1. Lack of association of a common polymorphism in the 3' -UTR of interleukin 8 with non small cell lung cancer in Kashmir.
- Author
-
Bhat IA, Pandith AA, Bhat BA, Naykoo NA, Qasim I, Rasool R, Aziz SA, and Shah ZA
- Subjects
- Adenocarcinoma genetics, Adenocarcinoma pathology, Adenocarcinoma, Bronchiolo-Alveolar genetics, Adenocarcinoma, Bronchiolo-Alveolar pathology, Carcinoma, Large Cell genetics, Carcinoma, Large Cell pathology, Carcinoma, Non-Small-Cell Lung pathology, Carcinoma, Squamous Cell genetics, Carcinoma, Squamous Cell pathology, Case-Control Studies, Female, Follow-Up Studies, Genotype, Humans, India, Lung Neoplasms pathology, Male, Middle Aged, Neoplasm Staging, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Prognosis, 3' Untranslated Regions genetics, Carcinoma, Non-Small-Cell Lung genetics, Interleukin-8 genetics, Lung Neoplasms genetics, Polymorphism, Genetic genetics
- Abstract
Background: Chronic inflammation is considered as an important factor in the pathogenesis of lung cancer. The presence of inflammatory cells and higher levels of pro-inflammatory cytokines in the tumor microenvironment and their surrounding tissues is gaining much importance in research., Materials and Methods: One hundred ninety NSCLC cases and 200 age, smoking and sex matched controls were evaluated for association of IL-8 -251 (rs4073) and IL-8 -845 (rs2227532) in our population. Restriction fragment length polymorphism (RFLP) was used followed by direct sequencing for the detection of SNPs., Results: The IL-8 -845 polymorphism was not found in our population. No significant association was observed between the IL-8 -251 AT genotypes and IL-8 -25 AA genotypes and NSCLC (p=0.05) in our population. The IL-8 -251 A allele was also non-significant (p=0.05) in NSCLC patients., Conclusions: In conclusion, this report reveals lack of association between IL-8 - 251 A/T polymorphism and NSCLC in our Kashmir Valley population.
- Published
- 2013
- Full Text
- View/download PDF