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1. One antigen mismatched related donor bone marrow transplant in a patient with acute lymphoblastic leukaemia and beta-thalassaemia major: potential cure of both marrow disorders.

Author

Kottaridis PD, Peggs K, Lawrence A, Verfuerth S, Chatterjee R, Telfer P, Porter JB, Mackinnon S, and Goldstone AH

Subjects
Adult, Bone Marrow Diseases immunology, Bone Marrow Diseases therapy, Bone Marrow Transplantation adverse effects, Disease-Free Survival, Greece ethnology, Humans, Isoantigens adverse effects, Male, Microsatellite Repeats, Precursor Cell Lymphoblastic Leukemia-Lymphoma complications, Precursor Cell Lymphoblastic Leukemia-Lymphoma immunology, Risk Factors, Tissue Donors, Transplantation Chimera, Transplantation, Homologous, beta-Thalassemia complications, beta-Thalassemia immunology, Blood Grouping and Crossmatching adverse effects, Bone Marrow Transplantation immunology, Precursor Cell Lymphoblastic Leukemia-Lymphoma therapy, beta-Thalassemia therapy
Abstract

We report a case of a 34-year-old man with T-ALL and beta-thalassaemia major who underwent a one antigen mismatched related donor bone marrow transplant. Five months post transplant chimeric studies revealed full donor haemopoiesis and the patient remains leukaemia and thalassaemia free at 12 months post transplant. Cumulative risk factors contributing to the increased transplant-related mortality in patients with two different marrow disorders are discussed.

Published
2000
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