1. High-risk pregnancies in Diamond-Blackfan anemia: a survey of 64 pregnancies from the French and German registries.
- Author
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Faivre L, Meerpohl J, Da Costa L, Marie I, Nouvel C, Gnekow A, Bender-Götze C, Bauters F, Coiffier B, Peaud PY, Rispal P, Berrebi A, Berger C, Flesch M, Sagot P, Varet B, Niemeyer C, Tchernia G, and Leblanc T
- Subjects
- Anemia prevention & control, Anemia, Diamond-Blackfan drug therapy, Aspirin therapeutic use, Data Collection, Female, France, Germany, Humans, Pregnancy, Pregnancy Complications drug therapy, Pregnancy Complications prevention & control, Pregnancy Complications, Cardiovascular drug therapy, Pregnancy Complications, Cardiovascular etiology, Registries, Retrospective Studies, Anemia, Diamond-Blackfan complications, Pregnancy Complications etiology
- Abstract
We reviewed 64 pregnancies in 26 women with Diamond-Blackfan anemia (DBA) included in the French and German DBA registries. Complications were seen in 42 pregnancies (66%) and included abortion, pre-eclampsia, in utero fetal death, intrauterine growth retardation, retroplacental hematoma, pre-term delivery and fetal malformations. Of the 34 children (53%) born alive, 13 had DBA. No correlations were found between pregnancy outcome and features of either maternal or child DBA. Pregnancies in DBA-affected women are at high risk, especially for complications likely to be of vascular-placental origin. Careful monitoring with prevention of severe anemia and early introduction of aspirin is suggested.
- Published
- 2006