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Cochlear implant surgeries have become increasingly common in India, leading to a rise in complications such as cochlear implant exposure. To address this issue, we present a novel technique involving a single incision dual cover using the temporoparietal fascial flap (TPFF) and skin flap to give durable cover for exposed cochlear implants. Materials and Methods A retrospective study was conducted between December 2019 and December 2022 on patients who underwent the dual flap procedure for exposed cochlear implants. Results The average defect size was 2 × 2 cm, and the average length of hospital stay was 10 days. Fourteen skin flaps were closed primarily, while two required skin grafting for donor site closure. At the time of discharge, all wounds showed successful healing with intact skin coverage over the cochlear implant device site. The average follow-up period was 12 months, during which two patients had donor site scar alopecia, while others had adequate hair growth masking the scar. All patients consistently used their cochlear implants. Conclusion Our single-incision, dual cover TPFF + skin flap technique offers a reliable and innovative solution for managing exposed cochlear implants. With successful implant salvage and favorable postoperative outcomes, this approach demonstrates the versatility and reliability of the TPFF as an excellent option for reconstructive surgeons dealing with cochlear implant complications. [ABSTRACT FROM AUTHOR]

Background: Androgenetic alopecia (AA) is one of the common cosmetic concerns. It affects more than 50% of adults. AA alopecia is a benign condition and it affects the psychology of patients. Microneedling (MN) - minimally invasive procedure. Minoxidil is an antihypertensive and causes vasodilation. Aims and Objectives: The present study was aimed to compare the efficacy of MN with minoxidil solution versus MN with hair multivitamin solution of male androgenetic alopecia. Materials and Methods: The study was conducted in the Department of Dermatology, Akash Institute of Medical Sciences and Research Centre, Devanahalli, Bengaluru, Karnataka, India. After following inclusion and exclusion criteria, 50 subjects were involved. Subjects were divided into two groups, 25 in each group. Group I, MN with dermaroller having needle length of 1.5 mm was done and minoxidil solution was applied over the scalp and the again MN was done. Group II, MN was done and hair multivitamin solution was used. MN was done for every 3 weeks and a total of nine sessions were done. From the last session, all the study subjects were followed for 6 months. Baseline investigations were done. Side effects such as pain, bruising, and folliculitis were recorded and monitored. Response of the patients to the treatment (hair growth) was assessed by physician global assessment scores. Visual analog scale score was done to assess the subjective improvement of the patients. Results: In this study, 50 male androgenetic alopecia patients were involved. In this, 21 (42%) were in the age group of 20-40 years and 29 (58%) were in the 41-60 years of age group. In Group I, excellent response was seen in 19 (76%), very good response in 4 (16%), good response in 2 (8%) patients, and none of the patients showed average response. In Group II, excellent response was seen in 10 (40%), very good response in 4 (16%), good response in 6 (24%) patients, and average response in 5 (20%). Following side effects were observed in the study subjects, pain in 6 (24%), bruising 4 (16%), and folliculitis 2 (8%). Conclusion: MN is safe and cost-effective procedure, which causes stimulation of hair follicles and improves hair growth. [ABSTRACT FROM AUTHOR]

