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To investigate the geodynamic processes of Mesozoic large-scale mineralization in South China, we deployed a 350-km-long, wide-angle seismic reflection/refraction sounding profile between Yingshan in Hubei and Changshan in Zhejiang. This profile traverses the Cu-Au metallogenic belt in the middle and lower reaches of the Yangtze River (YMB), the Jiangnan W-polymetal metallogenic belt (JNMB), and the Qinhang Cu-polymetal metallogenic belt (QHMB). Our imaging results reveal various interesting velocity features along the profile. (1) The velocity structure is characterized by vertical layering and horizontal blocking; (2) the YMB is marked by high velocity and high Vp/Vs ratios in general with a significantly uplifted Moho interface and a thin crust of ∼31 km, and the lower crust contains high-velocity anomalies and has the characteristics of a crust-mantle transition zone; (3) the JNMB is bounded by the Jiangnan fault and Jingdezhen-Huangshan fault and has low-velocity anomalies and low Vp/Vs ratios; and (4) the QHMB is characterized by high-velocity anomalies and high Vp/Vs ratios. The high-velocity anomalies in the YMB and QHMB represent relatively Cu-Au-rich mafic juvenile lower crust. The formation of this kind of crust is considered to be related to mantle-derived magma underplating or residues of Neoproterozoic oceanic crustal materials, and it also provided sources for large-scale Cu-Au mineralization in the Mesozoic. The JNMB has features similar to those of ancient crusts enriched in W-Sn, the partial melting of which played a leading role in the formation of the superlarge W deposits in this belt. Considering these results and other regional geological data, we propose that a large-scale oblique upwelling of the asthenosphere along the collisional belt of the Yangtze and Cathaysia blocks during the Mesozoic was the deep driving mechanism for the explosive mineralization of Cu, Au, and W in northeastern South China. The boundaries of the blocks or terrains and discontinuities of the lithosphere were the main channels for deep heat and magmas and therefore controlled the spatial distribution of the metallogenic belt. [ABSTRACT FROM AUTHOR]