1. Molecular epidemiology of respiratory syncytial virus in The Gambia.
- Author
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Cane PA, Weber M, Sanneh M, Dackour R, Pringle CR, and Whittle H
- Subjects
- Amino Acid Sequence, Base Sequence, Developing Countries, Gambia epidemiology, Genetic Variation genetics, Genotype, Humans, Incidence, Infant, Molecular Epidemiology, Molecular Sequence Data, Phylogeny, Population Surveillance, Respiratory Syncytial Virus, Human classification, Restriction Mapping, Seasons, Serotyping, DNA, Viral genetics, Respiratory Syncytial Virus Infections epidemiology, Respiratory Syncytial Virus Infections virology, Respiratory Syncytial Virus, Human genetics
- Abstract
Respiratory syncytial virus (RSV) infection in The Gambia occurs seasonally in association with the rainy season. This study examined the genetic variability of RSV isolates from four consecutive epidemics from 1993-6. Each epidemic was made up of a number of variants which were replaced in subsequent epidemics. Analysis of attachment (G) protein gene sequences showed that isolates were closely related to those observed in the rest of the world. However, many isolates from 1993 and 1994 were unlike other isolates observed in the developed world during this period and were more similar to isolates from 1984 in Europe. In addition, the most commonly observed genotype in the UK in the 1990s was not detected in The Gambia during this period. more...
- Published
- 1999
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