1. HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 271 Southeast Asia Indians from Peninsular Malaysia.
- Author
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Nurul-Aain AF, Tan LK, Heselynn H, Nor-Shuhaila S, Eashwary M, Wahinuddin S, Lau IS, Gun SC, Mohd-Shahrir MS, Ainon MM, Azmillah R, Muhaini O, Shahnaz M, and Too CL
- Subjects
- Alleles, Asia, Southeastern, Asian People, Gene Frequency, Genetics, Population, Haplotypes, Humans, India ethnology, Malaysia epidemiology, Malaysia ethnology, Ethnicity, Genotype, HLA-A Antigens genetics, HLA-B Antigens genetics, HLA-C Antigens genetics, HLA-DQ beta-Chains genetics, HLA-DRB1 Chains genetics
- Abstract
A total of 271 Southeast Asia Indians from Peninsular Malaysia were genotyped for HLA-A, -B, -C, -DRB1, and -DQB1 loci using polymerase chain reaction sequence-specific oligonucleotide probe hybridization methods. In this report, HLA-B and HLA-DQB1 was in Hardy-Weinberg proportions (HWEP) (p > 0.05). We observed significant deviation from the HWEP for HLA-A (p < 0.05), HLA-C (p < 0.01) and HLA-DRB1 (p < 0.01) loci. This genotype data is available in Allele Frequencies Network Database (AFND) Dos Santos et al. (2016)., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.)
- Published
- 2020
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