1. Neutrophils, Nitric Oxide, and Microvascular Permeability in Severe Sepsis.
- Author
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Dhillon, Samjot S., Mahadevan, Karthik, Bandi, Venkata, Zheng, Zhilan, Smith, C. Wayne, and Rumbaut, Rolando E.
- Subjects
BLOOD vessel permeability ,NEUTROPHIL immunology ,COMPLEMENT activation ,SEPSIS ,NITRIC oxide ,INTENSIVE care units ,HOSPITALS - Abstract
This article cites a study determining whether septic patients have increased capillary filtration coefficient and whether the magnitude of filtration coefficient correlates with indexes of nitric oxide activity and neutrophil activation. Both septic and nonseptic control subjects were recruited prospectively from the 25-bed medical intensive care unit (ICU)/coronary care unit of the Ben Taub General Hospital from August 2002 through June 2003. Septic subjects were recruited based on the American College of Chest Physicians/Society of Critical Care Medicine consensus criteria of 1992 for severe sepsis. It was noticed that ICU patients with severe sepsis had increased filtration coefficient. The magnitude of hyperpermeability did not correlate with nitric oxide activity or neutrophil activation.
- Published
- 2005
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