1. [Maurice Raynaud (1834-1881) and the Mystery of "Raynaud's Phanomenon"].
- Author
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Koehler U, Portig I, Hildebrandt O, and Koehler NA
- Subjects
- Fingers physiopathology, France, History, 19th Century, Humans, Male, Physicians history, Raynaud Disease history, Raynaud Disease physiopathology
- Abstract
Maurice Raynaud first described color changes and symptoms of the fingers due to cold-induced vasospasm and restricted blood flow in his medical school thesis in 1862. Raynaud's phenomenon is common and exists as an uncomplicated primary Raynaud phenomenon and a Raynaud phenomenon secondary to underlying diseases and medication. Mechanisms contributing to altered vasoconstrictor activity are endothelial and not-endothelial. Cold-induced vasospasm is probably a thermoregulatory problem and effects are mediated by sympathetic activity and selective stimulation of alpha
2c -adrenoreceptors., Competing Interests: Die Autoren geben an, dass kein Interessenkonflikt besteht., (© Georg Thieme Verlag KG Stuttgart · New York.)- Published
- 2019
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