1. Lingaoamide, a cyclic heptapeptide from a Chinese freshwater cyanobacterium Oscillatoria sp.
- Author
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Iwasaki, Arihiro, Kurisawa, Naoaki, Wang, Tingting, Li, Xiaohui, Luo, Haixi, Zhu, Chengcong, Patial, Gaurav, Yan, Xiaojun, He, Shan, Luzzatto-Knaan, Tal, Tian, Fuli, Naman, C. Benjamin, and Suenaga, Kiyotake
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MARINE natural products , *PYRICULARIA grisea , *BACILLUS pumilus , *FRESH water , *PADDY fields , *MICROCYSTIS - Abstract
[Display omitted] • Cyanobacteria were collected from flooded paddy farm fields in Hainan, China. • A new marine natural product, lingaoamide, was discovered and characterized. • Lingaoamide upregulates biogenesis of pro-pathogenic melanins in rice blast fungus. • Lingaoamide does not appear to modulate plant growth or immune response. Lingaoamide (1), a new cyclic heptapeptide natural product, was isolated from a freshwater Oscillatoria cyanobacterium. The producing organism was collected in Chinese water spinach paddy farm fields in Lingao County, Hainan, China. The structure of 1 was determined by conventional mass spectrometry, NMR spectroscopy, and chemical degradation studies. Lingaoamide concentration-dependently up-regulates the biogenesis of pro-pathogenic melanin pigments (melanogenesis) in the rice blast fungus, Magnaporthe grisea, when tested in vitro. This molecule also exhibits weak in vitro inhibition (MIC 32 μg/mL) of Gram-negative Pseudomonas aeruginosa and Gram-positive Bacillus pumilus , and does not appear to impact plant growth or immune response in vivo using the model organism, Arabidopsis thaliana. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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