1. Impact of age of onset of illness on clinical phenotype in OCD.
- Author
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Narayanaswamy JC, Viswanath B, Veshnal Cherian A, Bada Math S, Kandavel T, and Janardhan Reddy YC
- Subjects
- Adolescent, Adult, Age Factors, Age of Onset, Aged, Compulsive Behavior complications, Compulsive Behavior diagnosis, Female, Humans, India, Male, Middle Aged, Obsessive Behavior complications, Obsessive Behavior diagnosis, Obsessive-Compulsive Disorder complications, Obsessive-Compulsive Disorder diagnosis, Phenotype, Psychiatric Status Rating Scales, Sex Factors, Tic Disorders complications, Tic Disorders diagnosis, Compulsive Behavior epidemiology, Obsessive Behavior epidemiology, Obsessive-Compulsive Disorder epidemiology, Tic Disorders epidemiology
- Abstract
Background: This study aims to examine the demographic, clinical and comorbid patterns in a large sample of adult OCD subjects at a specialty OCD clinic in India., Methods: Consecutive patients (n=545) who consulted a specialty OCD Clinic over 5 years at a large psychiatric hospital in India were evaluated with the Mini International Neuropsychiatric Interview, the Yale-Brown Obsessive-Compulsive Scale, and the Clinical Global Impression scale., Results: Earlier age onset of OCD (years) was characterized by male preponderance (19.61±7.98 vs. 25.19±10.39, U=23453.5, p=<0.001), positive family history of OCD (19.60±10.02 vs. 22.27±9.20, U=16590.5, p<0.001) and presence of tic disorder (16.28±8.21 vs. 22.01±9.38, OR=0.86, p=0.001). In addition, early age of onset was associated with presence of sexual obsessions (18.92±7.49 vs. 22.88±9.82, OR=0.96, p=0.02), hoarding (19.61±9.32 vs. 22.21±9.36, OR=0.95, p=0.009), repeating rituals (19.76±8.37 vs. 23.29±9.84, OR=0.95, p=0.006) and need to touch compulsions (16.40±7.19 vs. 22.36±9.43, OR=0.89, p<0.001)., Conclusions: Our findings from a large sample not only confirm that early onset OCD could be a valid and distinct subtype of OCD but also support the cross-cultural similarity of early onset phenotype., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2012
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