1. [Graded chemotherapy and reduced radiotherapy in Hodgkin's disease in childhood. Intermediate report on the cooperative HD 82 therapy study].
- Author
-
Strauch S, Schellong G, and Wannenmacher M
- Subjects
- Adolescent, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Austria, Child, Child, Preschool, Combined Modality Therapy, Cyclophosphamide administration & dosage, Doxorubicin administration & dosage, Drug Administration Schedule, Female, Germany, West, Hodgkin Disease drug therapy, Hodgkin Disease radiotherapy, Humans, Male, Neoplasm Staging, Prednisone administration & dosage, Procarbazine administration & dosage, Splenectomy, Vincristine administration & dosage, Hodgkin Disease therapy
- Abstract
The results of 111 children with Hodgkin's disease, who were treated with chemotherapy of different intensity and reduced radiotherapy (Cooperative Therapy Study HD 82, 12/81 - 9/83) are presented. There is no evidence that reduction of radiotherapy and selective splenectomy (splenectomy only in case of high probability of splenic involvement) induce a higher rate of relapses. All 87 patients with pathological stage I, II and IIIA are in first remission. 2 of 24 patients with stage IIIB/IV died of sepsis, 1 of those 24 patients relapsed. Splenectomy could be omitted in 2/3 of patients, in 75% of splenectomy splenic involvement was proved. 7% of all children get splenic irradiation.
- Published
- 1984
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