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Rare Earth Elements (REE) are the industrial “Vitamins” because of the high-technology based modern uses and their anthropogenic inputs in natural environment, this study mainly focused on Geogenic variability and anthropogenic imprints of Light Rare Earth Elements (LREE), in the recently deposited sediments of the Ganga Alluvial Plain. All the Sediment samples were analyzed by using Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). LREE comprises about ~91% of total REE in the Gomati River Sediments and Cerium (300 µg/g) was the most abundant LREE in the bedload sediments. Average LREE concentrations in bedload (170 µg/g) and suspended load (184 µg/g) sediments of the Gomati River were observed higher than the Average Sediments and the World Major Rivers Suspended Sediments and therefore, characterizing the LREE contamination in sediments. This contamination level assessed on the basis of Potential Ecological Risk Assessment (PERI), Contamination Factors (CF), Degree of Contamination (CD) and Geo-accumulation Index (Igeo), the trend of element contamination showed that Sm>La>Pr>Ce>Nd and PERI shows that LREE pose moderate to strong ecological risk, mostly by Pr and Sm in the study area. The spatial and temporal enrichment of LREE in sediments were observed in the Basin since last two decades. This paper mainly highlights the effects of socio-economic development linked modern high-tech processes on LREE contamination in the river sediments and cycling by the sub-tropical fluvial environment of southern Asia; where rivers supply ~30% of the global sediment input to the world’s ocean. [ABSTRACT FROM AUTHOR]

Introduction: Essential herbs such as garlic, ginger, and cardamom have shown antimicrobial activity with no potential adverse effects and are cost-effective. Despite these advantages, the efficacy of these agents needs to be tested against common oral pathogenic microorganisms to ensure that if found effective, they can be used in clinical settings. Aim: To evaluate and compare the effectiveness of garlic, ginger, and cardamom oils on Streptococcus mutans (S. mutans) against chlorhexidine. Materials and Methods: An in-vitro study was conducted at Bharati Vidyapeeth Dental College and Hospital, Navi Mumbai, in the Department of Microbiology and Bharati Vidyapeeth College of Pharmacy, Navi Mumbai, Maharashtra, India from January 2023 to September 2023. Oil extracts of garlic, ginger, and cardamom were loaded onto sterile filter paper discs measuring 6 mm in diameter in concentrations of 50 µL, 100 µL, and 200 µL. Additionally, 2% chlorhexidine (control group) was loaded onto similar sterile paper discs. The discs were dried and placed aseptically on culture media plates inoculated with S. mutans, and the plates were then incubated at 37°C overnight. Subsequently, the zones of inhibition were measured in millimeters. Results: Ginger oil exhibited the highest zone of inhibition, measuring 25 mm, followed by cardamom oil and garlic oil measuring 18 mm and 12 mm, respectively, at a concentration of 200 µL. The zone of inhibition measured for 100 µL concentrations of garlic, ginger, and cardamom oils were 7 mm, 16 mm, and 13 mm, respectively. For 50 µL concentrations of the oils, the zones of inhibition for garlic, ginger, and cardamom were 0 mm, 13 mm, and 9 mm, respectively. The zone of inhibition shown by chlorhexidine was 22 mm for concentrations of 50 µL, 100 µL, and 200 µL. Conclusion: Essential oil extracts from ginger, cardamom, and garlic were found to have antimicrobial activity against S. mutans, with ginger oil showing the highest effectiveness, followed by cardamom oil and garlic oil. [ABSTRACT FROM AUTHOR]

Purpose: Human capital is a portfolio of rich skills that the labour possesses. Human capital has attracted significant attention from scholars. Nevertheless, empirical findings on the utility of human capital have often been divided. To address the research gap in the literature, the authors attempt to understand how human capital plays a significant role in financial development and economic growth nexus. Design/methodology/approach: The authors rely on secondary data published by the World Bank. The authors use econometric tools such as the autoregressive distributive lag (ARDL) model and related statistical tests to study the relationship between human capital, India's financial growth and gross domestic product (GDP) growth. Findings: Study findings suggest that human capital and financial development contribute significantly to economic growth. Further, the authors found that human capital has a positive and significant moderating effect on the path of joining financial development and economic growth. Practical implications: The study contributes to the human capital debate. Despite the rich body of literature, the study based on World Bank data confirms the previous findings that investment in human capital is always useful for the financial and economic growth of the nation. Originality/value: This paper reveals some unique findings regarding effect of financial development and economic growth nexus which opens the window of new dimension to think about their nexus. It also provides a different pathway to foster the economic growth by using human capital and financial development as together, especially in India. [ABSTRACT FROM AUTHOR]

Background: Genetic testing for Breast Cancer (BRCA) gene 1 and 2 mutations in epithelial ovarian cancers is recommended to guide prognosis, adjuvant treatment and prevention of second malignancies in the patient and in the carrier family members or relatives. Prevalence of BRCA and other cancer-causing mutations is not known in most regions in India and is inadequately explored. Main-streaming genetic testing has the potential to increase uptake of testing in patients and identify at-risk carrier population in whom primordial or primary prevention of genetic cancers can be implemented with good outcomes. Materials and Methods: A mixed method study was conducted with aim to explore feasibility of a primary care nurse based genetic counselling modality for ovarian cancer patients, along with exploration of factors affecting its uptake, using a structured objective survey questionnaire followed by key informant interviews to develop qualitative questionnaire for further phase of the study. Results: The uptake of genetic testing among patients was good and among healthy relatives was negligible. The affecting factors were lack of awareness and economic. The qualitative study interview explored reasons for low uptake of tests, satisfaction with the counselling and impact of test results on patients. Conclusion: The pretest counselling was effective and post-test counselling necessitated counselling by specialist oncologist. The uptake of genetic testing was affected by level of awareness and costs. [ABSTRACT FROM AUTHOR]

The study using cross‐sectional data collected from 300 dairy farmers has analyzed the factors affecting adoption of improved forage technologies and its impact on milk yield and feed sufficiency in central region. We used inverse‐propensity‐weighting regression adjustment (IPWRA) method as main technique for impact evaluation and checked the robustness of the results using matching methods. Our findings suggest that education status, adult cattle unit, animal breed type, off‐farm income activities, farm size, and access to training and market significantly influence adoption of improved forage technologies and practices. Further, the adoption led to a significant increase in daily milk yield (1.07 to 1.34 L), total dry matter availability by over 27%, and green fodder availability by around 80%. Ration balancing has been identified as a significant concern in the study region. Consequently, the study suggests that adopting a comprehensive approach is necessary to address the issue of proper ration balancing and fully harness the production potential of dairy animals. [ABSTRACT FROM AUTHOR]

Background: Surgical site infections (SSIs) are infections of the tissues, organs, or spaces exposed by surgeons while performing an invasive procedure. SSI is one of the most common healthcare-associated infections, but its importance as a health-care priority is not fully understood, and limited work has been published defining the role of surgeons in SSIs. Aims and Objectives: In the present study, we assess the burden of SSI after gastrointestinal (GI) surgery in a tertiary care hospital in the Central India. Materials and Methods: The present study was conducted on patients admitted to Gandhi Medical College-affiliated Hamidia Hospital, Bhopal, in the General Surgery Department. The study included 207 patients who underwent emergency/routine GI surgeries between September 2020 and April 2022. Patient characteristics and laboratory data were recorded on a pre-designed form, and all patients were evaluated postoperatively for soakage along with culture and antibiotic testing. Results: The overall incidence of SSI was 42.51% and its distributions between emergency and routine surgeries were 22.7% and 19.8%, respectively. SSI was predominant in male patients. White blood cell level was significantly associated between emergency and routine surgeries, while Hb level, serum protein level, and the time required for surgery were insignificant. SSI under contaminated dirty wounds was prevalent in both emergency and routine surgeries. Klebsiella was the most commonly isolated organism, followed by Escherichia coli. The commonly susceptible antibiotics have been found to be meropenem, pipzo, amikacin, and imipenem. Commonly resistant antibiotics were amoxiclav, ceftriaxone, linezolid, and doxycycline. Conclusion: This paper presents the incidence of SSI in the hospital setting of Central India and the factors that may contribute to the high incidence of SSI. Further research needs to be done to better understand how specific risk factors are responsible for post-operative wound infections in open GI surgery. [ABSTRACT FROM AUTHOR]

