1. Transferable cefoxitin resistance in enterobacteria from Greek hospitals and characterization of a plasmid-mediated group 1 beta-lactamase (LAT-2).
- Author
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Gazouli M, Tzouvelekis LS, Prinarakis E, Miriagou V, and Tzelepi E
- Subjects
- Amino Acid Sequence, Base Sequence, Citrobacter freundii drug effects, Citrobacter freundii enzymology, Citrobacter freundii genetics, Conjugation, Genetic, Drug Resistance, Microbial, Enterobacter drug effects, Enterobacter enzymology, Enterobacter genetics, Enterobacteriaceae enzymology, Escherichia coli drug effects, Escherichia coli enzymology, Escherichia coli genetics, Greece, Microbial Sensitivity Tests, Molecular Sequence Data, Plasmids, Cefoxitin pharmacology, Cephamycins pharmacology, Cross Infection microbiology, Enterobacteriaceae drug effects, Enterobacteriaceae genetics, Penicillinase genetics
- Abstract
Cefoxitin resistance in Klebsiella pneumoniae from Escherichia coli strains isolated in Greek hospitals was found to be due to the acquisition of similar plasmids coding for group 1 beta-lactamases. The plasmids were not self-transferable but were mobilized by conjugative plasmids. These elements have also been spread to Enterobacter aerogenes. The most common enzyme was a Citrobacter freundii-derived cephalosporinase (LAT-2) which differed from LAT-1 by three amino acids.
- Published
- 1996
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