1. Saccharonol B, a new cytotoxic methylated isocoumarin from Saccharomonospora azurea.
- Author
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Singh, Baljinder, Parshad, Rajinder, Khajuria, R.K., Guru, Santosh K., Pathania, Anup S., Sharma, Rashmi, Chib, Reena, Aravinda, Subrayashastry, Gupta, Vivek K., Khan, Inshad A., Bhushan, Shashi, Bharate, Sandip B., and Vishwakarma, Ram A.
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SWEETENERS , *GRAM-positive bacteria , *ANTI-infective agents , *CELL-mediated cytotoxicity , *ISOCOUMARINS - Abstract
Abstract: From an antimicrobial gram-positive actinomycete strain of Saccharomonospora azurea (MTCC11714) isolated from high altitude soil of Kargil (J&K, India), a new isocoumarin saccharonol B (2) along with two known compounds viz. saccharonol A (1) and piericidin A3 (3) was isolated and characterized. The structure of the new compound was established based on extensive 2D-NMR data. Saccharonol B (2) exhibited mild antimicrobial activity against a standard panel of microorganisms Staphylococcus aureus ATCC 29213, Candida albicans ATCC 90028, and Aspergillus fumigatus MTCC 1811 with MIC values in the range of 128–248μg/mL. Saccharonol B (2) and piericidin A3 (3) showed selective cytotoxic activity against human pancreatic carcinoma cell line (MIAPaCa-2) with IC50 values of 9 and 8μM, respectively. Mechanistic studies indicated that saccharonol B (2) arrests S-phase of the cell cycle and causes dose-dependent loss of mitochondrial potential in MIAPaCa-2 cells. [Copyright &y& Elsevier]
- Published
- 2013
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