Introduction: Spinopelvic malalignment causes continual backache. Intervertebral Disc Degeneration (IDD) is a leading cause of low backache. Understanding the relationship between spinopelvic parameters and IDD can help with better diagnosis and treatment and avoid unnecessary investigations. Aim: To measure radiographic spinopelvic parameters of patients diagnosed with varying grades of IDD in the lumbosacral spine on Magnetic Resonance Imaging (MRI), and to compare them with radiographs of the asymptomatic population (controls). Materials and Methods: A hospital-based retrospective observational study was done from January 2021 to August 2022 at a tertiary care hospital in Uttar Pradesh, India with 80 patients diagnosed with IDD on MRI and 80 controls. Cases were defined as patients diagnosed to have IDD on MRI and controls were those individuals who did not have disc degeneration on MRI. Lateral lumbosacral spine radiographs were taken, and spinopelvic parameters {Pelvic Tilt (PT), Sacral Slope (SS), Pelvic Incidence (PI), Lumbar Lordosis (LL), lumbo-sacral angle, and sacral horizontal angle} were measured using Surgimap Spine Software. T-test and Chi-square test were used for comparison between cases and controls. Results: Six patients had asymmetric disc bulge, 11 had symmetric disc bulge, 18 had disc extrusion and 45 had disc protrusion. Mean PT in patients with IDD was 11.05±3.84°, and control was 8.65±3.19°, p-value=0.009. Mean SS in case group was 38.38±3.03° and control was 36.56±3.43°, p-value=0.031. The mean PI of cases was 49.44±8.39° and control 46.19±9.01°, p-value=0.02. LL angle was higher in IDD at 46.34°, and was 45.36° in healthy individuals, without statistically significant difference. The mean lumbo-sacral angle in both study groups was similar. The mean Sacral Inclination Angle (SIA) was found to be 43.99° and 44.96° in the case and control group respectively without showing significant differences. A statistically significant difference was found only for the comparison of PT between different grades of IDD (p-value=0.039). Conclusion: Using Surgimap Spine Software, one can predict the individuals that possess a greater propensity of developing degeneration of disc and chronic low back pain in a more costeffective manner. [ABSTRACT FROM AUTHOR]

India Meteorological Department (IMD), Ministry of Earth Sciences (MoES) in collaboration with Indian Council of Agriculture Research (ICAR), State Agriculture Universities (SAUs), Indian Institute of Technology (IITs) and other organizations is rendering weather forecast based District level Agrometeorological Advisory Service (AAS) for benefits of farmers in the country under the centrally sponsored scheme 'Atmosphere & Climate Research-Modelling Observing Systems & Services (ACROSS) ' of MoES. AAS, popularly known as Gramin Krishi Mausam Sewa (GKMS) provides advance weather information along, with crop specific agromet advisories to the farming community by using state of the art instruments and technology through efficient delivering mechanism of the information which ultimately enables farmers to take appropriate actions at farm level. The various components of GKMS viz. observing weather, its monitoring and forecast; crop specific advisory bulletin generation and dissemination; outreach and feedback have been/are being digitized to support integrating all the components of information generation and action suggested linked to these information. An Information and Communication Technology (ICT) based Agromet Decision Support System is developed for automation of the services provided under GKMS. This includes a dynamic framework to link the information of weather forecast, real time weather observation, crop-weather calendar etc. to translate weather forecast into actionable farm advisories for efficient farm level decision making in India. Apart from this, effort is being made to develop recent technology driven tools to estimate future yield of crops and prepare an irrigation schedule without a need of multiple parameters. [ABSTRACT FROM AUTHOR]

This study, using cross sectional data from 170 farmers, empirically established that agroforestry positively affects food security and significantly reduces income variability among farmers in Bundelkhand region lying in semi-arid tropics of central India. A 1% increase in the tree density and tree diversity on farm significantly increases food security status by 0.231% and 0.141% points, respectively. Further variability in income reduces by around 0.38% and 0.16% with unit percentage increase in tree density and diversity, respectively. Therefore, amid the epoch of global climate change, agroforestry practice can be a crucial climate smart agriculture option. Farmers' challenges were also identified and ranked by using Problem Confrontation Index (PCI). The study unveils that, efforts towards controlling stray animals, creating marketing environment, strengthening and streamlining the extension services for more technological and input support requires a strategic institutional framework as a key to upgrade agroforestry in the region. [ABSTRACT FROM AUTHOR]

Increasing the taxonomic resolution of fossil pollen identification and establishing the kinship and similarity among phylogenetically related plant groups are inevitable for advancing the Quaternary palaeoecological, palaeoclimatological and palaeoenvironmental research. We, in the present study, examined and determined the pollen morphological characteristics of nine plant taxa belonging to seven families from central India by a combined light microscopic (LM) and confocal laser scanning microscopic (CLSM) study. The prime object was to observe, document and describe, as well as illustrate the prevalent variation in pollen shape, size, aperture number and diameter, diameter of the polar axis and equatorial distance, as well as exine thickness and pattern (i.e. pollen wall architecture) of the studied plant taxa. Pollen identification key was developed to demonstrate variations in pollen features and delimit taxa for correct identification. Principal component analysis (PCA) suggests exine and aperture number as dominant characters, as well as hierarchical clustering analysis (HCA), applied to the pollen morphological characters of nine plant taxa to understand the variability among the taxa, and to cluster them, respectively, suggest three clusters. The cophenetic correlation coefficient also substantiates the three group of clustering. The present study has significance in taxonomy and systematics, as well as in phylogeny and evolution. In addition, the preservation potential of different pollen grains has been ascertained, based on the pollen wall architecture. The study, moreover, will improve the precise fossil pollen identification, which is critical for advancing Quaternary palaeoecology in India and also in similar tropical and subtropical areas of the globe. [ABSTRACT FROM AUTHOR]

This study assessed the impact of improved green fodder production activities on technical efficiency (TE) of dairy farmers in climate vulnerable landscapes of central India. We estimated stochastic production frontiers, considering potential self-selection bias stemming from both observable and unobservable factors in adoption of fodder interventions at farm level. The empirical results show that TE for treated group ranges from 0.55 to 0.59 and that for control ranges from 0.41 to 0.48, depending on how biases are controlled. Additionally, the efficiency levels of both adopters and non-adopters would be underestimated if the selectivity bias is not appropriately accounted. As the average TE is consistently higher for adopter farmers than the control group, promoting improved fodder cultivation would increase input use efficiency, especially in resource-deprived small holder dairy farmers in the semi-arid tropics. [ABSTRACT FROM AUTHOR]

Omicron was detected in South Africa for the first time at the month of November 2021, from then it expanded swiftly over the world, outcompeting other SARS-CoV-2 variants such as Delta. The toxicity, resistance to antiviral medicines, transmissibility, and vaccine-induced immunity of newly developed SARS-CoV-2 variants are major worldwide health concerns. This study investigates the comprehensive explanation of all mutations and their evolutionary linkages between the Omicron variant and recently discovered SARS‐CoV‐2 variants. On Illumina MiniSeq Machine, 31 RNA isolates from clinical specimens were sequenced utilizing next-generation sequencing technique. Different bioinformatics tools have been used to analyze the mutations in omicron variant. A phylogenetic tree was constructed to determine Omicron's evolutionary relationships with other variants. In our investigation, we discovered 79 distinct types of mutations in 31 fully vaccinated COVID-19 positive samples. Mostly mutations were found in non-spike region. According to the NJ approach of phylogenetic tree revels, the nearest variants were in the order listed, based on sequence identity: Omicron, Gamma, Alpha, Delta, Mu and Beta. On the other hand as per UPGMA approach, the Omicron variation creates a novel monophyletic clade that is distinct from previous SARS-CoV-2 variants. Despite the fact that some of the mutations are prevalent in Omicron and other VOCs, there are several unique mutations that have been connected to the virus's transmissibility and immune evasion, indicating a substantial shift in SARS-CoV-2 evolution. [ABSTRACT FROM AUTHOR]

