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The simulation results of CMIP5 (Coupled Model Inter-comparison Project phase 5) multi-model ensemble in the Indus River Basin (IRB) are compared with the CRU (Climatic Research Unit) and APHRODITE (Asian Precipitation-Highly-Resolved Observational Data Integration Towards Evaluation) datasets. The systematic bias between simulations and observations is corrected by applying the equidistant Cumulative Distribution Functions matching method (EDCDFm) and high-resolution simulations are statistically downscaled. Then precipitation and temperature are projected for the IRB for the mid-21st century (2046–2065) and late 21st century (2081–2100). The results show that the CMIP5 ensemble captures the dominant features of annual and monthly mean temperature and precipitation in the IRB. Based on the downscaling results, it is projected that the annual mean temperature will increase over the entire basin, relative to the 1986–2005 reference period, with greatest changes in the Upper Indus Basin (UIB). Heat waves are more likely to occur. An increase in summer temperature is projected, particularly for regions of higher altitudes in the UIB. The persistent increase of summer temperature might accelerate the melting of glaciers, and has negative impact on the local freshwater availability. Projections under all RCP scenarios show an increase in monsoon precipitation, which will increase the possibility of flood disaster. A decreasing trend in winter and spring precipitation in the IRB is projected except for the RCP2.6 scenario which will cause a lower contribution of winter and spring precipitation to water resources in the mid and high altitude areas of the IRB. [ABSTRACT FROM AUTHOR]