1. Benign acute viral myositis in African migrants: A clinical, serological, and pathological study.
- Author
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Pancheri, Elia, Lanzafame, Massimiliano, Zamò, Alberto, Angheben, Andrea, Sartoris, Silvia, Zorzi, Antonella, Boaretti, Marzia, Signoretto, Caterina, Guglielmi, Valeria, Ferrari, Sergio, Tonin, Paola, and Vattemi, Gaetano
- Subjects
AUTOANTIBODIES ,CARRIER proteins ,CREATINE kinase ,ENZYMES ,HISTOCOMPATIBILITY antigens ,IMMIGRANTS ,IMMUNOGLOBULINS ,MACROPHAGES ,MYOSITIS ,RHABDOMYOLYSIS ,T cells ,VIRAL antibodies ,VIRUS diseases ,DISEASE complications - Abstract
Background: Several viruses have been described as causes of acquired inflammatory myopathies; however, the mechanisms by which they cause muscle disease are still unclear. The aim of this study was to describe the laboratory features of benign acute myositis in a small case series.Methods: A detailed pathological and serological analysis was performed in five African migrants who developed an acute viral myositis complicated by rhabdomyolysis.Results: Muscle biopsies clearly documented an inflammatory myopathy with histological features similar to polymyositis including CD8+ T cells surrounding and invading nonnecrotic muscle fibers, CD68+ macrophages and major histocompatibility complex class I antigen upregulation. In addition, positivity for myositis-specific antibodies (MSA), in particular anti-aminoacyl tRNA synthetases, was found in the serum of two patients.Conclusions: Our study demonstrated that T-cell mediated injury occurs in muscle of patients with acute viral myositis, and that MSA may be present in the serum of these patients. [ABSTRACT FROM AUTHOR]- Published
- 2019
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