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Objectives: To evaluate the hysterosalpingographic findings from infertile women who were subsequently diagnosed with genital tuberculosis. Methods: A retrospective study of 70 infertile women who underwent hysterosalpingography to investigate infertility and were subsequently diagnosed with genital tuberculosis. Results: The mean age of the women was 27.3 years and the mean duration of infertility was 6.1 years. A total of 57 (81.4%) women had primary infertility while 13 had secondary infertility. Diagnosis of genital tuberculosis was made by polymerase chain reaction (54.3%), tuberculous granuloma on biopsy (22.8%), acid-fast bacilli culture (2.8%), and at laparoscopy or hysteroscopy (20%). Hysterosalpingographic findings were a normal uterine cavity observed in 57.1% of women, an irregular cavity in 18.5%, a shrunken cavity in 2.8%, and an irregular filling defect in 18.5%. Synechiae were observed in 17.1% of women. Conclusion: Genital tuberculosis is a common cause of infertility in India, causing significant uterine and tubal pathologies. [ABSTRACT FROM AUTHOR]

Deletion in chemokine receptor CCR5 gene is reported to prevent development of tubal pathology among Dutch Caucasian C. trachomatisinfected women. Hence, a pilot study was undertaken, to evaluate the involvement of CCR5 gene in tubal pathology among Indian women with or without Chlamydia infection. Three hundred women with or without Chlamydia infection and with differentreproductive manifestations were screened for CCR5 gene using a standardized PCR. Only 6 C. trachomatis infected women without tubal block had heterozygous deletion for this gene. The rest had wild type CCR5 gene, that includes fertile women infected and non infected; infertile women infected and non infected with and without tubal block as well as infected women with history of recurrent spontaneous abortions. The study indicates no role of heterozygous CCR5 D32 gene deletion in prevention of tubal pathology in Chlamydiainfected Indian women. Only 2% heterozygous deletion in CCR5 gene is observed in the studied population. [ABSTRACT FROM AUTHOR]

Introduction Although there is no data about the incidence of Primary fallopian tube carcinoma in India but in the United States the incidence is 0.41 per 100, 000 population with less than 2000 cases reported all over the world. It is said that Primary fallopian tube carcinoma (PFTC) is very difficult to diagnose preoperatively, so while treating a case of adnexal mass, PFTC should be kept in mind. Case Report Mrs SB, a 57 yrs postmenopausal lady, presented with a history of lower abdominal pain and abnormal discharge per vaginum for 6 weeks. On clinical examination she had mild pallor, Per abdominal examination revealed tenderness on the left illiac fossa, Per vaginally cervix normal, uterus deviated towards the right side with a left adnexal mass with restricted mobility, it was tender on examination. MRI examination revealed a mixed echogenic mass on the left adnexae with normal uterus. PAP smear was normal and S CA125 was 354 U/ml. Patient was taken up for exploratory laparotomy, intraoperatively uterus was normal looking with normal right sided ovary and tube. On the left side ovary was normal however the left fallopian tube was enlarged and firm in consistency with open fimbrial end. Omental nodule was detected on inspection. She had undergone Total abdominal hysterectomy along with B/L salpingooporectomy, omentectomy plus nodal dissection. The postoperative period was uneventful and she was discharged on 5th post operative day. Her final HPE revealed Primary fallopian tube carcinoma (moderately diffentiated papillary adenocarcinoma) with omental metastasis, rest of the specimen was negative for malignancy. She was taken up for adjuvant chemotherapy and she completed six cycles of Paclitaxel plus Carboplatin. At present she is on regular followup for the last six plus years without any evidence of disease. Conclusion : In spite of advanced stage, in our case we had a good prognosis propably due to the absence of lymph nodal metastasis which is one of the important poor prognostic criteria in PFTC also a complete surgical debulking along with proper adjuvant chemotherapy is the key factor in the management of PFTC. [ABSTRACT FROM AUTHOR]