Mucormycosis emerged as a major public health challenge during the second wave of the COVID-19 pandemic in India in mid-2021. The disease, colloquially known as the Black fungus, was declared epidemic by the government. This review describes the epidemiological pattern and the determinants of mucormycosis. The review also proposes evidence based public health strategies for the prevention and control of mucormycosis. The rationale use of steroids in clinical management, formulation of evidence-based standard treatment guidelines and adherence to those guidelines by physicians, the strengthening of primary healthcare services to facilitate early care; compliance with infection prevention and control measures at all the health facilities; and early diagnosis and case management are the key strategies to prevent future emergence of mucormycosis. The article concludes that it is not enough that we tackle a health challenge at hand, in crisis mode. It is equally important that we derive learnings and take measures prevent any future. Effective control of mucormycosis and prevention of future outbreaks of disease is possible through coordinated actions of health policy makers, public health experts and clinicians. The entire episode is also a reminder for strengthening India's health systems at all levels – primary, secondary and tertiary – as well as in both public and private sector. [ABSTRACT FROM AUTHOR]

Breakthrough infections with SARS-CoV-2 Delta variant have been reported in doubly-vaccinated recipients and as re-infections. Studies of viral spread within hospital settings have highlighted the potential for transmission between doubly-vaccinated patients and health care workers and have highlighted the benefits of high-grade respiratory protection for health care workers. However the extent to which vaccination is preventative of viral spread in health care settings is less well studied. Here, we analysed data from 118 vaccinated health care workers (HCW) across two hospitals in India, constructing two probable transmission networks involving six HCWs in Hospital A and eight HCWs in Hospital B from epidemiological and virus genome sequence data, using a suite of computational approaches. A maximum likelihood reconstruction of transmission involving known cases of infection suggests a high probability that doubly vaccinated HCWs transmitted SARS-CoV-2 between each other and highlights potential cases of virus transmission between individuals who had received two doses of vaccine. Our findings show firstly that vaccination may reduce rates of transmission, supporting the need for ongoing infection control measures even in highly vaccinated populations, and secondly we have described a novel approach to identifying transmissions that is scalable and rapid, without the need for an infection control infrastructure. [ABSTRACT FROM AUTHOR]

The global widespread of Corona virus disease is still having a catastrophic impact on mankind. COVID-19 has depicted its uncertain adversity in all age groups and the coexistence of co-morbidities have further shown a critical aspect of disease which has additionally ravaged the health status of the patients. The inflammatory markers have exhibited potential usefulness in predicting the outcome of the disease. The Aim of this study is to evaluate the correlation of inflammatory markers in COVID-19 positive patients among various age groups. The study was done on 225 COVID-19 patients, admitted to Mayo Institute of Medical Sciences, Barabanki, Uttar Pradesh India, between 1st April15th June 2021 categorizing into two groups based on their age (≤45 years and >45 years) and then values of various markers were gathered and compared. Among the 225 admitted COVID-19 patients, 78(34.6%) were ≤45 years, while the remaining 147(65.4%) were >45 years. Between these two age groups the aberrant values of inflammatory makers like Neutrophil count (p=0.0001), Lymphocyte count (p=0.0001), Neutrophil to Lymphocyte Ratio (NLR) (p=0.0091), Serum CRP level (p=0.0437), Lymphocyte to C-reactive protein ratio (LCR) (p=0.0007) as well as Serum Ferritin level (p=0.0097) were found to be statistically significant whereas the remaining parameters like Total leucocyte count (TLC) (p=0.0905), Platelet count (p=0.8202) and Platelet to lymphocyte ratio (PLR) (p=0.1513) were statistically insignificant. The results conclude that there was a significant correlation between the age and the inflammatory markers in these patients. Patients with > 45 years had elevated/deranged levels of inflammatory markers, which were associated with the severity and poor prognosis of the disease. Thus, age can be considered as one of the important key risk factor for the severity of COVID-19 in both sexes and hence more clinical attention should be given to elderly age group. [ABSTRACT FROM AUTHOR]

Introduction: Primary hyperparathyroidism (PHPT) in India is mostly symptomatic with renal and skeletal complications. Evidence on mortality outcomes following parathyroidectomy from India, where the disease is predominantly symptomatic is limited. Material and methods: This was a prospective study to evaluate mortality outcomes in the Indian PHPT registry over the past 25 years (n = 464). Pre- and postoperative parameters and mortality data were obtained from medical records and/or by verbal autopsy, a method validated by WHO for data collection in settings where several deaths are noninstitutional. Patients were divided into survivor (SG) and nonsurvivor groups (NSG) to ascertain differences in presentation and the effect of parathyroidectomy. Results: The overall mortality was 8.8% at a median follow-up of 8 years (IQR 1–13) after parathyroidectomy. Chronic kidney disease was the most common background cause of death (43.5%), followed by pancreatitis (28.2%). NSG had significantly more frequent renal dysfunction (91.9% vs 73.9%), anaemia (50 vs 16.6%) and pancreatitis (24.3 vs 6.4%). PTH (61.9 vs 38.3 pmol/l) and baseline creatinine (97.2 vs 70.7 µmol/l) were significantly higher and eGFR lower (66.7 vs 90.7 ml/min/1.73m2) in the NSG than SG. By Cox proportional modelling, renal dysfunction [HR 2.88 (1.42–5.84)], anaemia [HR 2.45 (1.11–5.42)] and pancreatitis [HR 2.65 (1.24–5.66)] on univariate and renal dysfunction [HR 3.33 (1.13–9.77)] on multivariate analysis were significant for mortality. Survival curves demonstrated a significantly higher mortality with lower eGFR values. Conclusions: Nonsurvivors in PHPT had greater prevalence and more severe baseline renal dysfunction than survivors. Survival after parathyroidectomy was significantly associated with estimated glomerular filtration rate at baseline. [ABSTRACT FROM AUTHOR]

Background: Estimation of fetal weight is at most important in effective managing of obstetric labour. Ultrasound is a standard technique to measure the weight but there is scarcity of ultrasonography at remote areas. In such situations clinical techniques can be considered for fetal weight calculation. Our study has compared both clinical methods and ultrasonography (USG) and to correlate with true weight at birth. Objective: To compare the fetal weight estimation by clinical methods and ultrasonographic method and its comparison with true birth weight in pregnancy at term. Material and Methods: A diagnostic study (Longitudinal study) was carried out at the Obstetrics and Gynaecology Department at tertiary care hospital to compare the precision of clinical and USG estimation of weight of the fetus with actual birth weight at term. One hundred pregnant women satisfying the criteria were considered and consent for the study were enlisted. Both USG and clinical methods were used. The fetal weight calculated by the above three methods was compared with true birth weight of the baby. Analysis of the precision of the various methods was done. Results: In our study population, the mean age was 25.29±4.45. The average absolute error by EFW (estimated fetal weight)-USG method was least, 117.81g. Among the clinical methods the average absolute error by EFW-Dare's was least i.e. 145.40g. The Correlation Co-efficient was highest with USG method (0.80) of estimation of fetal weight. Among clinical methods, Johnson's formula had highest R Value of 0.79 followed by Dare's formula at 0.76. The EFW using both Dare's formula and Johnson's formula had an excellent predictive validity in predicting actual weight. The EFW using Johnson's formula had sensitivity of 76.06% and Dare's formula had sensitivity of 73.24% in predicting actual weight. The EFW using USG method had highest sensitivity of 80.28%. It was seen in this study that clinical methods can reliably estimate EFW and can be used in settings where USG is not available. Conclusion: Estimation of fetal weight by clinical techniques has a significant role in obstetric labour and delivery. The clinical methods are easy and cost effective and applicable universally in predicting fetal weight. They can be used even by midwives and in remote areas where Ultrasonography is not readily available. It can be used as an integral part in the management of obstetric labour and delivery in remote primary health centres. [ABSTRACT FROM AUTHOR]

