1. Serum leptin and total dietary energy intake: the INTERLIPID Study.
- Author
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Nakamura, Yasuyuki, Ueshima, Hirotsugu, Okuda, Nagako, Murakami, Yoshitaka, Miura, Katsuyuki, Kita, Yoshikuni, Okamura, Tomonori, Okayama, Akira, Turin, Tanvir, Choudhry, Sohel, Rodriguez, Beatriz, David Curb, J., and Stamler, Jeremiah
- Subjects
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ANTHROPOMETRY , *CHI-squared test , *STATISTICAL correlation , *INGESTION , *OBESITY , *RESEARCH funding , *LEPTIN , *MULTIPLE regression analysis , *BODY mass index , *DATA analysis software , *DESCRIPTIVE statistics - Abstract
Purpose: It has been hypothesized that leptin-induced appetite suppression is impaired in obese individuals, but little human evidence is available documenting this. We investigated relations between serum leptin and total energy intake using INTERLIPID/INTERMAP data on Japanese-Americans in Hawaii and Japanese in Japan. Methods: Serum leptin and nutrient intakes were examined by standardized methods in men and women aged 40-59 years from two population samples, one Japanese-American in Hawaii (88 men, 94 women), the other Japanese in central Japan (123 men, 111 women). Multiple linear regression analyses stratified by BMI category (<25 kg/m, 25-29.9 kg/m, and ≥30 kg/m) with adjustment for possible confounders were used to examine the relation between log-leptin and total dietary energy intake. Results: In multivariate regression analyses, in those with BMI < 25 kg/m and in those with BMI between 25 and 29.9 kg/m, log-leptin was not significantly related to total dietary energy intake; in those with BMI ≥ 30 kg/m, it was significantly inversely related to total dietary energy intake ( P = 0.029), independent of body weight and physical activity. Physical activity score was significantly positively related to total dietary energy intake only in participants with BMI < 25 kg/m ( P < 0.001). Conclusion: Leptin was significantly inversely associated with dietary energy intake in obese persons, but not in overweight and normal-weight persons. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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