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OBJECTIVE Orthohantaviruses (genus Orthohantavirus, family Hantaviridae of order Bunyavirales) are rodent-borne viruses causing 2 human diseases: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS), which are mainly prevalent in Eurasia and the Americas, respectively. We initiated this study to investigate and analyze the Orthohantaviruses infection in rodent reservoirs and humans in the Hubei Province of China from 1984 to 2010. SAMPLE The study included 10,314 mouse and 43,753 human serum samples. PROCEDURES In this study, we analyzed the incidence of Orthohantavirus infection in humans and observed changes in rodent reservoirs in Hubei Province. RESULTS The results indicated that although the incidence of HFRS declined from the 1990s, the human inapparent infection did not decrease dramatically. Although elements of the disease ecology have changed over the study period, Apodemus agrarius and Rattus norvegicus remain the major species and a constituent ratio of Rattus norvegicus increased. Rodent population density fluctuated between 16.65% and 2.14%, and decreased quinquennially, showing an obvious downward trend in recent years. The average orthohantaviruses-carrying rate was 6.36%, of which the lowest rate was 2.92% from 2006 to 2010. The analysis of rodent species composition showed that Rattus norvegicus and Apodemus agrarius were the dominant species over time (68.6% [1984 to 1987] and 90.4% [2000 to 2011]), while the composition and variety of other species decreased. The density of rodents was closely related to the incidence of HFRS (r = 0.910, P = .032). CLINICAL RELEVANCE Our long-term investigation demonstrated that the occurrence of HFRS is closely related to rodent demographic patterns. Therefore, rodent monitoring and rodent control measures for prevention against HFRS in Hubei are warranted. [ABSTRACT FROM AUTHOR]

Brucellosis is a zoonotic animal disease causing a serious obstacle to public health, social and economic progress, food security and food safety. The present study was to investigate the prevalence of Brucella infection in goats in Hubei province, China. A total 2007serum samples were obtained from 6 counties in Hubei province in 2014 and 2015 and were tested for antibodies to Brucella by serum agglutination test. The results showed that the seroprevalence of Brucella in goats was 0.25% (95% CI= 0.1-0.6). In different genders, the prevalence were 0.21% (95% CI= 0-0.8) and 0.28% (95% CI= 0.1-0.8) in male and female goats, respectively. In different seasons, the prevalence ranged from 0 to 0.38% with the distribution of that 0 (95 CI: 0.0, 0.1) in spring; 0.35% (95 CI: 0.1, 0.3) in summer; 0.38% (95 CI: 0.1, 0.6) in autumn and 0 (95 CI: 0.0, 1.3) in winter, respectively. The present study herein indicated the existence of Brucella infection in goats in Hubei province in serology for the first time. [ABSTRACT FROM AUTHOR]