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An Attitude control system for a satellite in low earth orbit is designed in this project. As a reference, CARTOSAT-2 is selected to design the AOCS. CARTOSAT-2 is located in LEO so it suits the needs of the projects. It is mainly used for mapping of urban, rural areas and wetlands in India. To design a basic AOCS, a DC motor based model is considered. Transfer functions of DC motor and satellite dynamics model are calculated using Laplace transformation. Stability of the system is checked by plotting poles and zeroes of the systems. PID controller is used to improve the overall stability of the system by decreasing the errors in the output of the system. The systems are subjected to sine and step inputs and responses are plotted in the form of graphs. The plots are studied using SciLab as the tool to design the block diagram and the control system for the AOCS. Scilab along with FlightGear is used to visualize the response of the system. [ABSTRACT FROM AUTHOR]

Background: Glaucoma is the largest cause of irreversible blindness affecting more than 60 million people globally. The disease is defined as a gradual loss of peripheral vision due to death of Retinal Ganglion Cells (RGC). The RGC death is largely influenced by the rate of aqueous humor production by ciliary processes and its passage through the trabecular meshwork (TM) in the anterior part of the eye. Primary open angle glaucoma (POAG), the most common subtype, is a genetically complex disease. Multiple genes and many loci have been reported to be involved in POAG but taken together they explain less than 10 % of the patients from a genetic perspective warranting more studies in different world populations. The purpose of this study was to perform genome-wide search for common variants associated with POAG in an east-Indian population., Methods: The study recruited 746 POAG cases and 697 controls distributed into discovery and validation cohorts. In the discovery phase, genome-wide genotype data was generated on Illumina Infinium 660 W-Quad platform and the significant SNPs were genotyped using Illumina GGGT assay in the second phase. Logistic regression was used to test association in the discovery phase to adjust for population sub-structure and chi-square test was used for association analysis in validation phase. Publicly available expression dataset for trabecular meshwork was used to check for expression of the candidate gene under cyclic mechanical stress. Western blot and immunofluorescence experiments were performed in human TM cells and murine eye, respectively to check for expression of the candidate gene., Results: Meta-analysis of discovery and validation phase data revealed the association of rs7916852 in MPP7 gene (p = 5.7x10(-7)) with POAG. We have shown abundant expression of MPP7 in the HTM cells. Expression analysis shows that upon cyclic mechanical stress MPP7 was significantly down-regulated in HTM (Fold change: 2.6; p = 0.018). MPP7 protein expression was also found to be enriched in the ciliary processes of the murine eye., Conclusion: Using a genome-wide approach we have identified MPP7 as a novel candidate gene for POAG with evidence of its expression in relevant ocular tissues and dysregulation under mechanical stress possibly mimicking the disease scenario.