1. Hemoglobin H Disease in Guangxi Province, Southern China: Clinical Review of 357 Patients.
- Author
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Xiao-Llin Yin, Xin-Hua Zhang, Tian-Hong Zhou, Tian-Lang Zhang, Rui-Gui Luo, Li Wang, Ya-Li Zhou, Yong-Sheng Chen, Xiang-Jin Kong, Yuan-Yuan He, Lin Peng, Li-Biao Lu, Su-Ping Fang, Zhi-Kui Wu, and Bo Liang
- Subjects
THALASSEMIA ,DIAGNOSIS ,ANEMIA - Abstract
The clinical characteristics of 357 patients with hemoglobin H (HbH) disease from the Guangxi province of Southern China were studied. One hundred and ninety-one (53.3%) patients were diagnosed with HbH-Constant Spring, 19 were diagnosed with HbH Westmead. Ten patients were shown to have coinherited HbH-Constant Spring/QS with a β-thalassemia mutation. Coinheritance of the β-thalassemia gene does not alleviate anemia (8.2 ± 2.3 vs. 7.6 ± 1.7 g/dl, p = 0.276), or influence age at diagnosis (20.2 ± 19.6 vs. 12.9 ± 11.0 years, p = 0.276). Ferritin levels were significantly higher in the group of patients with the nondeletional form of the disease (475 ± 719 vs. 249 ± 264 ng/ml, p = 0.005). Copyright © 2010 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2010
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