Introduction: Androgenetic Alopecia (AA) is characterised by progressive-patterned hair loss from the scalp affecting males and females alike. Miniaturisation of the hair follicle with associated hereditary tendency is one of the major primary causal factors for the pathogenesis of AA. Various treatment modalities have been proposed for the management of AA including minoxidil, finastride, etc.; however, they are associated with known side-effects. Aim: To evaluate the effect of intradermal Platelet Rich Plasma (PRP) administration, along with oral biotin supplement for the management of AA in males. Materials and Methods: The present randomised clinical study was conducted at Department of Dermatology, B.J. Medical College and Hospital, Ahmedabad, Gujarat, India from January 2012 to May 2013. A total of 40 healthy adult males of Indian origin, with a history of hair loss, completed the 12 month trial. They were equally randomised into two groups. Subjects enrolled in group A (n=20) received intradermal administration of autologous PRP, every 15 days for three months along with oral biotin tablets, once daily for three months, while those in group B (n=20) received oral biotin tablets, once daily for three months. Hair regrowth was evaluated using a standardised 7-point rating scale at 3, 6, 9 and 12 months intervals, by the same investigator. Chi-square test was used to statistically assess the data. The p-value for significance was established at <0.05. Results: Individuals in group A had mean age of 32.3±6.1 years and showed statistically significant (p-value <0.05) increase in hair regrowth at 6 months, 9 and 12 months; compared to Group B with mean age of 30.7±5.2 years. Conclusion: Intradermal administration of PRP along with oral biotin tablet supplementation resulted in a statistically significant increase in hair regrowth, without any remarkable side-effects. PRP is a safe and effective treatment modality in adult males, with AA. [ABSTRACT FROM AUTHOR]

Background: Blumea eriantha DC is the Indian medicinal remedy, mainly distributed in the States of India. It possesses wide array of medicinal properties. Aim: To execute green synthesis approach for the preparation of silver and iron nanoparticles by using alcoholic Blumea ErianthaDC extract and to verify the biological potential of the prepared nanoparticles as a hair growth promoter. Patients/Method: Extract was mixed with silver nitrate and ferric chloride for synthesis of silver and iron nanoparticles, respectively. Prepared nanoparticles were confirmed by UV, FT‐IR, SEM, X‐ray diffraction, and TEM. The qualitative and quantitative analysis was performed namely hair growth initiation, hair growth completion, hair length, hair weight, histopathological studies, skin thickness, and length of the hair follicle. Results: The prepared nanoparticles were observed as a blend of spherical and irregular shape with an average particle size of 35nm. The transition of anagen hair follicles was observed in approximately 63.43 % of animals treated with Minoxidil, whereas 2% and 5% Blumea erianthasilver nanoparticles treated animal group exhibited 33.02% and 60.93%, respectively. The animal groups treated with 2% and 5% iron nanoparticles of Blumea Eriantha showed 44.09 and 38.89% in anagen induction, respectively, which suggest the hair growth‐promoting potential of the extract of Blumea erianthaDC. Conclusion: Thus, it can be concluded that silver nanoparticles of Blumea Eriantha exhibit promising hair growth promoting activity. [ABSTRACT FROM AUTHOR]

In recent years, environmental issues emerging from per- and polyfluoroalkyl substances (PFAS) have raised high concern worldwide. Levels of human exposure to PFAS remain unknown in India. Biomonitoring data obtained from hair analysis have been evidenced to provide insight into retrospective human exposure to PFAS. In this study, 25 PFAS, including perfluoroalkyl acids and their precursors, were measured in 39 human hair samples collected from 14 cities in India. The inuflence of gender on the PFAS levels was also examined. To our knowledge, this is the first attempt to provide preliminary indicative data (due to the limited sample size and variability in hair-length sampling) on the levels of PFAS in Indian hair. The concentrations of total PFAS in hair varied from below matrix-specific limit of quantification (<0.02 ng/g) to 3.78 ng/g. Among 9 PFAS quantified, perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic acid (PFOS), and perfluorooctanoic acid (PFOA) were the predominant compounds. Categorized into 4 regions, PFAS contamination exhibited certain regional difference where South India may show higher levels than the other regions. Highly significant positive correlation was observed between PFHxS and PFOS (p ≪ 0.001; r = 0.644), suggesting similar pathways of exposure to the two compounds. Higher PFAS occurrence was generally observed in the hair of females. Our results highlighted the urgent need to investigate the deposition mechanism of PFAS in hair. Image 1 • This is the first nationwide biomonitoring of PFAS in Indians. • PFHxS, PFOS, and PFOA were predominant in hair samples collected in India. • N -EtFOSA and 6:2 FTUCA were firstly detected in human hair samples. • Regional difference in PFAS levels was found in Indian hair. • Gender might influence PFAS accumulation in hair. [ABSTRACT FROM AUTHOR]

