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1. Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.

Author

Neogi U, Rao SD, Bontell I, Verheyen J, Rao VR, Gore SC, Soni N, Shet A, Schülter E, Ekstrand ML, Wondwossen A, Kaiser R, Madhusudhan MS, Prasad VR, and Sonnerborg A

Subjects
Adult, Cohort Studies, Female, Genotype, HIV-1 classification, HIV-1 isolation & purification, Humans, India, Male, Middle Aged, Treatment Failure, Drug Resistance, Viral, HIV Infections drug therapy, HIV Infections virology, HIV Protease Inhibitors therapeutic use, HIV-1 genetics, Mutagenesis, Insertional, gag Gene Products, Human Immunodeficiency Virus genetics
Abstract

A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratio=17.1, P < 0.001) but was naturally present in half of untreated Ethiopian HIV-1C sequences. The insertion is predicted to restore ALIX-mediated virus release pathway, which is lacking in HIV-1C. The clinical importance of the insertion needs to be evaluated in HIV-1C dominating regions wherein the use of protease inhibitor drugs are being scaled up.

Published
2014
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