1. A Prospective Observational Case-Control Study of Serum HE4 as a Diagnostic Marker of Female Breast Malignancy in a Tertiary Care Center in North India.
- Author
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Srivastava, Vaibhav, Singh, Rahul, and Dahiya, Mukul
- Subjects
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BREAST tumor diagnosis , *PROTEINS , *RECEIVER operating characteristic curves , *BREAST tumors , *SCIENTIFIC observation , *GENETIC markers , *ENZYME-linked immunosorbent assay , *TUMOR markers , *TERTIARY care , *DESCRIPTIVE statistics , *LONGITUDINAL method , *GENE expression , *CASE-control method , *TUMOR antigens , *SENSITIVITY & specificity (Statistics) , *SYMPTOMS - Abstract
Human epididymis protein 4 (HE4) is a secretory protein encoded by the WFDC2 gene. The potential use of HE4 as a tumor marker has been supported by an increasing number of studies demonstrating an upregulation of HE4 in a range of malignant neoplasm. The aim of the study was to examine the association between the serum levels of HE4 and the clinico-pathological variables and to assess the potential use of circulatory HE4 for the diagnosis of breast cancer. An observational case-control study was carried out in P.G. Department of General Surgery, MLN Medical College, Prayagraj. Forty patients with breast cancer were taken as cases, and thirty healthy individuals were taken as controls. HE4 and CA125 were measured using ELISA test. There was a statistically significant strong positive correlation between CA125 and serum HE4 (rho = 0.7, p < 0.001) with sensitivity for predicting case of 93.33% and a specificity of 80.00% with AUROC of 0.8483. Serum HE4 does not change with progression of stages of malignancy. Serum HE4 had good diagnostic performance, and it can be used as a diagnostic marker of breast malignancy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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