1. Transmission-blocking immunity to Plasmodium falciparum in malaria-immune individuals is associated with antibodies to the gamete surface protein Pfs230.
- Author
-
Healer J, McGuinness D, Carter R, and Riley E
- Subjects
- Animals, Anopheles parasitology, Antibodies, Protozoan blood, Antigens, Surface immunology, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Female, Gambia, Humans, Image Processing, Computer-Assisted, Malaria, Falciparum prevention & control, Malaria, Falciparum transmission, Membrane Glycoproteins immunology, Models, Statistical, Precipitin Tests, Protozoan Vaccines administration & dosage, Protozoan Vaccines immunology, Statistics, Nonparametric, Antibodies, Protozoan immunology, Antigens, Protozoan immunology, Malaria, Falciparum immunology, Plasmodium falciparum immunology, Protozoan Proteins immunology
- Abstract
Malaria-immune human sera were tested for their ability to affect the infectivity of Plasmodium falciparum gametocytes to Anopheles stephensi mosquitoes. Transmission-reducing effects of the sera were associated with the presence of antibodies to the gamete surface protein, Pfs230. Enhancement of transmission, manifest as elevated numbers of oocysts relative to controls, was observed for a number of sera, but was not found to be associated with antibodies against Pfs230. These results confirm that Pfs230 is a possible candidate for inclusion in a transmission-blocking malaria vaccine.
- Published
- 1999
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