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The present work aimed to study the effects of temperature changes and concrete creep on I-shaped steel–concrete composite continuous girder bridges during construction and operation processes. This study combined structural health monitoring data, an ANSYS finite element simulation, and the age-adjusted effective modulus method to obtain the variation laws of temperature and internal force in composite girders. Moreover, a temperature gradient model was proposed that is suitable for bridges in Hebei, China. In addition, a concrete creep experiment under unidirectional axial compression was performed using concrete specimens prepared from the concrete batch used to create the composite girder. The long-term evolution laws of the deflection and internal force of the composite girder were obtained by predicting the concrete creep effect. The measured data showed that the temperature variation trends of the steel beam and concrete slab were characterized by a sinusoidal curve without a temperature lag. The heating rate of the concrete slab was higher than the cooling rate. The prediction results showed that the internal force changes in the composite girder were characterized by three stages. The stress changes in the composite girder during the first 10 days were significant and the stress charge rate of the concrete slab, the steel girder and the shear stud can reach 5%–28%. The stress change rate decreased continuously during 10–90 days. The stress changed slowly and smoothly after 90 days. This research can provide feedback and reference for structural health monitoring and service safety control of similar I-shaped steel–concrete composite bridges. [ABSTRACT FROM AUTHOR]