1. A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam.
- Author
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Wada M, Ren CH, Koyama S, Arawaka S, Kawakatsu S, Kimura H, Nagasawa H, Kawanami T, Kurita K, Daimon M, Hirano A, and Kato T
- Subjects
- Aged, Aged, 80 and over, Alzheimer Disease pathology, Animals, Dementia pathology, Female, Guam, Hippocampus chemistry, Hippocampus pathology, Humans, Immunohistochemistry, Inclusion Bodies chemistry, Inclusion Bodies pathology, Male, Middle Aged, Parkinsonian Disorders pathology, Peptide Fragments metabolism, Rats, Alzheimer Disease metabolism, Dementia metabolism, Neuropeptides analysis, Parkinsonian Disorders metabolism, Protein Precursors analysis, tau Proteins analysis
- Abstract
The deposition of tau inclusions is one of the neuropathological hallmarks in neurodegenerative disorders with dementia. We have reported that the N-terminal fragment of a human granin-like neuroendocrine peptide precursor (N-proSAAS) is accumulated in Pick bodies. However, it is unknown whether N-proSAAS is widely accumulated in tau inclusions in other tauopathies. Here, we performed an immunohistochemical examination using antibodies against both the N- and C-terminal sequence of proSAAS in the brains of patients with Alzheimer's disease and parkinsonism-dementia complex on Guam. The antibody against N-proSAAS immunostained neurofibrillary tangles and neuritic plaques in both diseases, whereas the antibody against the C-terminal sequence of proSAAS did not. The results of the present study suggest that N-proSAAS or proSAAS-like molecules were trapped within the tau fibrils and accumulated in tau inclusions.
- Published
- 2004
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