1. Sleep duration and 24-hour ambulatory blood pressure in adults not on antihypertensive medications.
- Author
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Shulman, Rachel, Cohen, Debbie L., Grandner, Michael A., Gislason, Thorarinn, Pack, Allan I., Kuna, Samuel T., Townsend, Raymond R., and Cohen, Jordana B.
- Subjects
CARDIOVASCULAR disease related mortality ,HYPERTENSION epidemiology ,AMBULATORY blood pressure monitoring ,BEHAVIOR ,BLOOD pressure ,CARDIOVASCULAR diseases ,CIRCADIAN rhythms ,HYPERTENSION ,RESEARCH funding ,SLEEP apnea syndromes ,SLEEP deprivation ,DISEASE prevalence ,CROSS-sectional method ,EARLY diagnosis ,DISEASE complications - Abstract
Short sleep duration has been widely linked to increased cardiovascular morbidity and mortality. We performed a post hoc analysis of 24-hour ambulatory blood pressure monitoring (ABPM) in the Lifestyle Modification in Blood Pressure Lowering Study (LIMBS) and Penn Icelandic Sleep Apnea (PISA) Study. The 24-hour mean systolic blood pressure (BP) was 12.7 mm Hg higher in LIMBS (P < 0.001; n = 66) and 4.7 mm Hg higher in PISA (P = 0.005; n = 153) among participants with shorter sleep duration (less than 7 hours) compared to those with longer sleep duration (at least 7 hours). In multivariable adjusted models, shorter sleep duration was strongly associated with higher systolic BP on 24-hour ABPM, independent of nocturnal BP and in-office BP. There was no effect modification by obstructive sleep apnea. Adults with shorter sleep duration may benefit from screening with 24-hour ABPM to promote earlier detection of hypertension and potentially mitigate their increased risk for future cardiovascular disease. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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