Diabetes is one of the most prevalent non-communicable diseases and is the 6th leading cause of death worldwide. It's a chronic metabolic disorder which has no cure, however, it is a highly treatable condition, if diagnosed and managed on time to avoid its complications. This paper explores and compares various machine learning (ML) approaches that can help in determining the risk of diabetes at an early stage and aid in improving the medical diagnosis of diabetes. The paper considers two real-world datasets one is a diabetic clinical dataset (DCA) collected from a medical practitioner in the state of Assam, India during the year 2017–2018 and other is public PIMA Indian diabetic dataset. To analyze the various machine learning techniques on DCA and PIMA Indian diabetic datasets for the classification of diabetic and non-diabetic patients, different classifiers like perceptron, Gaussian process, linear discriminant analysis, quadratic discriminant analysis, statistical gradient descent, ridge regression classifier, support vector machines, k-nearest neighbors, decision tree, naïve Bayes, logistic regression, random forest and ELM for multiquadric, RBF, sigmoid activation functions are used. The results of numerical experiments suggested that logistic regression yields better performance in comparison to the other techniques. [ABSTRACT FROM AUTHOR]

Background: High-altitude pulmonary edema (HAPE) is a common cause of hospitalization in high altitude areas with significant morbidity. The clinical presentation of HAPE can overlap with a broad spectrum of cardiopulmonary diseases. Also, it is associated with varied radiological manifestations mimicking other conditions and often leading to unnecessary and inappropriate treatment. Patients and methods: The primary aim of the study was to study the various radiological manifestations of HAPE through real-world chest radiographs. We present six different chest X-ray patterns of HAPE as a pictorial assay, at initial presentation, and after the resolution of symptoms with supplemental oxygen therapy and bed rest alone. Results: HAPE can present as bilateral symmetrical perihilar opacities, bilateral symmetrical diffuse opacities, unilateral diffuse opacities, bilateral asymmetrical focal opacities, and even lobar consolidation with lower zone or less commonly upper zonal predilection. These presentations can mimic many common conditions like heart failure, acute respiratory distress syndrome, pulmonary embolism, aspiration pneumonitis, pneumonia, malignancy, and tuberculosis. Conclusion: A holistic clinical--radiological correlation coupled with analysis of the temporal course can help high-altitude physicians in differentiating true HAPE from its mimics. [ABSTRACT FROM AUTHOR]

Rare earth elements (REE) are emerging as modern high-technology-related novel micro-contaminants in freshwater aquatic systems and are therefore attracting global attention due to their potential human health risks. The Gomati River (a tributary of the Ganga River) sediments were analyzed for REE concentrations to establish REE contamination and to identify biotite mica mineral as a geoindicator. Chondrite-normalized REE pattern of the river sediments and biotite mica mineral were similar and depict a strong light REE (LREE) enrichment and relatively flatter heavy REE (HREE). The maximum total REE (∑REE) concentration increased from 323 µg/g in 2012 to 673 µg/g in 2019. In the ∑REE, LREE contribution was > 80%, because of anthropogenic inputs, mainly petroleum-cracking catalysts and other high-technology-based products. The XRD analysis and the geochemical signature of the Gomati River sediments reveal the meaningful existence of biotite mica mineral. A distinct downstream REE enrichment pattern was identified in biotite from the mica-rich bedload sediments. The scanning electron microscopy-energy dispersive X-ray (SEM-EDX) mapping images of biotite also revealed the precipitation of Lanthanum, at the weathered edges, during the early stage of mineral weathering. Biotite mica was identified as a geoindicator for the assessment of REE contamination in the Gomati River and the Hindon River Basin of the Ganga Alluvial Plain. Future research is needed for the application of biotite mica mineral as a geoindicator that can help the environmental scientists to contribute more effectively to the interdisciplinary efforts in River Science. [ABSTRACT FROM AUTHOR]

This article analyses data on five years of India Rankings to assess its impact on performance parameters of institutions of higher education in terms of publications, citations, patents, highly-cited publications and research funding under broad category of parameter named "Research and Professional Practices". The analysis of data on five years of India Rankings, i.e. 2016 to 2020 on various performance parameters of HEIs provides an interesting insight and reveals that participating institutions are making strenuous effort to improve their performance on various parameters or sub-parameters identified by the NIRF for ranking of HEIs. It is note that the number of publications, citations, and highly-cited publications (HCP) by eligible applicant institutions have increased exponentially over a period of five years from 2016 to 2020. It is interesting to note that per cent of publications, citations, and HCP by the 100 top-ranked institutions has decreased with corresponding increase of publications, citations, and HCP of the remaining institutions. This trend indicates that a good number of remaining institutions have not only intensified their research and publications activities but are also attracting their share of citations. It is also observed that a significant number of NIRF eligible applicants did not have any publication, however, per cent of institutions having "0" publications have decreasing gradually every year from 2017 to 2020. Noticeable and consistent increase in total publications of India, NIRF Eligible Applicants, 100 top-ranked institutions and remaining institutions in Overall category was noticed during past four years, i.e. 2017 to 2020. However, per cent increase in publications of the 100 top-ranked institutions was the highest in overall category. [ABSTRACT FROM AUTHOR]

Introduction: Primary hyperparathyroidism (PHPT), a third common endocrine disorder, varies from asymptomatic disease, mostly seen in the West where routine biochemical screening is practiced, to the classical symptomatic disease mostly seen in the Eastern countries. We aimed to compare the demographic, clinical, biochemical measurements in patients with asymptomatic and symptomatic PHPT from the Indian PHPT registry. Material and methods: Data of PHPT patients from the last 25 years (1995–2019) were analyzed for demographic, clinical presentation and biochemical measurements, and compared these characteristics between asymptomatic and symptomatic PHPT patients. Results: Of the 554 patients, 54 (10%) patients had asymptomatic PHPT. There was a sharp rise in the proportion of asymptomatic PHPT patients of 3% in the first decade to 13% in the second decade of the century (p = 0.003). Patients with asymptomatic PHPT were significantly older (50 vs. 42 years; p < 0.0001) and had higher mean body mass index (27.8 vs. 23.5 kg/m2; p < 0.0001) compared to the symptomatic PHPT group. In addition, asymptomatic PHPT patients had significantly lower median plasma iPTH (180 vs. 370 pg/mL; p < 0.0001), serum alkaline phosphatase (119 vs. 172 IU/L; p < 0.0001), and parathyroid adenoma weight (1.0 vs. 2.62 g; p = 0.006) compared to the symptomatic PHPT group. Conclusion: Although symptomatic PHPT is still most prevalent (> 90%) in India with higher indices of the disease and tumor weights, there is a progressive rise in the prevalence of asymptomatic PHPT patients in the last decade. Improvements in calcium and vitamin D nutrition might account for this change as in the Western series. [ABSTRACT FROM AUTHOR]

This article ranks the same set of Higher Education Institutions (HEIs) in India using four different ranking methodologies, namely, i) NIRF (Overall): used for Overall category of India Rankings; ii) NIRF (Only Research and Professional Practices parameters); iii) Research Ranking Methodology; a new methodology evolved for ranking of research-intensive institutions under NIRF; and vi) IFQ2A index developed by Spanish group of scientists. The four sets of ranked institutions were obtained using methodologies mentioned above and correlation analysis was carried out on these four sets using Pearson Bivariate Correlation. It was found that a very strong and positive correlation exists between ranking of HEIs using new methodology (R2M) evolved for ranking of research-intensive institutions and ranking by HEIs using IFQ2A Index. [ABSTRACT FROM AUTHOR]

The India Rankings 2020 was announced the 5th annual edition of ranking for higher educational institutions in India based on National Institutional Ranking Framework (NIRF). The impact of NIRF among institutions is progressive on their output, outcomes, and outreach to the society. The government of India is also concentrating on several policy decisions in the education sector based on the results of India Rankings. This paper is focused on the study of Research Performance (RP) parameter on India Rankings while expanding five-years window instead of three-years window. Moreover, the study is also focused on Pearson correlation between three-years research performance score and five-years RP score and weighted score of institutions. It is attempted to derive the Spearman rank correlation between RP rank and overall rank based on all parameters score. [ABSTRACT FROM AUTHOR]

