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Introduction: Staphylococcus aureus is responsible for causing a variety of human infections, which may range from minor skin diseases to life-threatening infections. It colonizes healthy individuals and causes severe infection in hospitalized patients. Staphylococcus aureus infections used to respond to ß-lactam and related group of antibiotics but the emergence of Methicillin-resistant S. aureus (MRSA) has posed a serious therapeutic challenge. The present study aimed to determine prevalence of Methicillin-resistant Staphylococcus aureus in Dhiraj General Hospital, Gujarat and to determine antibiotic sensitivity pattern of Methicillin resistant Staphylococcus aureus in various samples and to determine inducible clindamycin resistance strains out of Methicillin resistant Staphylococcus aureus at Dhiraj General Hospital. Materials and methods: The present study was conducted in Microbiology Department of SBKS MI and RC during January 2022 to December 2022. The study comprised of 114 coagulase-positive staphylococci (COPS), isolated from a total of 1470 clinical specimens (like pus, blood, urine, high vaginal swab, sputum, etc.) of patients admitted in Dhiraj General hospital attached to SBKS MI and RC, Hospital, Waghodia, Gujarat. All the isolates were identified by standard procedures. Antimicrobial susceptibility test was carried out on each bacterial isolate using the disc diffusion method on Muller Hinton agar (MHA). Data were entered and analyzed statistically. Results: During one year of study period, a total of 1470 positive culture samples were there. Out of that, 114 positive samples of Staphylococcus aureus were isolated. Out of total Staphylococcus aureus positive samples, 24 strains of Methicillin resistant Staphylococcus aureus (MRSA) were detected. Out of total MRSA, 10 inducible clindamycin resistant Staphylococcus aureus were detected. Conclusion: To conclude, we can say that Vancomycin and Teicoplanin is the drug of choice in MRSA patients. As MRSA is an alarming issue for the health system, one should always think about drug sensitivity test before starting treatment. [ABSTRACT FROM AUTHOR]