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Prognostic factors for epithelial ovarian cancers (EOCs) are in particular clinical factors such as pathology staging at diagnosis (FIGO stages), genetic mutation, or histological phenotypes. In the present study, FIGO stage, tumor residue after surgery, and body mass index were clinical predictors of recurrence-free survival (RFS). Nonetheless, a number of studies support a lipid metabolism disorder in ovarian cancer patients. The objective of this pilot study was to explore whether fatty acid composition of adipose reflecting the qualitative dietary intake and fatty acids metabolism may be associated with RFS. Forty-six women with EOCs and six with borderline ovarian tumors between March 2017 and January 2020 were included in this prospective study at Tours university teaching hospital (central France). The patients involved in the present study are part of the METERMUS trial (clinicaltrials.gov NCT03027479). Adipose tissue specimens from four abdominal locations (superficial and deep subcutaneous, visceral (pericolic), and omental) were collected during surgery or exploratory laparoscopy. A fatty acid profile of adipose tissue triglycerides was established by gas chromatography. Fatty acids composition was compared among the four locations using nonparametric Friedman's ANOVA test for repeated measures. Median follow-up of EOC patients was 15 months and patients' RFS was analyzed using Kaplan–Meier survival curves and log-rank test by separating patients into two groups according to median fatty acid levels. The content of long-chain saturated fatty acids (SFAs) was increased and that of long-chain polyunsaturated fatty acids (PUFAs) decreased in deep versus superficial subcutaneous adipose tissue in EOC patients. Nevertheless, the content of total SFAs was ~28%, monounsaturated fatty acids (MUFAs) ~55%, PUFAs n-6 ~11.5%, and PUFAs n-3 about 1.3%, whatever the adipose tissue. When EOC patients were separated into two groups by median fatty acid content, total PUFAs (n-6+n-3) levels, whatever the adipose tissue, were positively and independently associated with RFS. RFS was about two times longer in EOC patients with high versus low total PUFA content (median survival: 12 vs. 27 months, p = 0.01 to <0.0001 according to the tissue). Content of total PUFAs (n-6+n-3) in abdominal adipose tissue (visceral and subcutaneous) are new prognostic factors in EOC. [ABSTRACT FROM AUTHOR]

Objective: Prostate cancer is the commonest cancer in men in France, and its incidence increases with age. It occupies 4th place in terms of mortality. The Limousin region, with the oldest population in France, established a regional registry of new cases of cancers in 1998. The objective of this study was to analyse the prostate cancer incidence and mortality data in the Limousin region for 1998., Material and Methods: Based on the cancer registry data and martality data of the department of information on medical causes of death, a registry was established for all new of prostate cancer and all cases of prostate cancer death in patients living in the Limousin region in 1998. Standardized incidence and mortality rates were compared with French data., Results: The crude incidence rate detected in the Limousin region was 149.5 per 100,000 inhabitants and the standardized rate compared to the French population was 124. These rates were significantly higher than those reported in France. The mortality rate from prostate cancer in the Limousin region was 29.2 deaths per 100,000 inhabitants and was higher than that reported for France as a whole., Conclusion: In view of the data for 1998, prostate cancer is a major public health problem in the Limousin region. This excess incidence could be related to the methodology used, the increased awareness of general practitioners of the problems of prostate cancer, who do not hesitate to request individual screening by prostatic-specific antigen (PSA) or the presence of specific risk factors in the Limousin region. Further studies must be conducted in the Limousin region.