This article analyses data on five years of India rankings to assess its impact on performance parameters of institutions of higher education on four (out of five) broad categories of parameters, namely i) Teaching, Learning and Resources; ii) Graduation Outcome; iii) Outreach and Inclusivity; and iv) Perception. The analysis on data on four years of India Rankings, i.e. 2017 to 2020 on various performance parameters of HEIs in engineering discipline provides an interesting insight and reveals that participating institutions are making strenuous effort to improve their performance on various parameters or sub-parameters identified under NIRF. The analyses reflect that performance of remaining eligible institutions has improved on most of the ranking parameters in comparison to the100 topranked institutions over a period of four years of ranking, i.e. from 2017 to 2020. [ABSTRACT FROM AUTHOR]

The aim of the present study was to evaluate the nutritional, anti-nutritional, antioxidant, antimicrobial and prebiotic activity in peels of four selected fruits (apple, sweet lime, papaya and banana) commonly consumed in India. The nutritional and anti-nutritional constituents along with antioxidant activities were determined. Anti-bacterial activity and prebiotic potential of selected fruit peels was also estimated. All the selected fruit peels exhibit good nutritional value along with acceptable level of anti-nutritional factors. The highest values of antioxidant activity, total phenolics and flavonoids were recorded in peels of banana and apple. The results indicate that peels of different fruits can be regarded as natural plant source of antioxidants with high prebiotic potential. [ABSTRACT FROM AUTHOR]

Background: Place of delivery has major implication on decreasing maternal morbidity and mortality. India has adopted various policies to encourage institutional births, still there are large numbers of deliveries which occur at home. Thus, it is imperative to understand the risk factors associated with home deliveries among women in India. Methods: The national representative district level household data-4 (2012-13) have been used for this analysis. A multiple logistic regression model has been used to determine the significant factors associated with home deliveries. Results: A total of 22,363 live births were selected for analysis for the year 2012. Out of which 3,602 (15.4%) are found to be home delivery births, remaining are either private or government institutional births. North-east states are found to be high prevalence of home deliveries. The potential factors viz., age of women, educational level of both husband and wife, age at first birth, higher order parity and not registered for ANC check-up, etc., are significantly associated with home delivery birth preferences among women in India. Conclusion: Our analysis demonstrates that targeting the significant predictors particularly education of family members and compulsory registration for ANC check-up will significantly reduce the preference for home delivery. [ABSTRACT FROM AUTHOR]

Background Axshya SAMVAD is an active tuberculosis (TB) case finding (ACF) strategy under project Axshya (Axshya meaning ‘free of TB’ and SAMVAD meaning ‘conversation’) among marginalized and vulnerable populations in 285 districts of India. Objectives To compare patient characteristics, health seeking, delays in diagnosis and treatment initiation among new sputum smear positive TB patients detected through ACF and passive case finding (PCF) under the national TB programme in marginalized and vulnerable populations between March 2016 and February 2017. Methods This observational analytic study was conducted in 18 randomly sampled Axshya districts. We enrolled all TB patients detected through ACF and an equal number of randomly selected patients detected through PCF in the same settings. Data on patient characteristics, health seeking and delays were collected through record review and patient interviews (at their residence). Delays included patient level delay (from eligibility for sputum examination to first contact with any health care provider (HCP)), health system level diagnosis delay (from contact with first HCP to TB diagnosis) and treatment initiation delays (from diagnosis to treatment initiation). Total delay was the sum of patient level, health system level diagnosis delay and treatment initiation delays. Results We included 234 ACF-diagnosed and 231 PCF-diagnosed patients. When compared to PCF, ACF patients were relatively older (≥65 years, 14% versus 8%, p = 0.041), had no formal education (57% versus 36%, p<0.001), had lower monthly income per capita (median 13.1 versus 15.7 USD, p = 0.014), were more likely from rural areas (92% versus 81%, p<0.002) and residing far away from the sputum microscopy centres (more than 15 km, 24% versus 18%, p = 0.126). Fewer patients had history of significant loss of weight (68% versus 78%, p = 0.011) and sputum grade of 3+ (15% versus 21%, p = 0.060). Compared to PCF, HCP visits among ACF patients was significantly lower (median one versus two HCPs, p<0.001). ACF patients had significantly lower health system level diagnosis delay (median five versus 19 days, p = 0.008) and the association remained significant after adjusting for potential confounders. Patient level and total delays were not significantly different. Conclusion Axshya SAMVAD linked the most impoverished communities to TB care and resulted in reduction of health system level diagnosis delay. [ABSTRACT FROM AUTHOR]

Background: Community-based active case finding (ACF) for tuberculosis (TB) implemented among marginalised and vulnerable populations in 285 districts of India resulted in reduction of diagnosis delay and prevalence of catastrophic costs due to TB diagnosis. We were interested to know whether this translated into improved treatment outcomes. Globally, there is limited published literature from marginalised and vulnerable populations on the independent effect of community-based ACF on treatment outcomes when compared to passive case finding (PCF). Objectives: To determine the relative differences in unfavourable treatment outcomes (death, loss-to-follow-up, failure, not evaluated) of ACF and PCF-diagnosed people. Methods: Cohort study involving record reviews and interviews in 18 randomly selected districts. We enrolled all ACF-diagnosed people with new smear-positive pulmonary TB, registered under the national TB programme between March 2016 and February 2017, and an equal number of randomly selected PCF-diagnosed people in the same settings. We used log binomial models to adjust for confounders. Results: Of 572 enrolled, 275 belonged to the ACF and 297 to the PCF group. The proportion of unfavourable outcomes were 10.2% (95% CI: 7.1%, 14.3%) in the ACF and 12.5% (95% CI: 9.2%, 16.7%) in the PCF group (p = 0.468). The association between ACF and unfavourable outcomes remained non-significant after adjusting for confounders available from records [aRR: 0.83 (95% CI: 0.56, 1.21)]. Due to patient non-availability at their residence, interviews were conducted for 465 (81.3%). In the 465 cohort too, there was no association after adjusting for confounders from records and interviews [aRR: 1.05 (95% CI: 0.62, 1.77)]. Conclusion: We did not find significant differences in the treatment outcomes. Due to the wide CIs, studies with larger sample sizes are urgently required. Studies are required to understand how to translate the benefits of ACF to improved treatment outcomes. [ABSTRACT FROM AUTHOR]

Transitioning to a net-zero world is one of the greatest challenges humanity may face across the world. Nonetheless, land-based carbon removal actions are vital to meet net-zero targets but involve significant trade-offs that may risk food security. The potential increase in demand for land in the near future for land-based climate mitigation methods across India could certainly threaten the right to land and food, especially for people and communities whose livelihoods depend on land. In the context of global efforts to address and combat the climate crisis and to improve food security, agroforestry is a sustainable land use with immense potential to achieve significant impact and synergy across priorities. [ABSTRACT FROM AUTHOR]

The presentation of primary hyperparathyroidism (PHPT) is variable throughout the world. The present study explored retrospective data submitted to the Indian PHPT registry ( http://www.indianphptregistry.com ) between July 2005 and June 2015 from 5 centres covering four different geographical regions. The clinical, biochemical, radiological and histopathological characteristics of PHPT patients across India were analysed for similarity and variability across the centres. A total of 464 subjects (137 men and 327 women) with histopathologically proven PHPT were analysed. The mean age was 41 ± 14 years with a female:male ratio of 2.4:1. The majority (95%) of patients were symptomatic. Common clinical manifestations among all the centres were weakness and fatigability (58.7%), bone pain (56%), renal stone disease (31%), pancreatitis (12.3%) and gallstone disease (11%). Mean serum calcium, parathyroid hormone and inorganic phosphorus levels were 11.9 ± 1.6 mg/dL, 752.4 ± 735.2 pg/mL and 2.8 ± 0.9 mg/dL, respectively. Sestamibi scanning had better sensitivity than ultrasonography in the localisation of parathyroid adenoma; however, when these two modalities were combined, 93% of the cases were correctly localised. Mean parathyroid adenoma weight was 5.6 ± 6.5 g (0.1-54 g). It was concluded that the majority of PHPT patients within India are still mainly symptomatic with >50% of patients presenting with bone disease and one-third with renal impairment. Compared to Western countries, Indian patients with PHPT are younger, biochemical abnormalities are more severe, and adenoma weight is higher. As our observation is largely derived from a tertiary care hospital (no routine screening of serum calcium level), the results do not reflect racial differences in susceptibility to PHPT. [ABSTRACT FROM AUTHOR]

