1. Rubella antibody persistence after immunization. Sixteen-year follow-up in the Hawaiian Islands.
- Author
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Chu SY, Bernier RH, Stewart JA, Herrmann KL, Greenspan JR, Henderson AK, and Liang AP
- Subjects
- Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Follow-Up Studies, Hawaii, Humans, Random Allocation, Time Factors, Antibodies, Viral analysis, Rubella Vaccine immunology, Rubella virus immunology
- Abstract
A comparative field trial of three rubella virus vaccines (Cendehill, HPV-77 DE-5, and HPV-77 DK-12) was initiated in 1969 on the islands of Kauai and Hawaii in the state of Hawaii. In 1985, follow-up was reinitiated to assess the long-term durability of vaccine-induced immunity. Enzyme-linked immunosorbent assays of serum specimens from 1290 participants demonstrated seropositive rates of 92.4% and 96.4% at screening levels of 10 (protective level) and 7 (lowest detectable level) IU/mL, respectively. The seropositive rates were not related to reinfection or reimmunizations. These findings indicate that vaccine-induced rubella antibodies are detectable in almost all persons up to 16 years after successful vaccination.
- Published
- 1988
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