1. The 14q restless legs syndrome locus in the French Canadian population.
- Author
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Levchenko A, Montplaisir JY, Dubé MP, Riviere JB, St-Onge J, Turecki G, Xiong L, Thibodeau P, Desautels A, Verlaan DJ, and Rouleau GA
- Subjects
- Canada, Chromosome Mapping, Female, France ethnology, Genes, Dominant, Genes, Recessive, Genetic Linkage, Genotype, Humans, Lod Score, Male, Pedigree, Chromosomes, Human, Pair 14 genetics, Family Health, Genetic Predisposition to Disease, Restless Legs Syndrome genetics
- Abstract
A new restless legs syndrome locus on chromosome 14 recently has been reported in one family of Italian origin. Our study aimed to replicate this finding and determine the importance of this locus in the French Canadian population. Markers spanning the region were genotyped in 14 large families and linkage assessed using two-point and multipoint logarithm of odds scores. Possible linkage to this locus was found in one of our kindreds providing support for the existence of this locus and indicating that this locus may be responsible for a small fraction of French Canadian restless legs syndrome.
- Published
- 2004
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