1. Simultaneous Infection with Enterobacteriaceae and Pseudomonas aeruginosa Harboring Multiple Carbapenemases in a Returning Traveler Colonized with Candida auris.
- Author
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Khan A, Shropshire WC, Hanson B, Dinh AQ, Wanger A, Ostrosky-Zeichner L, Arias CA, and Miller WR
- Subjects
- Candida genetics, Candidiasis microbiology, Critical Illness, Enterobacteriaceae enzymology, Enterobacteriaceae genetics, Enterobacteriaceae Infections microbiology, Escherichia coli enzymology, Escherichia coli genetics, Escherichia coli isolation & purification, Escherichia coli Proteins genetics, Female, Humans, India, Klebsiella pneumoniae enzymology, Klebsiella pneumoniae genetics, Klebsiella pneumoniae isolation & purification, Middle Aged, Pseudomonas aeruginosa enzymology, Pseudomonas aeruginosa genetics, Anti-Bacterial Agents therapeutic use, Bacterial Proteins genetics, Candida isolation & purification, Candidiasis diagnosis, Enterobacteriaceae isolation & purification, Enterobacteriaceae Infections diagnosis, Pseudomonas aeruginosa isolation & purification, beta-Lactamases genetics
- Abstract
We report our clinical experience treating a critically ill patient with polymicrobial infections due to multidrug-resistant Escherichia coli , Klebsiella pneumoniae , and Pseudomonas aeruginosa in a 56-year-old woman who received health care in India and was also colonized by Candida auris A precision medicine approach using whole-genome sequencing revealed a multiplicity of mobile elements associated with NDM-1, NDM-5, and OXA-181 and, supplemented with susceptibility testing, guided the selection of rational antimicrobial therapy., (Copyright © 2020 American Society for Microbiology.)
- Published
- 2020
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