5 results on '"Singh, Rajan"'
Search Results
2. Prevalence and risk factors of gastroesophageal reflux disease in a rural Indian population.
- Author
-
Ghoshal UC, Singh R, and Rai S
- Subjects
- Adolescent, Adult, Aged, Body Mass Index, Carbonated Beverages adverse effects, Carbonated Beverages statistics & numerical data, Cross-Sectional Studies, Diet adverse effects, Diet statistics & numerical data, Dyspepsia epidemiology, Female, Gastroesophageal Reflux etiology, Health Surveys, Heartburn epidemiology, Humans, India epidemiology, Male, Middle Aged, Odds Ratio, Oryza adverse effects, Prevalence, Prospective Studies, Risk Factors, Socioeconomic Factors, Surveys and Questionnaires, Tobacco Use adverse effects, Tobacco Use epidemiology, Young Adult, Gastroesophageal Reflux epidemiology, Rural Population statistics & numerical data
- Abstract
Background: Studies on frequency and risk factors of gastroesophageal reflux disease (GERD) in the rural Indian population are scanty., Methods: This household survey was undertaken by the trained interviewers in the adult population (≥ 18 years) in four villages in northern India using translated-validated Enhanced Asian Rome III and hospital anxiety and depression questionnaires., Results: Of 2774 subjects, 2019 (72.8%) had no heartburn. Heartburn frequency was as follows: 314 (11.3%) once/week, 143 (5.2%) twice/week, 85 (3.1%) thrice/week, 69 (2.5%) four times/week, 48 (1.7%) five times/week, 18 (0.6%) six times/week, 41 (1.5%) daily, 37 (1.4%) > once daily. A total of 298 (10.7%) had GERD (definition: heartburn > twice/week). Older age (36.5 vs. 35 years), non-Hindu religion (7, 2.4% vs. 30, 1.2%), lower education (127, 42.6% vs. 789, 31.9%), lower socioeconomic class (94, 31.5% vs. 517, 20.9%) and income (below Indian National Rupees [INR] 458; 105, 35.2% vs. 599, 24.2%), non-vegetarian diet (15, 5% vs. 105, 4.2%), intake of tea/coffee (260, 87.2% vs. 1687, 68.1%), carbonated soft drinks (216, 72.5% vs. 1234, 49.8%), and alcohol (48, 16.1% vs. 313, 12.6%), tobacco chewing (116, 38.9% vs. 681, 27.5%), and smoking (105, 35.2% vs. 672, 27.1%) were associated with GERD on univariate analysis. On multivariate analysis, body mass index > 25 kg/m
2 (odds ratio [OR] 1.23; 95% CI 0.88-1.71), predominant rice eating (1.13; 0.74-1.74), tobacco chewing and smoking (1.68; 1.24-2.30 and 1.36; 0.99-1.88), and alcohol (1.2; 0.78-1.83) and carbonated soft drinks (2.48; 1.79-3.44) intake were associated with GERD. A total of 122 (41%) had associated functional dyspepsia. Psychological comorbidities were commoner among those with than without GERD., Conclusion: In this rural Indian population, 10.7% had GERD and predominant rice eating, tobacco chewing, and carbonated soft drink intake were the risk factors. Psychological comorbidities were common.- Published
- 2021
- Full Text
- View/download PDF
3. Multi-analytic approach elucidates significant role of hormonal and hepatocanalicular transporter genetic variants in gallstone disease in North Indian population.
- Author
-
Srivastava A, Mishra A, Singh R, Rai R, Srivastava N, and Mittal B
- Subjects
- Adipogenesis genetics, Case-Control Studies, Decision Trees, Female, Gallstones metabolism, Gallstones pathology, Genetic Predisposition to Disease genetics, Haplotypes genetics, Humans, India, Linkage Disequilibrium genetics, Male, Middle Aged, Computational Biology methods, Gallstones genetics, Hormones genetics, Membrane Transport Proteins genetics, Polymorphism, Single Nucleotide, White People genetics
- Abstract
Objective: Cholesterol gallstone disease (CGD) is a multifactorial and multistep disease. Apart from female gender and increasing age being the documented non-modifiable risk factor for gallstones the pathobiological mechanisms underlying the phenotypic expression of CGD appear to be rather complex, and one or more variations in genes could play critical roles in the diverse pathways further progressing to cholesterol crystal formation. In the present study we performed genotyping score, Multifactor dimensionality reduction (MDR) and Classification and Regression Tree analysis (CART) to identify combinations of alleles among the hormonal, hepatocanalicular transporter and adipogenesis differentiation pathway genes in modifying the risk for CGD., Design: The present case-control study recruited total of 450 subjects, including 230 CGD patients and 220 controls. We analyzed common ESR1, ESR2, PGR, ADRB3, ADRA2A, ABCG8, SLCO1B1, PPARγ2, and SREBP2 gene polymorphisms to find out combinations of genetic variants contributing to CGD risk, using multi-analytical approaches (G-score, MDR, and CART)., Results: Single locus analysis by logistic regression showed association of ESR1 IVS1-397C>T (rs2234693), IVS1-351A>G (rs9340799) PGR ins/del (rs1042838) ADRB3-190 T>C (rs4994) ABCG8 D19H (rs11887534), SLCO1B1 Exon4 C>A (rs11045819) and SREBP2 1784G>C (rs2228314) with CGD risk. However, the MDR and CART analysis revealed ESR1 IVS1-397C>T (rs2234693) ADRB3-190 T>C (rs4994) and ABCG8 D19H (rs11887534) polymorphisms as the best polymorphic signature for discriminating between cases and controls. The overall odds ratio for the applied multi-analytical approaches ranged from 4.33 to 10.05 showing an incremental risk for cholesterol crystal formation. In conclusion, our muti-analytical approach suggests that, ESR1, ADRB3, in addition to ABCG8 genetic variants confer significant risk for cholesterol gallstone disease.
