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Medicinal plants play a vital role in human life. The plant-based botanicals are considered to be safer, selective, and effective to conventional and synthetic chemicals used for the same purposes. There are huge number of bioactive plants around the globe which needs to be explored for their potential as herbal alternatives to traditional chemicals. In the present study, the methanolic extracts of Anaphalis nepalensis (AN), Anaphalis virgata (AV), Artemisia foetida (AF), and Anthemis cotula (AC) were collected from Gilgit-Baltistan. The main plant extracts were further fractionated into n-hexanes (H), dichloromethane (D) and aqueous (A) fractions. All these fractions were analyzed for their nematocidal, insecticidal, anti-inflammatory, and anti-cancer activities. All three fractions of AC, AV, and AF showed excellent nematocidal activity against Meloidogyne incognita (90, 94, 95%, respectively) at conc. of 1% after 72 h of the treatment. Similarly, AV-D and AC-D showed excellent anti-inflammatory response with IC50 values of 20 and 32 through inhibition of ROS. The cytotoxic activities of AC-H, AC-D, and AC-A against Hela tumor cell lines was found active with IC50 values of 22.7, 12.7, and 7.6, respectively. [ABSTRACT FROM AUTHOR]