1. Tumor necrosis factor alpha –C850T polymorphism is significantly associated with endometriosis in Asian Indian women
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Vijaya Lakshmi, Kodati, Shetty, Preetha, Vottam, Kiran, Govindhan, Sujatha, Ahmad, Shaik Noor, Hasan, Qurratulain, and Lakshmi, Kodati Vijaya
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TUMOR necrosis factors , *GENETIC polymorphisms , *ENDOMETRIOSIS , *NATIVE American women , *MEDICINE case studies , *ULTRASONIC imaging , *HEALTH outcome assessment , *DISEASES , *PATIENTS - Abstract
Objective: To establish the association of tumor necrosis factor alpha (TNFA) promoter C850T polymorphism in Asian Indian women with endometriosis.Design: Case control study, from multiple gynecological centers from Hyderabad, a cosmopolitan city in southern India. The study included 245 women who comprised 110 surgically confirmed cases of endometriosis, 50 ultrasonographically confirmed cases of fibroid tumors, and 85 healthy female volunteers.Setting: Academic hospital.Patient(s): The cases were 245 women, 160 patients and 85 controls.Intervention(s): None.Main Outcome Measure(s): Tumor necrosis factor alpha -C850T polymorphism may be used as a molecular marker for endometriosis in our population.Result(s): In this study we have demonstrated an association between TNFA -C850T polymorphism and endometriosis. The T allele is significantly associated with endometriosis when compared to women with fibroids as well as healthy controls. Our data imply that the T allele is associated with endometriosis (OR = 1.9594: 95% CI, 1.3833-2.7753; in our population. The TT genotype increases the risk of endometriosis by fourfold (4.5542: 95% CI, 2.0388-10.1701.Conclusion(s): This study suggests that -C850T TNFA gene polymorphism could be used as a relevant molecular marker to identify women with risk of developing endometriosis in our population. [ABSTRACT FROM AUTHOR]- Published
- 2010
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