- Published
- 2013
- Full Text
- View/download PDF
4. Lactase persistence/non-persistence genetic variants in irritable bowel syndrome in an endemic area for lactose malabsorption.
- Author
-
Kumar S, Ranjan P, Mittal B, Singh R, and Ghoshal UC
- Subjects
- Adult, Female, Gene Frequency, Genotype, Humans, India epidemiology, Intestine, Small enzymology, Irritable Bowel Syndrome physiopathology, Lactose Intolerance epidemiology, Male, Middle Aged, Sample Size, Irritable Bowel Syndrome enzymology, Irritable Bowel Syndrome genetics, Lactase genetics, Lactose Intolerance genetics, Polymorphism, Genetic
- Abstract
Background and Aim: Lactase non-persistence is common in India. We evaluated: (i) frequency of lactase gene (C/T-13910 and G/A-22018) polymorphisms in irritable bowel syndrome (IBS) and healthy controls (HC), (ii) association between these polymorphisms and IBS-subtypes and symptoms., Methods: A total of 150 IBS patients (Rome-III criteria) and 252 age and gender-matched HC were evaluated for C/T-13910 and G/A-22018 genotypes using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)., Results: Totals of 79 (52%), 52 (35%) and 19 (13%) patients had diarrhea-predominant IBS (D-IBS), constipation predominant IBS (C-IBS) and alternating diarrhea and constipation IBS (A-IBS), respectively (Rome-III). Frequency of C/T-13910 [genotypes: CC 102 (68%), CT 43 (29%), TT 5 (3%) vs CC 155 (61%), CT 83 (33%), TT 14 (6%), P > 0.05] and G/A-22018 [GG 97 (65%), GA 41 (27%), AA 12 (8%) vs GG 154 (61%), GA 78 (31%), AA 20 (8%), P > 0.05] were similar among IBS and HC. Patients with D-IBS more often had C/T-13910 and G/A-22018 genotypes than C-IBS (CC 71 [90%], CT 6 [8%], TT 2 [2%]) versus (24 [46%], 25 [48%], 3 [6%]), A-IBS (7 [39%], 12 [63%], 0, [0%]) and HC (155 [61%], 83 [33%], 14 [6%]), P < 0.0001 and (GG 69 [87%], GA 6 [8%], AA 4 [5%]) vs (22 [42%], 24 [46%], 6 [12%]) vs (6 [32%], 11 [58%], 2 [10%]), P < 0.0001. IBS with CC and GG genotypes more often had abdominal pain (P = 0.005), distension (P = 0.031) and higher stool frequency (P = 0.003) and reported symptoms following dairy products than non-CC (P < 0.0001)., Conclusion: Though C/T-13910 and G/A-22018 polymorphisms were comparable among IBS and HC, these were more common among D-IBS and reported some symptoms like abdominal pain, bloating and exacerbation by dairy products., (© 2012 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.)
- Published
- 2012
- Full Text
- View/download PDF
5. Functional dyspepsia: the Indian scenario.
- Author
-
Ghoshal UC and Singh R
- Subjects
- Anti-Bacterial Agents therapeutic use, Asian People, Dyspepsia diagnosis, Dyspepsia epidemiology, Helicobacter Infections complications, Helicobacter Infections ethnology, Humans, India epidemiology, Prevalence, Treatment Outcome, Dyspepsia etiology, Dyspepsia physiopathology, Gastric Acid metabolism, Helicobacter Infections microbiology, Helicobacter pylori pathogenicity
- Published
- 2012
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.