1. Correlation of Haematological Scoring System with C-Reactive Protein and Blood Culture in the Diagnosis and Prognosis of Neonatal Sepsis in A Tertiary Care Hospital, Hyderabad.
- Author
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Manvitha, Goshibatla, Geetha, Kayla, Vani Padmaja, G. J., and Devi M., Anjani
- Subjects
NEONATAL sepsis ,BLOOD proteins ,C-reactive protein ,HOSPITAL care ,TERTIARY care ,PROGNOSIS - Abstract
Background: In this study, we wanted to evaluate the diagnostic utility of the Haematological Scoring System of Rodwell et al in correlation with C-Reactive protein and blood culture and assessing its prognostic value, estimate the Haematological Scoring System of Rodwell et al, compare its correlation with C- reactive protein and blood culture in Neonatal Sepsis, and assess its prognostic value in reflecting the patient's outcome. Methods: This was a hospital based cross-sectional study conducted among 300 blood samples from clinically suspected cases of neonatal sepsis in the Department of Pathology at Niloufer Hospital, a Tertiary Care Centre in Hyderabad for a period of 2 years, from 2020 to 2022 after obtaining clearance from institutional ethics committee and written informed consent from the study participants. Results: The sensitivity and specificity of deranged Total Leucocyte count were 58.92% and 84.35% respectively. The sensitivity and specificity of deranged Absolute Neutrophil Count were 86.49% and 46.09% respectively. The sensitivity and specificity of increased Immature Neutrophil Count were 79.46% and 80.87% respectively. The sensitivity and specificity of increased I:T ratio were 80.54% and 83.48% respectively. The sensitivity and specificity of increased I:M ratio were 63.24% and 96.52% respectively. The sensitivity and specificity of Degenerative neutrophil changes were 31.89% and 97.39% respectively. The sensitivity and specificity of reduced platelet count were 65.95% and 55.65% respectively. When correlated with blood culture, * The sensitivity and specificity of blood samples with HSS≥3 were 96.55% and 59.23% respectively. * The sensitivity and specificity of blood samples with HSS≥4 were 92.24% and 71.73% respectively. * The sensitivity and specificity of blood samples with HSS≥5 were 74.13% and 82.6% respectively. When correlated with CRP, * The sensitivity and specificity of blood samples with HSS>3 were 89.18% and 80.86% respectively. * The sensitivity and specificity of blood samples with HSS>4 were 77.3 and 86.08 respectively. * The sensitivity and specificity of blood samples with HSS>5 were 62.16 and 97.39 respectively. As the HSS scores increased, the specificity increased with a reduction of sensitivity. Thus overall, an HSS score of 4 and above was considered the most reliable indicator for the early diagnosis of Neonatal Sepsis. There is prolonged duration of hospitalisation with increase in HSS, ranging from 1-3 days in score 0 to 11-32 days in score 7. The scoring system has come down to <3 with appropriate response to treatment. Conclusion: HSS not only helps in diagnosis but also helps in predicting the severity and outcome of neonatal sepsis, reflected by prolonged duration of hospitalisation of the patients and reduction in the score with appropriate response to therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2023