in comparison with lean subjects. Finally, the risk of soft drusen was decreased in those subjects with a history of cardiovascular disease (odds-ratio (OR) = 0.72, CI: 0.54–0.97), and increased with increasing levels of HDL-cholesterol (OR = 1.52, CI: 1.14–2.02). None of these results were modified by further adjustments for smoking, educational level and plasma alpha-tocopherol. These results need to be confirmed by other studies, which ideally should be longitudinal and prospective. [ABSTRACT FROM AUTHOR]

Abstract: Since July 2011, French legislation forbids the creation of transgenic or chimerical embryos. But, paradoxically, this prohibition receives no penalty. Therefore, a legal modification seems appropriate, which could also be the opportunity to extend to hybrid embryos some of the protective rules already applicable to human embryos. [Copyright &y& Elsevier]

In recent years, a vast array of literature has shown that more and more city centres are affected by retail decline, be it in Japan, Belgium, Britain, the United States, or in France, while urban peripheries benefit from expanding retail activities. In this paper, we first rely on an international state of the art review, which allows us to identify recurring main factors that explain retail decline (such as sectoral concentration and competition from e-commerce), as well as more contextual factors bringing changes in urban settings and consumption practices (like demographic and labour market dynamics, the size of cities, or the location of municipalities within cities). Secondly, we examine how these factors, when combined, contribute to explain the decline in a superior diversity mix of retail activities in small and medium-sized French towns and cities, for four periods of about ten years each, from 1975 to 2014. The decline in shop diversity affects about a third of the municipalities observed in each period. Our hypotheses regarding the role of demographic size, employment mobility and location are then discussed and compared with the information given by the literature review. • Many city centres are affected by retail decline, while peripheries benefit from expanding retail activities. • An international state of the art identifies the main factors explaining retail decline. • The article examines how these factors explain the decline of retail activities in France's Small and Medium-Sized Cities. • The hypotheses about the role of demographic size, employment and location are discussed. [ABSTRACT FROM AUTHOR]

Capture-recapture methods are increasingly used to determine the prevalence of numerous chronic conditions but have never been used in the context of chronic pain (CP). This study sought to provide up-to-date estimates of the prevalence of people experiencing CP ± neuropathic characteristics in France using the capture-recapture method. In 2013 to 2015, 3 data sources were used: the French prescription drug database (D-list), the national hospital discharge database (H-list), and the French pain center database (P-list). Patients aged 18 years and older treated with analgesic drugs for ≥6 months (D-list) or with a diagnosis of CP ± neuropathic characteristics (H- and P-lists) were included. Two successive capture-recapture analyses were conducted, with log-linear regression for each analysis performed. A total of 63,557 and 9852 distinct cases of CP and chronic neuropathic pain were captured, respectively. The estimated prevalence of CP and chronic neuropathic pain in the adults ranged from 27.2% (95% confidence interval: 26.1-28.4) to 32.7% (26.0-43.3) and from 5.55% (2.89-19.0) to 7.30% (6.40-8.41), respectively. Most patients were female, median ages were 67 (55-80) and 63 (51-76) years for chronic and neuropathic pain, respectively. The analgesic drugs most frequently used in CP patients were paracetamol (62.1%), weak opioids (39.7%), and nonsteroidal anti-inflammatory drugs (32.7%), whereas in neuropathic pain patients, anticonvulsants (45.3%), tricyclic antidepressants (18.1%), and serotonin-norepinephrine reuptake inhibitors (13.3%) were more frequently used. This first electronic health record-based study on CP using the capture-recapture method revealed a high prevalence of CP, with a significant proportion of neuropathic pain patients. [ABSTRACT FROM AUTHOR]

The architecture and chronology of Late Pleistocene to Holocene alluvial deposits in the lower Garonne have been studied in details based on data (boreholes, trenches, ground-penetrating radar profiles, numerical dating) collected in quarries and during archaeological surveys. The preserved alluvial bodies, dated between ca. 38 ka and present, show that the river retained a meandering or anabranching pattern throughout this period, associated with the formation of lateral accretion packages and scroll bars in the convexity of meanders. Valley incision in connection to the LGM low sea level reached up to 19 m in the study area, and occurred between ca. 26 and 18 ka. Since ca. 18 ka, the lateral migration of meanders widened the plain without any significant incision of the Oligocene marl bedrock. The Early-Middle Holocene was characterized by the development of highly sinuous meanders, while sinuosity decreased in a late phase including the Little Ice Age. Comparison with other lowland European rivers shows that the persistence of a meandering or anabranching pattern during MIS 2 is not an isolated case. The documented examples are associated with rivers typified by low valley slope, or situated in southern regions unaffected by permafrost and characterized by dense vegetation. The latter conditions would not have led to a drastic change in river discharge and bedload transport during the Last Glacial, as was the case for more northerly rivers where braiding seems to have been common. • Preserved alluvial bodies show dominant formation of lateral accretion packages. • Valley incision in connection to the LGM low sea level reached up to 19 m. • Persistence of a meandering or anabranching pattern during MIS 2 in southern Europe • No drastic change in river discharge and bedload transport during the Last Glacial [ABSTRACT FROM AUTHOR]