Background: India was estimated to have the largest numbers of stillbirths globally in 2015, and the Indian government has adopted a target of <10 stillbirths per 1,000 births by 2030 through the India Newborn Action Plan (INAP). The objective of this study was to use verbal autopsy interviews to examine factors associated with stillbirth in the Indian state of Bihar and make recommendations for the INAP to better inform the setting of priorities and actions to reduce stillbirths.Methods and Findings: Verbal autopsy interviews were conducted for deaths including stillbirths that occurred from January 2011 to March 2014 in a sample of 109,689 households (87.1% participation) in 1,017 clusters representative of the state of Bihar. The Population Health Metrics Research Consortium shortened verbal autopsy questionnaire was used for each interview, and cause of death was assigned using the SmartVA automated algorithm. A stillbirth was defined as a foetal death with a gestation period of ≥28 weeks wherein the foetus did not show any sign of life. We report on the stillbirth epidemiology and present case studies from the qualitative data on the health provider interface that can be used to improve success of improved, skilled care at birth and delivery interventions. The annualised stillbirth incidence was 21.2 (95% CI 19.7 to 22.6) per 1,000 births, with it being higher in the rural areas. A total of 1,132 stillbirths were identified; 686 (62.2%) were boys, 327 (29.7%) were firstborn, and 760 (68.9%) were delivered at a health facility. Of all the stillbirths, 54.5% were estimated to be antepartum. Only 6,161 (55.9%) of the women reported at least 1 antenatal care visit, and 33% of the women reported not consuming the iron folic acid tablets during pregnancy. Significant differences were seen in delivery-related variables and associated maternal conditions based on the place of delivery and type of stillbirth. Only 6.1% of the women reported having undergone a test to rule out syphilis. For 34.2% of the stillbirths, the possible risk factor for stillbirth was unexplained. For the remaining 65.8% of the women who reported at least 1 complication during the last 3 months of pregnancy, maternal conditions including anaemia, fever during labour, and hypertension accounted for most of the complications. Of importance to note is that the maternal conditions overlapped quite significantly with the other possible underlying risk factors for stillbirth. Obstetrics complications and excessive bleeding during delivery contributed to nearly 30% of the cases as a possible risk factor for stillbirth, highlighting the need for better skilled care during delivery. Of the 5 major themes identified in open narratives, 3 were related to healthcare providers-lack of timely attention, poor skills (knowledge or implementation), and reluctance to deliver a dead baby. The case studies document the circumstances that highlight breakdowns in clinical care around the delivery or missed opportunities that can be used for improving the provision of quality skilled care. The main limitation of these data is that stillbirth is defined based on the gestation period and not based on birth weight; however, this is done in several studies from developing country settings in which birthweight is either not available or accurate.Conclusions: To our knowledge, this study is among the few large, population-based assessments of stillbirths using verbal autopsy at the state level in India. These findings provide detailed insight into investigating the possible risk factors for stillbirths, as well as insight into the ground-level changes that are needed within the health system to design and implement effective preventive and intervention policies to reduce the burden of stillbirths. As most of the stillbirths are preventable with high-quality, evidence-based interventions delivered before and during pregnancy and during labour and childbirth, it is imperative that with INAP in place, India aspires to document stillbirths in a systematic and standardised manner to bridge the knowledge gap for appropriate actions to reduce stillbirths. We have made several recommendations based on our study that could further strengthen the INAP approach to improve the quality and quantity of stillbirth data to avoid this needless loss of lives. [ABSTRACT FROM AUTHOR]

The present study is the first attempt to determine the suitability of groundwater for drinking and irrigation in the Baga-Calangute stretch of Goa. The suitability of groundwater for potable use was assessed by comparing observed values against standards prescribed by the Bureau of Indian Standards, and the quality was classified based on the Weighted Arithmetic Water Quality Index. Most of the groundwater samples (90%) were found to be suitable for drinking except for hardness, chlorides, and nitrates. The percent sodium (%Na), residual sodium carbonate, soluble sodium percentage, sodium adsorption ratio, Kelly's ratio, and Permeability Index were found to be within the prescribed limits for irrigation purposes. The major mechanism controlling groundwater chemistry, i.e., rock-water interaction, was also studied, and it was found that silicate weathering plays a major role in the dissolution of minerals. Based on the hydrochemical characterization, the water was observed to be of the Ca-Na-SO composition type except for one sample which was of the Na-Cl composition type. Classification of the meteoric genesis suggested that the groundwater in surficial aquifers in the region had a deep meteoric percolation, and its chemistry is regulated by rock-water interaction. [ABSTRACT FROM AUTHOR]

• Pollen morphology and ultrastructure of 26 plant taxa of Thymelaeaceae from India is presented, using LM and SEM techniques. • Crotonoid - pattern was noticed. • PCA and HCA suggest four clustering. We provide pollen morphology and ultrastructure of 26 plant taxa, comprising 14 genera, 21 species, 1 sub-species and 3 varieties, of the Thymelaeaceae family from the Indian sub-continent using light micsoscopic (LM) and scanning electron microscopic (SEM) techniques. The principal aim was to provide new and useful information regarding the extent of the pollen morphological diversity among the Thymelaeaceae taxa and, thus, contribute to a better understanding of the taxonomy of the studied taxa. The pollen grains of the studied taxa are essentially radially symmetrical, apolar, (released as) monad, pantoporate with a typical crotonoid pattern, and spheroidal (mostly) in shape; but widespread variations with respect to the number and dispensation of pores, size, exine (ectoexine and endoexine) thickness, and the shape itself (spheroidal, sub-spheroidal and prolate spheroidal), as well as in the amb (outline) have been also recorded. Pollen identification keys, based on the pollen micro-morphological attributes, were also constructed in order to easily identify the 26 studied Thymelaeceae taxa up to species and/or varieties level (high taxonomic resolution, showing taxonomic significance). The pollen morphological attributes of the 26 studied plant taxa of the Thymelaeaceae family were subjected to Principal Component Analysis (PCA) and Hierarchical Component Analysis (HCA), which suggest four clusters. The cophenetic correlation coefficient also validates the four group of clustering. The study will significantly help in the precise pollen identification in fossil (pollen) records for the reconstruction of vegetation dynamics and contemporary climate change during the Quaternary Period in India. Moreover, the present study also helps in determining the phylogenetic and evolutionary trend on the basis of the presence or absence of exine ornamentation and having more or less apertures among the pollen grains of the 26 studied Thymelaeaceae taxa. [ABSTRACT FROM AUTHOR]

Background: Pterygium is an ocular surface disorder with prevalence rates ranges from 0.3% to 29% in different parts of the world. Vascular endothelial growth factor (VEGF) has been detected in increased amounts in pterygium epithelium, compared with normal conjunctiva. Bevacizumab is a recombinant, humanized anti-VEGF antibody suggested as a possible adjunctive therapy for pterygium excision that appears to have a role in prevention of recurrence. We conducted this study to evaluate the role of subconjunctival bevacizumab in primary pterygium surgery in Indian patients.Methods: In this randomized prospective clinical study, the patients were randomized into two groups of 30 patients each. Study group received 1.25 mg/0.05 ml subconjunctival bevacizumab 1 week before pterygium surgery with conjunctival autograft. Control group received 1.25 mg (0.05 ml) subconjunctival normal saline 1 week prior to pterygium surgery with conjunctival autograft. Patients were followed up at day 1, day 7, 1 month and 3 months. The main outcome measures were morphology of pterygium after injection, intra-operative ease, recurrence of pterygia, and any complications.Results: After giving bevacizumab, there was statistically significant improvement in grade, color intensity, size of pterygium, and symptoms of patients. Intra-operatively, less bleeding was observed by the surgeon. No statistically significant difference regarding reduction in astigmatism, improvement of visual acuity, and complications were observed in two groups. Recurrence was noted in five patients (8.33%) in total study population at the end of 3 months. It was present in two patients (6.67%) in Group A and three patients (10%) in Group B.Conclusion: Single preoperative administration of subconjunctival injection bevacizumab given 1 week before the pterygium excision with conjunctival autograft decreases the vascularity of newly formed blood vessels, hence may decrease recurrence rate though not in our study. [ABSTRACT FROM AUTHOR]

