1. Failure of dihydroartemisinin-piperaquine treatment of uncomplicated Plasmodium falciparum malaria in a traveller coming from Ethiopia.
- Author
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Gobbi F, Buonfrate D, Menegon M, Lunardi G, Angheben A, Severini C, Gori S, and Bisoffi Z
- Subjects
- Adult, Ethiopia, France, Humans, Military Personnel, Treatment Failure, Antimalarials administration & dosage, Artemisinins administration & dosage, Malaria, Falciparum complications, Malaria, Falciparum drug therapy, Overweight complications, Quinolines administration & dosage
- Abstract
Background: Artemisinin combination therapy (ACT) is used worldwide as the first-line treatment against uncomplicated Plasmodium falciparum malaria. Despite the success of ACT in reducing the global burden of malaria, the emerging of resistance to artemisinin threatens its use., Case Report: This report describes the first case of failure of dihydroartemisinin-piperaquine (DHA-PPQ) for the treatment of P. falciparum malaria diagnosed in Europe. It occurred in an Italian tourist returned from Ethiopia. She completely recovered after the DHA-PPQ treatment but 32 days after the end of therapy she had a recrudescence. The retrospective analysis indicated a correct DHA-PPQ absorption and genotyping demonstrated that the same P. falciparum strain was responsible for the both episodes., Conclusion: In consideration of the growing number of cases of resistance to ACT, it is important to consider a possible recrudescence, that can manifest also several weeks after treatment.
- Published
- 2016
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