Abstract: The argillite extracted from Bure site (France) is proposed, after being crushed and compacted, as a possible sealing and backfill material in the French geological high-level radioactive waste disposal. In this study, the effects of the grain size distribution and the microstructure on the hydro-mechanical behaviour of the compacted crushed argillite have been investigated. The volume change properties were investigated by running one-dimensional compression tests under constant water content (2.4–2.8%) with loading–unloading cycles. Under various vertical stresses, water flooding tests were carried out under constant–volume condition. Depending on the vertical stress level, either swelling or collapse behaviour was observed in the sense that vertical stress increased or decreased upon flooding respectively. A clear effect of grain size distribution has been also identified: finer samples exhibit stiffer compression behaviour and higher swelling potential. To provide a microstructure insight into the macroscopic behaviour feature observed, both mercury intrusion porosimetry (MIP) and scanning electron microscopy (SEM) observations were performed, evidencing that: (i) at the same dry density, the size of inter-aggregate pores is larger for the coarser crushed material; (ii) mechanical compression only reduces the inter-aggregate porosity in the stress range considered; (iii) the micro-mechanisms governing the flooding under constant–volume condition include the swelling of the clay particles, the increase of the intra-aggregate pores and the collapse of the inter-aggregate pores. The results show a strong effect of the grain size distribution on the hydro-mechanical behaviour and thus the close link between the microstructure and the hydro-mechanical behaviour. [Copyright &y& Elsevier]

Examines the omega-3 polyunsaturated fatty acids (OPFA) in migraine prevention in France. Effect of OPFA on the inflammatory reactions and production of cytokines; Application of OPFA on the prophylactic treatment of migraine; Observation of placebo effect on the study group trial.

• Grey-scale soil image is an indicator of a soil density field. • The grain size distribution (GSD) is predicted by up-scaling the grey-scale image. • It is done by treating only densities above the fixed threshold while up-scaling. • The representation of grains at different resolutions follows a multifractal law. • This multifractal GSD model shows rather good agreement with dry sieving data. Previous works related to the application of the multifractal theory for analyzing the grain size distribution (GSD), showed the potential of this approach to deal with this complex issue. However, absence of the practical application of this kind of statistical analysis raised some doubts among the soil scientists. Compared to the experimental dry sieving method, which is based on mass representations of different grain sizes, the approach presented in this work relies on the analysis of grain densities (density indicators) scanned by means of X-ray CT (Computed Tomography). By reducing the resolution of the scanned soil image(s), the cumulative representation of solid particles equal to or larger than the actual discretization element can be determined, and described analytically by means of the universal multifractals (UM). For validation of the new UM approach, the X-ray CT results of three different soils were used: the volcanic substrate covering Green Wave (a green roof of Champs-sur-Marne in France), and two horizons of the soil collected from the low land mountain area of Sierra de Guadarrama in Spain. Comparison between the proposed UM model and the experimental data of these three materials confirms that the GSD can be reasonably well predicted from the scanned images of soils covering wide range of grain sizes. The UM model, unlike the fractal-based models, accounts for fractal dimension that depends on grain size, and hence, based on the preliminary results presented in this work, it could be rather useful in case of multi-modal soils whose GSD curves are described with multiple fractal dimensions. [ABSTRACT FROM AUTHOR]

Some observations of human parasitism by Dirofilaria (Nochtiella) repens are frequently enough reported but they are also individually reported by different authors. Nïmes's geographical situation makes of it a privileged observatory for this helminthiasis. The worm's maturity varies depending on the subjects: the sensitivity of those and the clinical reactions are of a large variety. The ones that seem to be constant are the parasit's migrations in the different territories during a lot of months. It is the case in the observation reported here; in another article, we have shown the possibility of an intraperitoneal migration which discovery can be only of an extreme fate. Next to some noisy manifestations, other cases stayed quiet advise the adaptation of some autochtones submissed to iteratif infestations.

Prevalence analysis in the Gard; fluctuations according to seasons, age and sex. Statement a excystation method after passage in a induction solution; observations and excystation rate. Cysts resistance study in exterior middle at various temperature: at dry from -5 degrees C to 40 degrees C, in fresh water from -5 degrees C to 20 degrees C and in sea water at 10 degrees and 20 degrees C. Epidemiologic consequences.