1. Effects of acyl-coenzyme A binding protein (ACBP)/diazepam-binding inhibitor (DBI) on body mass index.
- Author
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Joseph A, Chen H, Anagnostopoulos G, Montégut L, Lafarge A, Motiño O, Castedo M, Maiuri MC, Clément K, Terrisse S, Martin AL, Vaz-Luis I, Andre F, Grundler F, de Toledo FW, Madeo F, Zitvogel L, Goldwasser F, Blanchet B, Fumeron F, Roussel R, Martins I, and Kroemer G
- Subjects
- Animals, Cohort Studies, Female, France, Germany, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Obesity metabolism, Obesity pathology, Body Mass Index, Body Weight drug effects, Diazepam Binding Inhibitor pharmacology
- Abstract
In mice, the plasma concentrations of the appetite-stimulatory and autophagy-inhibitory factor acyl-coenzyme A binding protein (ACBP, also called diazepam-binding inhibitor, DBI) acutely increase in response to starvation, but also do so upon chronic overnutrition leading to obesity. Here, we show that knockout of Acbp/Dbi in adipose tissue is sufficient to prevent high-fat diet-induced weight gain in mice. We investigated ACBP/DBI plasma concentrations in several patient cohorts to discover a similar dual pattern of regulation. In relatively healthy subjects, ACBP/DBI concentrations independently correlated with body mass index (BMI) and age. The association between ACBP/DBI and BMI was lost in subjects that underwent major weight gain in the subsequent 3-9 years, as well as in advanced cancer patients. Voluntary fasting, undernutrition in the context of advanced cancer, as well as chemotherapy were associated with an increase in circulating ACBP/DBI levels. Altogether, these results support the conclusion that ACBP/DBI may play an important role in body mass homeostasis as well as in its failure.
- Published
- 2021
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