1. Fine-mapping scan of bipolar disorder susceptibility loci in Latino pedigrees.
- Author
-
Gonzalez S, Villa E, Rodriguez M, Ramirez M, Zavala J, Armas R, Dassori A, Contreras J, Raventós H, Flores D, Jerez A, Ontiveros A, Nicolini H, and Escamilla M
- Subjects
- Actin-Related Protein 3 genetics, Actin-Related Protein 3 metabolism, Adult, Bipolar Disorder psychology, Chromosome Mapping methods, Costa Rica, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases genetics, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases metabolism, Female, Genetic Linkage genetics, Genetic Predisposition to Disease genetics, Genome-Wide Association Study methods, Genotype, Guatemala, Hispanic or Latino genetics, Humans, Lod Score, Male, Mexico, Middle Aged, Muscle Proteins genetics, Muscle Proteins metabolism, Polymorphism, Single Nucleotide genetics, Psychotic Disorders psychology, SKP Cullin F-Box Protein Ligases genetics, SKP Cullin F-Box Protein Ligases metabolism, United States, Bipolar Disorder genetics, Chromosomes, Human, Pair 2 genetics, Psychotic Disorders genetics
- Abstract
We previously identified bipolar disorder (BD) susceptibility loci on 8q24, 14q32, and 2q12-14 in a genome-wide nonparametric linkage screen in a Latino cohort. We now perform a fine mapping analysis using a dense map of additional SNPs to identify BD susceptibility genes within these regions. One thousand nine hundred and thirty-eight individuals with Latino ancestry (880 individuals with BD Type I or Schizoaffective, Bipolar Type) from 416 Latino pedigrees from the United States, Mexico, Costa Rica, and Guatemala were genotyped with 3,074 SNPs to provide dense coverage of the 8q24 (11.5 cM), 14q32 (7.5 cM), and 2q12-14 (6.5 cM) chromosomal loci. Single-marker association tests in the presence of linkage were performed using the LAMP software. The top linkage peak (rs7834818; LOD = 5.08, p = 3.30E - 5) and associated single marker (rs2280915, p = 2.70E - 12) were located within FBXO32 on 8q24. On chromosome 2, the top linkage peak (rs6750326; LOD = 5.06, p = 3.50E - 5) and associated single marker (rs11887088, p = 2.90E - 6) were located in intragenic regions near ACTR3 and DPP10. None of the additional markers in the region around chromosome 14q32 met significance levels for linkage or association. We identified six SNPs on 2q12-q14 and one SNP in FBXO32 on 8q24 that were significantly associated with BD in this Latino cohort., (© 2019 Wiley Periodicals, Inc.)
- Published
- 2019
- Full Text
- View/download PDF