Objective Safety and efficacy of microneedling with autologous platelet-rich plasma (PRP) in chronic and stable alopecia areata. Methods This study was conducted from September 2013-October 2015 and included 25 patients of alopecia areata attending dermatology OPD of Victoria Hospital and Bowring and Lady Curzon Hospital affiliated to Bangalore Medical College and Research Institute. Patients were included in the study based on the exclusion and inclusion criteria. It was conducted as a randomized prospective study for a period of 12 weeks. SALT score at the baseline and at the end of 12 weeks and hair regrowth at the end of 12 weeks was calculated to see the treatment response. Results Patients showed statistically significant hair regrowth and decrease in the SALT score from baseline at the end of 12 weeks. Conclusion Study concluded that microneedling with autologous PRP can serve as a safe and efficient treatment in cases of chronic and extensive alopecia areata for faster hair regrowth. [ABSTRACT FROM AUTHOR]

Hair loss is a dermatological condition or disorder. Hair loss is a great universal problem has affected both sexes of all races to different extents for as long as mankind has existed. Recent data shows hair loss trend Increased over the last 2 decades. Unlike many other areas of medicine, pharmacological treatments for alopecia are relatively new. There are only two treatments which are approved by the Food and Drug Administration (FDA); minoxidil and finasteride, the rest are drugs developed for other indications which have gained popular off label use to promote hair growth. Therefore it is of great importance, to develop new therapies for the treatment of hair loss. The traditional system of medicine in India acclaims a number of herbal drugs for hair growth promotion. Ayurveda has described hair diseases in three words: Khalitya means loss of hairs, Palitya means premature hair graying, Indralupta means Alopecia areata. Herbal cosmetics have burgeoning demand and in the world market and are an inestimable gift of nature. There are wide spans of herbal cosmetic products to satisfy beauty regime. The presence of number of phytochemicals and botanicals in the herbal products have dual stuff, one that they are used as cosmetics for body care and another that phytochemicals amend the biological functions of human body naturally results in healthy skin and hairs with less side effects. Present study was focussed on envisage formulating in-house polyherbal formulations using different herbs in varying ratios and formulations to evaluate for their hair growth initiating and hair growth promoting activity. [ABSTRACT FROM AUTHOR]

From ancient days to recent civilization, human beings depend on nature for running their life smoothly from day to day. Ayurveda, a system of medicine is based on natural remedies; it is ancient and effective as well. Triphala churna is an important ayurvedic formulation in India since ancient time. In present scenario various pharmaceutical and ayurvedic companies are manufacturing triphala churna but lack of standardisation of formulation is major stumbling block. In order to improve purity, efficacy and safety of product effective standardisation is a necessity and it also expands conviction of patient towards Ayurveda. When any drug or formulation is going to enter human body it should be of quality and does not produce any untoward effect. Triphala churna consist of three crude drugs that are Amla (Emblica officinalis), Bahera (Terminalia bellirica) and Harad (Terminalia chebula). Triphala churna is widely used for various ailments like digestive disorders, immuno-modulation, improvement of eye sight, hair growth etc. Present research work deals with comparative analysis of marketed triphala churna. For the purpose three brands name as Dabur, Patanjali and Baidyanath were selected. For standardization of triphala churna WHO guidelines were followed, various parameters of quality control were performed with all three samples selected for analysis. Morphological, physical and phytochemical analysis performed to standardise the samples selected, it includes organoleptic evaluation, phytochemical identification, powder characteristic determination, ash value determination, moisture content, extractive value etc. As Triphala churna contains three drugs and all drugs are claimed to contain tannins, the quantity of tannin was also determined. The comparative analysis of selected formulations showed satisfactory results. [ABSTRACT FROM AUTHOR]