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A recent study conducted in Hunan, People's Republic of China, focused on improving the mechanical and osteogenic induction properties of bone scaffolds. The researchers encapsulated graphene oxide (GO) with polydopamine (PDA) and loaded strontium (Sr) onto GO through the chelation of PDA. The modified GO was added to the bone scaffold, resulting in significant improvements in tensile and compressive strengths. The presence of Sr in the scaffold also promoted the proliferation and differentiation of osteoblasts, enhancing its osteogenic induction properties. This research has been peer-reviewed and provides valuable insights into the development of more effective bone scaffolds. [Extracted from the article]

Researchers at Xiangya Hospital 3 in Hunan, China have developed a new type of bone scaffold that combines photothermal therapy (PTT) and bone regeneration induction for the treatment of osteosarcoma. The scaffold, which is loaded with single-atom Cu nanozymes, exhibits exceptional photothermal conversion properties and mimics peroxidase and glutathione oxidase activities. This leads to lipid peroxidation and reactive oxygen species upregulation, ultimately causing ferroptosis and inhibiting tumor growth. The scaffold also promotes bone regeneration through the release of bioactive ions. The study concludes that this novel composite bone scaffold achieves ferroptosis-synergized mild photothermal antitumor effects and accelerated bone regeneration in osteosarcoma treatment. [Extracted from the article]

According to the news reporters, the research concluded: "Besides, in vivo skull defect repair experiments showed that the scaffolds possessed good ability to promote bone differentiation and new bone regeneration." Keywords: Hunan; People's Republic of China; Asia; Bioengineering; Biomedical Engineering; Biomedicine; Biotechnology; Bone Research; Bone Scaffolds; Health and Medicine; Light Metals; Magnesium; Tissue Engineering EN Hunan People's Republic of China Asia Bioengineering Biomedical Engineering Biomedicine Biotechnology Bone Research Bone Scaffolds Health and Medicine Light Metals Magnesium Tissue Engineering 456 456 1 07/03/23 20230706 NES 230706 2023 JUL 6 (NewsRx) -- By a News Reporter-Staff News Editor at Blood Weekly -- Investigators discuss new findings in Biomedical Engineering - Bone Scaffolds. [Extracted from the article]