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Objectives: The aim of this study is to assess the occurrence, reasons, and consequences of Emergency Peripartum Hysterectomy (EPH) at a particular institution. It seeks to identify risk factors, examine complications, and offer insights for interventions to enhance maternal and fetal outcomes in obstetric emergencies. Methods: The study was conducted at a tertiary care centre and the data analysis covered a period of 1 year. This study retrospectively analyzed Emergency Peripartum Hysterectomy (EPH) cases at a specific institution, reviewing patient demographics, obstetric history, booking status, referral patterns, EPH indications, delivery mode, and maternal-fetal outcomes. Results: The study revealed that the majority of patients (80.3%) belonged to rural backgrounds, with 89.3% being unbooked cases. Furthermore, 64.3% of cases were referred, and 85.7% of patients were in the P2,3,4 group. The most common indication for Emergency Peripartum Hysterectomy (EPH) was uterine rupture (53.6%), with a statistically significant association between the type of hysterectomy and indications for EPH (P value < 0.05). Subtotal hysterectomy was performed in 82.1% of cases, and maternal complications included febrile illness (51.8%) and wound infection (37.5%). Conclusion: This study highlights the imperative to address the elevated incidence of Emergency Peripartum Hysterectomy (EPH) in rural healthcare in India. The findings stress the pressing need for targeted interventions, including improving female literacy, increasing contraception prevalence, and enhancing antenatal care accessibility and quality. Strengthening peripheral healthcare, ensuring timely referrals for high-risk pregnancies, and proper documentation are essential for mitigating maternal morbidity, mortality, and foetal complications. [ABSTRACT FROM AUTHOR]

Objective: Polycystic ovary syndrome (PCOS) is a complex disorder with diverse metabolic implications. Diagnosis typically relies on oligo‐amenorrhoea (OA), hyperandrogenism (HA), and polycystic ovarian morphology (PCOM). However, the role of polymenorrhoea in PCOS remains understudied. Additionally, limited information exists regarding metabolic disturbances in women with partial PCOS phenotypes that do not meet diagnostic criteria. This extensive database aims to provide substantial evidence on the metabolic implications of polymenorrhoea and partial PCOS phenotypes. Design: Prospective observational study. Patients and Measurements: In this single‐centre study, 6463 women with PCOS‐like characteristics and 3142 age‐matched healthy women were included. The study compared clinical (anthropometry, modified Ferriman Gallwey [mFG] score), hormonal (serum testosterone), and metabolic (plasma glucose, serum lipids, insulin) characteristics between women diagnosed with PCOS, those with partial PCOS phenotypes, and the healthy control group Results: In all, 5174 women met Rotterdam criteria for PCOS diagnosis, while 737 were classified as Pre‐PCOS, including HA (n = 538), OA (n = 121), or PCOM (n = 78). Common clinical features included oligomenorrhoea (75.5%), hirsutism (82.9%), obesity (27.2%), hypertension (1.6%), metabolic syndrome (19.6%), and diabetes mellitus (5.6%). Women diagnosed with PCOS, HA only, and OA only exhibited higher average body mass index, plasma glucose levels (both fasting and 2 h after the oral glucose tolerance test), and lipid fractions in comparison to those with PCOM and the healthy controls. However, indices of insulin resistance were similar among women with PCOS, HA, PCOM, and OA, albeit higher than in the healthy controls. The polymenorrhoea subgroup (5.9%) had lower BMI and serum testosterone, but similar mFG score, plasma glucose, insulin, and lipid levels as the oligomenorrhoea subgroup. Conclusion: The metabolic disturbances observed in Pre‐PCOS women highlight the need to reassess diagnostic criteria. Including the polymenorrhoea subcategory in PCOS criteria is recommended due to similar metabolic dysfunctions as the oligomenorrhoea group. [ABSTRACT FROM AUTHOR]

To deliver the full science potential of the square kilometer array (SKA) telescope, several SKA regional centres (SRCs) will be required to be constructed in different SKA member countries around the world. These SRCs will provide high performance compute and storage, for the generation, of advanced science data products from the basic data streams generated by the SKA science data handling and processing system, critically necessary to the success of the key science projects to be carried out by the SKA user community. They will also provide support to astronomers to enable them to carry out analysis on very large SKA datasets. Construction of such large data centre is a technical challenge for all SKA member nations. In such a situation, each country plans to construct a smaller SRC over the next few years (2022 onwards), known as a proto-SRC. In India, we propose to construct a proto-SRC, which will be used for the analysis of data from SKA pathfinders and precursors with strong Indian involvement, such as uGMRT, Meerkat and MWA. We describe our thinking on some aspects of the the storage, compute and network of the proto-SRC and how it will be used for data analysis as well as for carrying out various simulations related to SKA key science projects led by Indian astronomers. We also present our thoughts on how the proto-SRC plans to evaluate emerging hardware and software technologies and to also begin software development in areas of relevance to SKA data processing and analysis, such as algorithm implementation, pipeline development and data visualisation software. [ABSTRACT FROM AUTHOR]

