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The Shishapangma region, situated in the middle of the Himalayas, is rich in glacial lakes and glaciers. Hence, glacial lake outburst floods (GLOFs) have become a top priority because of the severe threat posed by GLOFs to the downstream settlements. This study presents a comprehensive analysis of GLOF hazards using multi-source remote sensing datasets and designs a flood model considering the different breaching depths and release volumes for the Galong Co region. Based on high-resolution optical images, we derived the expanding lake area and volume of glacial lakes. We monitored deformation velocity and long-term deformation time series around the lake dam with Small BAseline Subset Interferometric Synthetic Aperture Radar (SBAS-InSAR). The glacier thinning trend was obtained from the difference in the Digital Elevation Model (DEM). We identified potential avalanche sources by combining topographic slope and measurable deformation. We then carried out flood modeling under three different scenarios using the hydrodynamic model HEC-RAS for Galong Co, which is formed upstream of Nyalam. The results show that the Nyalam region is exposed to high-intensity GLOFs in all scenarios. The larger breaching depth and release volumes caused a greater flow depth and peak discharge. Overall, the multiple remote sensing approaches can be applied to other glacial lakes, and the modeling can be used as a basis for GLOF mitigation. [ABSTRACT FROM AUTHOR]