1. HIV-2 capsids distinguish high and low virus load patients in a West African community cohort.
- Author
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Onyango CO, Leligdowicz A, Yokoyama M, Sato H, Song H, Nakayama EE, Shioda T, de Silva T, Townend J, Jaye A, Whittle H, Rowland-Jones S, and Cotten M
- Subjects
- Antiviral Restriction Factors, Carrier Proteins metabolism, Cohort Studies, Guinea-Bissau, HIV-2 genetics, HIV-2 physiology, Humans, Models, Molecular, Phylogeny, Polymorphism, Genetic, RNA, Viral genetics, Sequence Analysis, Protein, Tripartite Motif Proteins, Ubiquitin-Protein Ligases, Virus Replication, gag Gene Products, Human Immunodeficiency Virus metabolism, Capsid virology, HIV Infections virology, HIV-2 pathogenicity, Viral Load
- Abstract
HIV-2 causes AIDS similar to HIV-1, however a considerable proportion of HIV-2 infected patients show no disease and have low plasma virus load (VL). An analysis of HIV-2 capsid (p26) variation demonstrated that proline at p26 positions 119, 159 and 178 are more frequent in lower VL subjects while non-proline residues at all three sites are more frequent in subjects with high VL. In vitro replication levels of viruses bearing changes at the three sites suggested that these three residues influence virus replication by altering susceptibility to TRIM5alpha. These results provide new insights into HIV-2 pathogenesis., (Copyright (c) 2009 Elsevier Ltd. All rights reserved.)
- Published
- 2010
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