1. Is central obesity, hyperinsulinemia and dyslipidemia associated with high-grade prostate cancer? A descriptive cross-sectional study.
- Author
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Prabhat, Pawni, Tewari, Reshu, Natu, S. M., Dalela, D., Goel, A., Tandon, P., Goel, M. M., and Singh, K.
- Subjects
ANALYSIS of variance ,COMPUTER software ,HIGH density lipoproteins ,HYPERLIPIDEMIA ,INSULIN ,LOW density lipoproteins ,RESEARCH methodology ,METABOLIC disorders ,OBESITY ,PROSTATE tumors ,TESTOSTERONE ,TUMOR classification ,U-statistics ,PROSTATE-specific antigen ,DATA analysis ,CROSS-sectional method ,SEVERITY of illness index ,WAIST-hip ratio ,DISEASE complications - Abstract
Aim: The association of central obesity, hyperinsulinemia, and dyslipidemia with higher grade advanced prostate cancer as determined by Gleason grading is not well understood. We evaluated the effect of central obesity waist hip ratio (WHR ≥ 0.9) and biochemical parameters associated with central obesity on Gleason grading in North Indian patients of prostate cancer presenting at advanced stages. Materials and Methods: A cross-sectional study was conducted among 50 nondiabetic patients having clinical stages III and IV prostate cancer. Gleason grading on core biopsy samples by histopathology was done and patients were divided in two groups--group1, Gleason score ≥8; group 2, Gleason score <8. WHR along with serum levels of prostate-speciic antigen (PSA), testosterone, insulin, and lipid proile was done in each patient. Results: The two groups are similar in Age (67.54 years); range (50-80 years). Group 1 men had statistically higher mean WHR (0.96 vs 0.90; P ≤ 0.001), higher mean triglyceride level (201.34 vs 150.52 mg/dL; P=0.0006), higher mean very low- density lipoprotein (VLDL) (40.27 vs 30.10 mg/dL; P=0.0006), higher mean insulin (19.49 vs 15.04 µIU/mL; P=0.0024), and lower mean high-density lipoprotein (HDL) levels (32.39 vs 36.82 mg/dL; P = 0.034) than men in group 2. Serum levels of cholesterol, LDL, and testosterone did not show statistically signiicant differences between the two groups. Conclusions: This pilot study involving small number of patients indicates that central obesity, dyslipidemia, and hyperinsulinemia could be associated with high-grade prostate cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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