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A rule-based, weight-of-evidence approach for assessing contaminated sediment on a site-by-site basis in the Laurentian Great Lakes is described. Information from four lines of evidence -- surficial sediment chemistry, laboratory toxicity, invertebrate community structure and invertebrate tissue biomagnification -- is integrated within each line to produce a pass ('-') or fail ('+') conclusion, then combined across lines resulting in one of 16 outcome scenarios. For each scenario, the current status of the site, interpretation, and management recommendations are given. Management recommendation(s) can range from no action to risk management required (9 of the 16 scenarios). Within each line of evidence, the strength of each response can also be ranked (e.g., score of 1 to 4), providing managers with more information to aid decision options. Other issues that influence scientific management recommendations include site stability, subsurface contamination and spatial extent of effects. The decision framework is intended to be transparent, comprehensive (incorporating exposure, effect, weight-of-evidence, and risk), and minimally uncertain. [ABSTRACT FROM AUTHOR]