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Objective Earlier fieldwork in rural areas of Hainan Island, China, demonstrated that during the course of economic development increasing differences had emerged in lifestyles within communities. It is possible that these variations might have stratified residents into subpopulations with different health attributes. This study examined the association between C-reactive protein (CRP) concentration, a biomarker of future cardiovascular events, and personal lifestyle parameters and the degree of community-level economic development among rural communities. Methods A cross-sectional field survey was undertaken in 19 rural communities in Hainan. Convenience sampling was used to recruit 1,744 participants. Dried blood spot samples were collected to measure high-sensitivity CRP concentration. Sex-stratified multilevel regression analyses were conducted to identify factors associated with CRP concentration among the participants. Results While CRP concentration was negatively associated with being married and (more) education among men, for women CRP concentration was associated with the frequency of poultry consumption ( P = 0.014) and the experience of migratory work in the previous year ( P = 0.009). In addition, for females, living in communities with a greater degree of inequality, as indexed by the Gini coefficient, was also associated with increased CRP concentration ( P = 0.003). Conclusion Given that CRP concentration is a marker of future CVD risk, this study suggests that within these previously homogenous rural communities, economic development might have stratified people into population subgroups with a different CVD risk. Am. J. Hum. Biol. 28:186-196, 2016. © 2015 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Season of birth (SOB) has been investigated as one of the environmental factors that might epigenetically determine the physiology of individuals. This study investigated the role of SOB in the association between Quality of Life (QOL), a proxy of psychological stress status, and C-reactive protein (CRP) concentration (i.e., inflammatory status) among 1,085 adults (aged 20–57 years old) in Hainan Island, China. High sensitivity CRP concentration was measured in dried blood spot samples, while the abbreviated version of the World Health Organization’s QOL questionnaire was used to gather information on six QOL domains. Analysis stratified by three historically distinct age groups revealed a significant association between CRP concentration, SOB, QOL and an interaction between SOB and QOL among the youngest and oldest groups. In the oldest group, those born in the dry season had a higher CRP concentration with worse QOL whereas in the youngest group, there was a higher CRP concentration with better QOL. Annual per capita rice production, a proxy of population nutritional status in the year of birth, was found to predict CRP concentration only among the second oldest group. These findings suggest that the early environment might affect the immune response to psychological stress in adulthood and that its effect may differ by the time period in which people were born. [ABSTRACT FROM AUTHOR]

Objective Epstein-Barr virus (EBV) antibody titer has recently been used as a biomarker of psychological stress. This is the first study to investigate the association between EBV antibody titer and perceived quality of life (QOL) in Hainan Island, China. Methods Participants from two regions of Hainan Island, recruited into a larger study investigating the health impact of rapid economic development among rural residents, were stratified by age, sex, and region; 15 people were randomly selected from each of the 16 subgroups, to give a total sample size of 240. EBV antibody titer in dried blood spot samples was measured by enzyme-linked immunosorbent assay. The abbreviated version of the World Health Organization's Quality of Life questionnaire was used to gather information on six categories of QOL. Multiple linear regression analysis was used to examine the relationship between EBV antibody titer and QOL. Results After adjusting for the effects of age, sex, region and C-reactive protein concentration, EBV antibody titer was negatively associated with the physical ( P = 0.044) and psychological QOL domains ( P = 0.039). Conclusion This study suggests that among individuals living in an environment in the initial stages of economic development EBV antibody titer, a biomarker of psychological stress, is not only associated with the psychological aspects of QOL but is also linked to physical problems. Am. J. Hum. Biol. 26:51-55, 2014. © 2013 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Objective Little is known about inter-individual variation in psychological stress in modernizing rural populations in developing countries. The objective of this study was to investigate the association between Epstein-Barr virus (EBV) antibody titer, a biomarker of psychological stress, and lifestyle parameters in rural communities in Hainan Island, China. Methods EBV antibody titer was measured in dried blood spot (DBS) samples collected from 240 adults living in rural communities in Hainan Island. Measures of two major lifestyle changes in rural areas of Hainan Island, i.e., diet and commercial goods possession, were examined by using information on the weekly frequency of pork consumption and monthly mobile phone fees. Both parameters were standardized to create two composite scores: a total affluence index (TAI-the sum of these scores), and an investment tendency index (ITI-the difference between them). Least-squares regression analysis was used to investigate the association between EBV antibody titer and these lifestyle parameters. Results A positive association was found between the frequency f pork consumption and EBV antibody titer ( P = 0.040), whereas a negative association was found between mobile phone fees and EBV antibody titer ( P = 0.028). A negative association was also observed between ITI and EBV antibody titer ( P = 0.002) after adjusting for the effect of TAI. Conclusion Psychological stress among local residents was linked to the type of lifestyle changes they had experienced, where the adoption of a more market-oriented lifestyle, irrespective of current affluence, was associated with less psychological stress. Am. J. Hum. Biol. 26:36-42, 2014. © 2013 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]