1. Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications.
- Author
-
Ueta M, Kannabiran C, Wakamatsu TH, Kim MK, Yoon KC, Seo KY, Joo CK, Sangwan V, Rathi V, Basu S, Shamaila A, Lee HS, Yoon S, Sotozono C, Gomes JÁ, Tokunaga K, and Kinoshita S
- Subjects
- Adolescent, Adult, Alleles, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Brazil, Child, Dry Eye Syndromes ethnology, Dry Eye Syndromes etiology, Dry Eye Syndromes immunology, Epithelium, Corneal immunology, Epithelium, Corneal pathology, Ethnicity, Female, Gene Frequency, HLA-A2 Antigen immunology, HLA-B44 Antigen immunology, Humans, India, Male, Middle Aged, Multi-Ingredient Cold, Flu, and Allergy Medications adverse effects, Republic of Korea, Retinal Pigment Epithelium immunology, Retinal Pigment Epithelium pathology, Risk Factors, Stevens-Johnson Syndrome ethnology, Stevens-Johnson Syndrome etiology, Stevens-Johnson Syndrome immunology, Trichiasis ethnology, Trichiasis etiology, Trichiasis immunology, Dry Eye Syndromes genetics, HLA-A2 Antigen genetics, HLA-B44 Antigen genetics, Stevens-Johnson Syndrome genetics, Trichiasis genetics
- Abstract
Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs and multi-ingredient cold medications are reported to be important inciting drugs. Recently, we reported that cold medicine related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement including severe ocular surface complications (SOC) is associated with HLA-A*02:06 and HLA-B*44:03 in the Japanese. In this study, to determine whether HLA-B*44:03 is a common risk factor for CM-SJS/TEN with SOC in different ethnic groups we used samples from Indian, Brazilian, and Korean patients with CM-SJS/TEN with SOC, and investigated the association between CM-SJS/TEN with SOC and HLA-B*44:03 and/or HLA-A*02:06. We found that HLA-B*44:03 was significantly associated with CM-SJS/TEN with SOC in the Indian and Brazilian but not the Korean population, and that HLA-A*02:06 might be weakly associated in the Korean- but not the Indian and Brazilian population.
- Published
- 2014
- Full Text
- View/download PDF