Cross-disciplinary scholarship on platform-mediated transformations is growing rapidly. Large-scale data centers that aggregate hardware resources are an important element shaping the expansion of platform economies. The impact of this configuration of hardware on the dynamics of software development is still unclear. Data centers aggregate and centralize computing capacity and in turn enable the growth of globally distributed and organizationally decentralized corporate ecosystems. Scholarship in this area is beginning to examine the relations between dominant technology corporations and their networks of users and third-party companies. I contribute to literature on platform ecosystems by examining changing organizational and market dynamics introduced by cloud computing within the corporate computing sector. Drawing on qualitative interviews with managers of software startups in India, I focus on falling barriers to entry, new organizational forms, and emergent transnational dimensions. Using this case, I theorize monopolization as being embedded in competitive ecosystem dynamics. [ABSTRACT FROM AUTHOR]

Background & objectives: The World Health Organisation recommended immediate initiation of antiretroviral therapy (ART) in all adult human immunodeficiency virus (HIV) patients regardless of their CD4 cell count. This study was undertaken to ascertain the cost-effectiveness of implementation of these guidelines in India. Methods: A Markov model was developed to assess the lifetime costs and health outcomes of three scenarios for initiation of ART treatment at varying CD4 cell count <350/mm³, <500/mm³ and test and treat using health system perspective using life-time horizon. A few input parameters for this model namely, transition probabilities from one stage to another stage of HIV and incidence rates of TB were calculated from the data of Centre of Excellence for HIV treatment and care, Chandigarh; whereas, other parameters were obtained from the published literature. Total HIV-related deaths averted, HIV infections averted and incremental cost-effectiveness ratio per quality adjusted life years (QALYs) gained were calculated. Result: Test and treat intervention slowed down the progression of disease and averted 18,386 HIV-related deaths, over lifetime horizon. It also averted 16,105 new HIV infections and saved 343,172 QALYs as compared to the strategy of starting ART at CD4 cell count of 500/mm³. Incremental cost per QALY gained for the immediate initiation of ART as compared to ART at CD4 cell count of 500/mm³ and 350/mm³ was ₹ 46,599 and 80,050, respectively at reported rates of adherence to the therapy. Interpretation & conclusions: Immediate ART (test and treat) is highly cost-effective strategy over the past criteria of delayed therapy in India. Cost-effectiveness of this policy is largely because of reduction in the transmission of HIV. [ABSTRACT FROM AUTHOR]

The novelty of this study consists, use of the Powder X-Ray Diffraction (PXRD) technique facility at CSIR-NGRI to report the occurrence of platinum and skaergaardite (Pd Cu) in the Hutti underground gold mines. This study utilized a quartz-bearing sample from the Hutti underground gold mines. One of the split samples were analyzed by PXRD. In this study, quartz samples are found to be associated with sulphides composed of pyrite, chalcopyrite, and arseno-pyrite with intense chemical alterations. The mineral phase of skaergaardite shows a strong intensity at 2θ 43.5° and confirmed with database of International Centre for Diffraction Data Powder Diffraction File — ICDD-2021-PDF4+ PDF00-057-0606 and native platinum, syn (Pt) Pt 0.0999 Sn 0.001 matched with PDF 04-001-3300. Further research work is planned on this interesting mineral association with primary gold ore in Hutti underground gold mine. [ABSTRACT FROM AUTHOR]

The heatwave is a disastrous hazard having significant impacts on health and society. This study analyses the heatwave hazards and risk for India's current and future scenarios using socioeconomic vulnerability and temperature datasets during the summer (April–June) season. The Census of India (CoI) 2011 datasets were considered to assess current vulnerability and projected from the SocioEconomic Data And Application Center (SEDAC) population at Shared Socioeconomic Pathway (SSP) 4 for future vulnerability. Whereas IMD temperature data used for hazard assessment for the present scenario (1958–2005) while projected temperature data from regional earth system model REMO-OASIS-MPIOM (ROM) were used for the future (2006–2099) scenario. The study exhibited the most hazardous, vulnerable, and risk-prone regions identified as the south-eastern coast and Indo-Gangetic plains and some populous districts with metropolitan regions (Mumbai, Delhi, and Kolkata) under the current scenario. The coupled model ROM has efficiently captured the critical districts with higher and lower risk, showing its future projection capability. The study highlighted that the heatwave hazard-risk would significantly worsen in future scenarios in all districts under enhanced global warming and largely affecting the districts in the eastern and middle Indo-Gangetic plains and Malabar region. The present study will provide sufficient insights into designing mitigation strategies and future adaptive planning for the heatwave risk, which is one of the targets under Sustainable Development Goal 13 (Goal 13: Climate Action). • The present and future vulnerability and risk are assessed over India using a regional earth system model ROM. • The ROM efficiently captured the high and low heatwave risk districts of India. • Southern coastal regions and Indo-Gangetic plains are at higher risk during the baseline period 1980–2005. • The heatwave risk will exacerbate in all districts of India with the highest increment over Indo-Gangetic plains. [ABSTRACT FROM AUTHOR]