Sugarcane bacilliform viruses ( SCBV; genus Badnavirus) cause leaf fleck disease in sugarcane worldwide. SCBV was detected in 28 sugarcane cultivars originating from eight states of India. Eight representative SCBV isolates from five different states showed sequence variability up to 27% in the reverse transcriptase and RNase H ( RT/RNase H) genetic region. Five isolates [SCBV-AP (): , SCBV-Assam (CoBIN94063): , SCBV-Bihar (Bo141): , SCBV-UP (Co1424): and SCBV-UP (CoSe6460): ] showed sequence identity of 86-88% with Sugarcane bacilliform IM virus ( SCBIMV), but the other three isolates [ SCBV-Kerala (Co7219): , SCBV- TN (): and SCBV- UP (CoSe92423): ] showed maximum sequence identity of 75-79% with Sugarcane bacilliform MO virus ( SCBMOV). In phylogenetic analysis, the SCBV isolates segregated into two new subclades and were distinct from the known SCBV genotypes. The rates of non-synonymous and synonymous ( dN/ dS) substitution indicated the signs of purifying selection with strong functional constraints for RT/RNase H region in SCBV population. A variant ( SCBV-UP, CoSe92423) was identified to be a recombinant isolate having two other Indian SCBV isolates as parents. Although RT/RNase H region is a recombination cold spot, a strong recombination might have played a key role in the evolution of this new variant of SCBV. Our study provides an insight into the diverse genetic structure of SCBV population and presence of a novel recombinant SCBV species/variant infecting sugarcane cultivars in India. Our results will be helpful in devising a robust detection procedure for quarantine and field testing of sugarcane germplasm. [ABSTRACT FROM AUTHOR]

Objective This population-based study was conducted to evaluate the performance of colposcopy to assess women with positive visual inspection with acetic acid ( VIA) and/or human papillomavirus ( HPV) tests. Materials and Methods A total of 30 773 women were screened by VIA and oncogenic HPV test. Hybrid capture 2 was used for oncogenic HPV detection. All VIA- and/or HPV-positive women and 8.7% test-negative women had the colposcopy. International Federation of Cervical Pathology & Colposcopy ( IFCPC) 2011 nomenclature was used for colposcopic classification of abnormalities. All women with grade 1 or worse lesions had punch biopsies. Biopsies were also obtained from HPV-positive women with normal colposcopy. Results Colposcopy and satisfactory biopsy reports were available for total 2466 women. The overall strength of agreement between colposcopy and histologic classification of cervical neoplasias was poor (kappa = 0.17). Agreement was better when colposcopy was performed on HPV-positive women compared to VIA-positive women. Sensitivity of colposcopy to detect high-grade squamous intraepithelial lesions ( HSIL) at referral threshold of grade 1 abnormality was 84.8% after correction of verification bias. Colposcopy was most inaccurate in identifying non-neoplastic conditions often encountered in VIA- and/or HPV-positive women. In 68.8% women with normal histology, colposcopic impression was grade 1 and above. Overestimation of disease severity on colposcopy was more common in VIA-positive women. Colposcopy also underestimated severity of disease in 52.6% of women with HSIL diagnosis on biopsy. Conclusions Colposcopy performed well in the overall detection of cervical neoplasias, though its capability for accurate categorisation of degree of abnormality was poor. [ABSTRACT FROM AUTHOR]

Background and Purpose: The purpose of this study was to assess the effectiveness of modified constraint induced movement therapy (m-CIMT) in stroke subjects. Materials and Methods: A total of forty sub-acute stroke subjects were randomly assigned to either a m-CIMT (n = 20) or in a control group (n = 20). The m-CIMT group (14 men, 6 women; mean age = 55.2 years) consisted of structured 2 h therapy sessions emphasizing affected arm use, occurring 5 times/week for 2 weeks. A mitt was used to restrain the unaffected arm for 10 h/day for 2 week. The control group (11 men, 9 women; mean age = 56.4 years) consisted of conventional rehabilitation for time-matched exercise program. The outcome measures were evaluated at pre- and post-intervention by using the Wolf Motor Function Test (WMFT) and Fugl-Meyer assessment (FMA) of motor recovery after stroke. Results: After intervention significant effects were observed in m-CIMT group on WMFT (pre-test and post?test score was 28.04 ± 6.58, 13.59 ± 2.86; P =0.003). Similarly on FMA (pre- and post-test score was 31.15 ± 6.37, 55.7 ± 6.4; P = 0.00). Conclusion: There is a significant improvement in upper extremity function so it indicates that m-CIMT is effective in improving the motor function of the affected arm in stroke subjects. However, its long-term effect has not proved since there was no follow-up after intervention. [ABSTRACT FROM AUTHOR]

Introduction: Re-emergence of chikungunya virus in South India after a gap of 32 years in 2006 affected over a million people in the Indian subcontinent. We kept a close vigil over the emerging trend of this virus between 2006-2010 with a view to establish the identity of the circulating genotype(s) and to determine the route of virus transmission in different parts of India. Methodology: Nucleotide sequencing of the E1 gene region from 36 strains of chikungunya virus from three states in northern India was performed for this present study. Forty-four previously reported E1 sequences, retrieved from the global genome data base were used for making a phylogenetic tree. Results: BLAST search revealed 99% homology of the northern Indian strains of the 2006-2010 outbreak with the Reunion Island isolates of 2006. Northern Indian strains of this study clustered with the East Central South African (ECSA) genotype. Conclusions: Findings indicate that the currently circulating strain of chikungunya virus in northern India had its origin from the 2006 epidemic strain of South India that moved toward northern India via the western central India between 2006-2010 in a phased manner with dominance of the ECSA genotype and not the Asian genotype. [ABSTRACT FROM AUTHOR]

Febuxostat is a novel, potent, non-purine selective xanthine oxidase inhibitor which got approved for marketing in the year late 2009 by Central Drugs Standard Control Organization (CDSCO), India. Systematic search of trials/studies from PubMed and Cochrane database lead to 11 trials which demonstrated its superior ability to lower and maintain serum urate levels below 6 mg/dl compared with conventionally used doses of allopurinol for gout. Almost 45% of studies were of high quality according to Jadad score which proves the studies to be more authentic and reliable. The most common adverse reactions reported were abnormal liver function tests, headache, and gastrointestinal symptoms which were usually mild and transient. However, hepatotoxicity becomes a limitation in the use of febuxostat. Febuxostat seems to be a promising alternative for prescribing in primary care patients who are intolerant to allopurinol or to whom allopurinol is contraindicated but it should be associated with further long term surveillance for its safety and efficacy. [ABSTRACT FROM AUTHOR]

