Conducting suitability assessment for sugarcane cultivation is of great significance for optimizing the sugarcane cultivation structure and industrial layout. In this paper, based on the requirements of sugarcane growth and development on climate, terrain, and other environmental conditions, as well as the influence of natural disasters, a total of 11 specific indicators in terms of climate factor, terrain factor, and disaster factor were selected to construct a sugarcane cultivation suitability assessment system based on the analytic hierarchy process (AHP). Then, using Guangxi Province, China, as an example, a suitability assessment for sugarcane cultivation was conducted using multi-source data on climate, terrain, and hazards over the past 30 years. The results showed that among 11 indicators, including annual average temperature, elevation had the largest contribution rate, followed by precipitation during the period of ≥20 °C, slope, and the autumn drought frequency. From the spatial distribution, 37% of the provincial regions were suitable for sugarcane cultivation, mainly distributed in Chongzuo City, Nanning City, Qinzhou City, and Beihai City. In total, 44% of the provincial regions were moderately suitable for sugarcane cultivation, mainly distributed in Hezhou City, Laibin City, and Liuzhou City. Additionally, only 19% of the provincial regions were unsuitable for sugarcane cultivation, mainly distributed in Baise City, Hechi City, and Guilin City, with the terrain factor being the main influencing factor of sugarcane suitability assessment. In order to make reasonable use of land resources and increase sugarcane yield, it is suggested that sugarcane cultivation areas should be adjusted to the central and southern regions such as Chongzuo City, Nanning City, Beihai City, and Qinzhou City, and other industries should be developed in the northern regions which are not suitable for sugarcane cultivation. [ABSTRACT FROM AUTHOR]