The late Quaternary glacier advances in the Himalayan orogen exhibit a complex interplay of insolation induced changes in summer monsoon and winter westerlies. However, the relative contributions of these moisture sources in driving the glacier advances in the Himalaya are still being debated. Additionally, uncertainties about the timing, and hence the processes, responsible for driving the penultimate Last Glacial Maximum (LGM) in the Central Himalaya, still persist. The present study attempts to address some of these issues by employing detailed moraine stratigraphy supplemented with luminescence dating of three moraine and two relict lake sequences in the Kunti-Banar valley of the Central Himalaya, India. The study revealed that the penultimate glacier advance was significantly more extensive compared to its LGM counterpart. Stratigraphically and chronologically correlated sequences indicate that the penultimate glacial advance corresponded to the cool and dry Marine Isotope Stage 4 (MIS 4) and pluvial early to middle MIS 3. The restricted LGM glacier advance is dated to ∼23 ± 4 ka; while the youngest glacial advance is dated to ∼16.6 ± 0.4 ka and corresponds to the oldest Dryas (OD). Geomorphologically, the oldest Kunti-Banar glacier advance (KBGA)-I moraine was responsible for the obstruction of the meltwater stream leading to the formation of a proglacial lake around 30 ± 3 ka. Similarly, the KBGA-II moraine is overlain by relict lake sediments, with an age range of ∼15 ± 1 ka to present, implying that deglaciation has occurred prior to it. Evidence from the Dhauliganga valley resonates reasonably well with the pattern of glacier advances from Central Himalaya implying the influence of mid-latitude, synoptic-scale climatic perturbations. Particularly, there seems to be a coupling between the enhanced mid-latitude westerlies and phases of glacier advance, whereas the deglaciation phases correspond to the insolation driven enhanced monsoon periods. • Kunti-Banar valley preserves evidence of Central Himalaya's oldest glacier advance. • Three prominent glacier advances extending back to MIS-4 have been identified. • KBGA-I dated between 81 and 41 ka represents the most extensive glacier advance. • KBGA-II dated between 26 and 21 ka broadly corresponds to LGM. • Glacier advances during MLW phases are coupled with Northern Hemisphere cooling. [ABSTRACT FROM AUTHOR]

Recent advancements in spatial modelling and mapping methods have opened up new horizons for monitoring the migration of bird species, which have been altered due to the climate change. The rise of citizen science has also aided the spatiotemporal data collection with associated attributes. The biodiversity data from citizen observatories can be employed in machine learning algorithms for predicting suitable environmental conditions for species' survival and their future migration behaviours. In this study, different environmental variables effective in birds' migrations were analysed, and their habitat suitability was assessed for future understanding of their responses in different climate change scenarios. The Jacobin cuckoo (Clamator jacobinus) was selected as the subject species, since their arrival to India has been traditionally considered as a sign for the start of the Indian monsoon season. For suitability predictions in current and future scenarios, maximum entropy (Maxent) modelling was carried out with environmental variables and species occurrences observed in India and Africa. For modelling, the correlation test was performed on the environmental variables (bioclimatic, precipitation, minimum temperature, maximum temperature, precipitation, wind and elevation). The results showed that precipitation-related variables played a significant role in suitability, and through reclassified habitat suitability maps, it was observed that the suitable areas of India and Africa might decrease in future climatic scenarios (SSPs 2.6, 4.5, 7.0 and 8.5) of 2030 and 2050. In addition, the suitability and unsuitability areas were calculated (in km2) to observe the subtle changes in the ecosystem. Such climate change studies can support biodiversity research and improve the agricultural economy. [ABSTRACT FROM AUTHOR]

Summary: Soil and water are crucial resources for agriculture, especially in arid and semi-arid rain-fed areas, yet farm-level economic impacts and the factors influencing the adoption of measures for their conservation are little studied. The present study used data from 400 farm households to assess factors influencing the adoption of soil and water conservation measures (SWCMs) and their impacts on farm productivity and income in a semi-arid region of central India. We employed a probit model to determine the factors influencing the on-farm adoption of SWCMs and a propensity score matching technique for assessing their impacts. The findings indicate that farmer age and education, off-farm income, farm size and land ownership and access to training are key drivers of the adoption of SWCMs. SWCMs accentuated the input costs by INR 1689–2847 per ha during the rabi cropping season (October–February), but also increased crop productivity and net revenue from farming. The impact in the rabi season was less sensitive to the unobserved confounders than in the kharif season (June–September). Therefore, SWCMs could represent an important strategy for unlocking the cultivation potential of large rain-fed areas and for sustaining the livelihoods of farm households in the ecologically fragile arid and semi-arid tropics. [ABSTRACT FROM AUTHOR]

Sorghum is an important dual-purpose crop of India grown for food and fodder. Prevailing weather conditions during the crop growth period determine the yield of sorghum. Hence, the crop yield forecasting models based on weather parameters will be an appropriate option for policymakers and researchers to develop sustainable cropping strategies. In the present study, six multivariate weather-based models viz., least absolute shrinkage and selection operator (LASSO), elastic net (ENET), principal component analysis (PCA) in combination with stepwise multiple linear regression (SMLR), artificial neural network (ANN) alone and in combination with PCA and ridge regression model are examined by fixing 90% of the data for calibration and remaining dataset for validation to forecast rabi sorghum yield for different districts of Karnataka. The R2 and root mean square error (RMSE) during calibration ranged between 0.42 to 0.98 and 30.48 to 304.17 kg ha−1, respectively, without actual evapotranspiration (AET) whereas, these evaluation parameters varied from 0.38 to 0.99 and 19.84 to 308.79 kg ha−1, respectively with AET inclusion. During validation, the RMSE and nRMSE (normalized root mean square error) varied between 88.99 to 1265.03 kg ha−1 and 4.49 to 96.84%, respectively without AET and including AET as one of the weather variable RMSE and nRMSE were 63.48 to 1172.01 kg ha−1 and 4.16 to 92.56%, respectively. The performance of six multivariate models revealed that LASSO was the best model followed by ENET compared to PCA_SMLR, ANN, PCA_ANN and ridge regression models because of reduced overfitting through penalisation of regression coefficient. Thus, it can be concluded that LASSO and ENET weather-based models can be effectively utilized for the district level forecast of sorghum yield. [ABSTRACT FROM AUTHOR]

The author offers a commentary on military training camps in Pakistan-occupied Kashmir (PoK). He says that PoK became a safe haven for those linked with international terror outfits like Al Qaeda. He believes that the proliferation of militant camps in PoK could also be due to the lack of socio-economic development. He mentions poverty, unemployment and an acute sense of alienation among the people as problems in PoK.

Clean energy transition via utilizing biomass resources has been projected as an important climate change mitigation strategy. A vital characteristic of biomass is its localized nature; therefore, bioenergy utilization should follow decentralized planning. Agrarian countries like India can take benefit of its large agricultural biomass waste pool to produce clean renewable energy. However, prior knowledge of spatio-temporal distribution, competing uses, and biomass characteristics are necessary for successful bioenergy planning. This paper assesses biomass resource and its power generation potential at different agro-climatic zone levels in the state of Rajasthan, India considering crop residue biomass (25 different crop residues from 14 crops) and livestock manure (from cattle, buffalo, and poultry). Uncertainties associated with the availability of biomass and the power generation potential are assessed for each agro-climatic zone under different scenarios. Greenhouse gases (GHGs) emissions from biomass-based power generations are also estimated and compared with biomass-equivalent coal power plants. It is observed that the annual biomass power potential of Rajasthan is 3056 MW (2496 MW from crop residues and 560 MW from livestock manure). Scenario analysis suggests that the potential varies from 2445 to 6045 MW under different biomass availability and power plant operating conditions. Annual GHGs emissions due to biomass power generation is 5053 kt CO 2 eq. Replacing coal-based power with biomass power would result in annual GHGs savings of 11412 kt CO 2 eq. The paper also discusses various carriers and barriers viz. logistics, institutional, financial and technical in setting up decentralized bioenergy plants. Outcomes of the present study are expected to assist renewable energy planners in India. • Biomass resources and their power potential are assessed for Rajasthan, India. •Biomass power potential for different selected scenario ranges from 2445-6045 MW. •GHG emissions from biomass power is assessed and compared with fossil fuels. •Spatio-temporal variability, low density and logistics are limitations of biomass. •Favourable policies, technologies and market can help to promote bioenergy sector. [ABSTRACT FROM AUTHOR]

Contamination of raw materials of herbal drugs by microorganisms is one of the major reasons for decline of India's share in the global herbal market. The qualitative and quantitative effects of microbial and mycotoxin contamination of raw materials of herbal drugs as well as possible strategies for their safe preservation have been discussed here. [ABSTRACT FROM AUTHOR]